Association of serum TSH with anthropometric markers of obesity in the general population

Daniel Tiller; Till Ittermann; Karin Halina Greiser; Christa Meisinger; Agger Carsten; Albert Hofman; Betina Heinsbæk Thuesen; Allan Linneberg; Robin Peeters; Oscar Franco; Margit Heier; Alexander Kluttig; Karl Werdan; Bruno Stricker; Sabine Schipf; Marcello Ricardo Paulista Markus; Marcus Dörr; Henry Völzke; Johannes Haerting

doi:10.1089/thy.2015.0410

Association of serum TSH with anthropometric markers of obesity in the general population

Daniel Tiller, Till Ittermann, Karin Halina Greiser, Christa Meisinger, Agger Carsten, Albert Hofman, Betina Heinsbæk Thuesen, Allan Linneberg, Robin Peeters, Oscar Franco, Margit Heier, Alexander Kluttig, Karl Werdan, Bruno Stricker, Sabine Schipf, Marcello Ricardo Paulista Markus, Marcus Dörr, Henry Völzke, Johannes Haerting

Klinisk Eksperimentel Forskningsafdeling, Glostrup

32 Citationer (Scopus)

Abstract

CONTEXT: Except from associations study with body weight, there are few longitudinal data regarding the association between thyroid function and anthropometric such as waist circumference, waist-to-hip-ratio or waist-to height-ratio.

OBJECTIVE: We aimed at investigating the association of thyroid stimulating hormone (TSH) at baseline with changes in different anthropometric markers between baseline and follow-up in the general population.

DESIGN AND SETTING: We used data from four population-based longitudinal cohort studies and one population-based cross-sectional study.

SUBJECTS: We studied 16,902 (8,204 males and 8,698 females) subjects aged 20 to 95 years from the general population.

MAIN OUTCOME MEASURES: We measured body mass index, waist-circumference, waist-to-hip- ratio and waist-to-height-ratio. Multivariable median regression models were calculated adjusting for the following covariates: age, sex, baseline value of the respective anthropometric marker, smoking status, follow-up-time period and study site.

RESULTS: In cross-sectional analyses, serum TSH within the reference range was positively associated with waist circumference (β 0.94 cm (95%CL 0.56; 1.32)) and waist-to-height-ratio (β 0.029 (95%CL 0.017; 0.042)). These associations were also present for the full range of TSH. In the longitudinal analyses, serum TSH at baseline was inversely associated with 5-year change of all considered anthropometric measures within the prior defined study-specific reference range, as well as in the full range of serum TSH.

CONCLUSION: High TSH serum levels were positively associated with current anthropometric markers even in the study-specific reference ranges. In contrast, high TSH serum levels were associated with decreased anthropometric markers over a time span of approximately 5 years. Further research is needed to determine possible clinical implications as well as public health consequences of these findings.

Originalsprog	Engelsk
Tidsskrift	Thyroid : official journal of the American Thyroid Association
Vol/bind	26
Sider (fra-til)	1205-14
ISSN	1050-7256
DOI	https://doi.org/10.1089/thy.2015.0410
Status	Udgivet - 8 jul. 2016

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10.1089/thy.2015.0410

Citationsformater

Tiller, D., Ittermann, T., Greiser, K. H., Meisinger, C., Carsten, A., Hofman, A., Thuesen, B. H., Linneberg, A., Peeters, R., Franco, O., Heier, M., Kluttig, A., Werdan, K., Stricker, B., Schipf, S., Markus, M. R. P., Dörr, M., Völzke, H., & Haerting, J. (2016). Association of serum TSH with anthropometric markers of obesity in the general population. Thyroid : official journal of the American Thyroid Association, 26, 1205-14. https://doi.org/10.1089/thy.2015.0410

Tiller, D, Ittermann, T, Greiser, KH, Meisinger, C, Carsten, A, Hofman, A, Thuesen, BH, Linneberg, A, Peeters, R, Franco, O, Heier, M, Kluttig, A, Werdan, K, Stricker, B, Schipf, S, Markus, MRP, Dörr, M, Völzke, H & Haerting, J 2016, 'Association of serum TSH with anthropometric markers of obesity in the general population', Thyroid : official journal of the American Thyroid Association, bind 26, s. 1205-14. https://doi.org/10.1089/thy.2015.0410

