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Association of sickle cell trait with β-cell dysfunction and physical activity in adults living with and without HIV in Tanzania

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Author

Kweka, Belinda V ; Fredrick, Cyprian ; Kitilya, Brenda ; Jeremiah, Kidola ; Lyimo, Eric ; Filteau, Suzanne ; Rehman, Andrea M ; Friis, Henrik ; Olsen, Mette F ; Faurholt-Jepsen, Daniel ; Krogh-Madsen, Rikke ; PrayGod, George. / Association of sickle cell trait with β-cell dysfunction and physical activity in adults living with and without HIV in Tanzania. I: APMIS - Journal of Pathology, Microbiology and Immunology. 2022 ; Bind 130, Nr. 4. s. 230-239.

Bibtex

@article{076f1338ab9b47288352e620511fdf5a,
title = "Association of sickle cell trait with β-cell dysfunction and physical activity in adults living with and without HIV in Tanzania",
abstract = "This study aimed to investigate sickle cell trait (SCT) associations with physical activity, markers of insulin secretion and resistance, and glucose among people living with HIV infection (PLWH), both antiretroviral therapy (ART) naive and experienced, and HIV-uninfected adults. This was a cross-sectional study conducted in Mwanza, Northwestern Tanzania. We used data of 668 participants attained from two sub-studies of CICADA study. Mean age was 40 (SD 11.5) years, 402 (61.7%) were females and 157 (24.1%) had SCT. PLWH were 422 (64.7%), of these, 80 (18.9%) were on ART. People with SCT had higher risk of having an isolated β-cell dysfunction compared to those without SCT (RRR = 1.82, CI: 1.10, 3.01, p = 0.02). People with SCT but without HIV infection had lower average acceleration on the trunk longitudinal axis (ACCx) and higher level of self-reported physical activity. 30 min oral glucose tolerance test among PLWH on ART was higher in those with SCT compared to those without SCT. People with SCT are at higher risk of having β-cell dysfunction and those with SCT on ART are at more risk of developing diabetes. Future studies to investigate the interaction between SCT and HIV/ART on risk of diabetes should be considered.",
keywords = "antiretroviral therapy, HIV, Sickle cell trait, β-cell dysfunction and physical activity",
author = "Kweka, {Belinda V} and Cyprian Fredrick and Brenda Kitilya and Kidola Jeremiah and Eric Lyimo and Suzanne Filteau and Rehman, {Andrea M} and Henrik Friis and Olsen, {Mette F} and Daniel Faurholt-Jepsen and Rikke Krogh-Madsen and George PrayGod",
note = "This article is protected by copyright. All rights reserved.",
year = "2022",
month = apr,
doi = "10.1111/apm.13214",
language = "English",
volume = "130",
pages = "230--239",
journal = "APMIS - Journal of Pathology, Microbiology and Immunology",
issn = "0903-4641",
publisher = "Wiley Online",
number = "4",

}

RIS

TY - JOUR

T1 - Association of sickle cell trait with β-cell dysfunction and physical activity in adults living with and without HIV in Tanzania

AU - Kweka, Belinda V

AU - Fredrick, Cyprian

AU - Kitilya, Brenda

AU - Jeremiah, Kidola

AU - Lyimo, Eric

AU - Filteau, Suzanne

AU - Rehman, Andrea M

AU - Friis, Henrik

AU - Olsen, Mette F

AU - Faurholt-Jepsen, Daniel

AU - Krogh-Madsen, Rikke

AU - PrayGod, George

N1 - This article is protected by copyright. All rights reserved.

PY - 2022/4

Y1 - 2022/4

N2 - This study aimed to investigate sickle cell trait (SCT) associations with physical activity, markers of insulin secretion and resistance, and glucose among people living with HIV infection (PLWH), both antiretroviral therapy (ART) naive and experienced, and HIV-uninfected adults. This was a cross-sectional study conducted in Mwanza, Northwestern Tanzania. We used data of 668 participants attained from two sub-studies of CICADA study. Mean age was 40 (SD 11.5) years, 402 (61.7%) were females and 157 (24.1%) had SCT. PLWH were 422 (64.7%), of these, 80 (18.9%) were on ART. People with SCT had higher risk of having an isolated β-cell dysfunction compared to those without SCT (RRR = 1.82, CI: 1.10, 3.01, p = 0.02). People with SCT but without HIV infection had lower average acceleration on the trunk longitudinal axis (ACCx) and higher level of self-reported physical activity. 30 min oral glucose tolerance test among PLWH on ART was higher in those with SCT compared to those without SCT. People with SCT are at higher risk of having β-cell dysfunction and those with SCT on ART are at more risk of developing diabetes. Future studies to investigate the interaction between SCT and HIV/ART on risk of diabetes should be considered.

AB - This study aimed to investigate sickle cell trait (SCT) associations with physical activity, markers of insulin secretion and resistance, and glucose among people living with HIV infection (PLWH), both antiretroviral therapy (ART) naive and experienced, and HIV-uninfected adults. This was a cross-sectional study conducted in Mwanza, Northwestern Tanzania. We used data of 668 participants attained from two sub-studies of CICADA study. Mean age was 40 (SD 11.5) years, 402 (61.7%) were females and 157 (24.1%) had SCT. PLWH were 422 (64.7%), of these, 80 (18.9%) were on ART. People with SCT had higher risk of having an isolated β-cell dysfunction compared to those without SCT (RRR = 1.82, CI: 1.10, 3.01, p = 0.02). People with SCT but without HIV infection had lower average acceleration on the trunk longitudinal axis (ACCx) and higher level of self-reported physical activity. 30 min oral glucose tolerance test among PLWH on ART was higher in those with SCT compared to those without SCT. People with SCT are at higher risk of having β-cell dysfunction and those with SCT on ART are at more risk of developing diabetes. Future studies to investigate the interaction between SCT and HIV/ART on risk of diabetes should be considered.

KW - antiretroviral therapy

KW - HIV

KW - Sickle cell trait

KW - β-cell dysfunction and physical activity

UR - http://www.scopus.com/inward/record.url?scp=85125473622&partnerID=8YFLogxK

U2 - 10.1111/apm.13214

DO - 10.1111/apm.13214

M3 - Journal article

C2 - 35167170

VL - 130

SP - 230

EP - 239

JO - APMIS - Journal of Pathology, Microbiology and Immunology

JF - APMIS - Journal of Pathology, Microbiology and Immunology

SN - 0903-4641

IS - 4

M1 - 13214

ER -

ID: 74471507