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title = "Association of serum TSH with anthropometric markers of obesity in the general population",

abstract = "CONTEXT: Except from associations study with body weight, there are few longitudinal data regarding the association between thyroid function and anthropometric such as waist circumference, waist-to-hip-ratio or waist-to height-ratio.OBJECTIVE: We aimed at investigating the association of thyroid stimulating hormone (TSH) at baseline with changes in different anthropometric markers between baseline and follow-up in the general population.DESIGN AND SETTING: We used data from four population-based longitudinal cohort studies and one population-based cross-sectional study.SUBJECTS: We studied 16,902 (8,204 males and 8,698 females) subjects aged 20 to 95 years from the general population.MAIN OUTCOME MEASURES: We measured body mass index, waist-circumference, waist-to-hip- ratio and waist-to-height-ratio. Multivariable median regression models were calculated adjusting for the following covariates: age, sex, baseline value of the respective anthropometric marker, smoking status, follow-up-time period and study site.RESULTS: In cross-sectional analyses, serum TSH within the reference range was positively associated with waist circumference (β 0.94 cm (95%CL 0.56; 1.32)) and waist-to-height-ratio (β 0.029 (95%CL 0.017; 0.042)). These associations were also present for the full range of TSH. In the longitudinal analyses, serum TSH at baseline was inversely associated with 5-year change of all considered anthropometric measures within the prior defined study-specific reference range, as well as in the full range of serum TSH.CONCLUSION: High TSH serum levels were positively associated with current anthropometric markers even in the study-specific reference ranges. In contrast, high TSH serum levels were associated with decreased anthropometric markers over a time span of approximately 5 years. Further research is needed to determine possible clinical implications as well as public health consequences of these findings.",

author = "Daniel Tiller and Till Ittermann and Greiser, {Karin Halina} and Christa Meisinger and Agger Carsten and Albert Hofman and Thuesen, {Betina Heinsb{\ae}k} and Allan Linneberg and Robin Peeters and Oscar Franco and Margit Heier and Alexander Kluttig and Karl Werdan and Bruno Stricker and Sabine Schipf and Markus, {Marcello Ricardo Paulista} and Marcus D{\"o}rr and Henry V{\"o}lzke and Johannes Haerting",

year = "2016",

month = jul,

day = "8",

doi = "10.1089/thy.2015.0410",

language = "English",

volume = "26",

pages = "1205--14",

journal = "Thyroid : official journal of the American Thyroid Association",

issn = "1050-7256",

publisher = "Mary Ann Liebert Inc.",

}

TY - JOUR

T1 - Association of serum TSH with anthropometric markers of obesity in the general population

AU - Tiller, Daniel

AU - Ittermann, Till

AU - Greiser, Karin Halina

AU - Meisinger, Christa

AU - Carsten, Agger

AU - Hofman, Albert

AU - Thuesen, Betina Heinsbæk

AU - Linneberg, Allan

AU - Peeters, Robin

AU - Franco, Oscar

AU - Heier, Margit

AU - Kluttig, Alexander

AU - Werdan, Karl

AU - Stricker, Bruno

AU - Schipf, Sabine

AU - Markus, Marcello Ricardo Paulista

AU - Dörr, Marcus

AU - Völzke, Henry

AU - Haerting, Johannes

PY - 2016/7/8

Y1 - 2016/7/8

N2 - CONTEXT: Except from associations study with body weight, there are few longitudinal data regarding the association between thyroid function and anthropometric such as waist circumference, waist-to-hip-ratio or waist-to height-ratio.OBJECTIVE: We aimed at investigating the association of thyroid stimulating hormone (TSH) at baseline with changes in different anthropometric markers between baseline and follow-up in the general population.DESIGN AND SETTING: We used data from four population-based longitudinal cohort studies and one population-based cross-sectional study.SUBJECTS: We studied 16,902 (8,204 males and 8,698 females) subjects aged 20 to 95 years from the general population.MAIN OUTCOME MEASURES: We measured body mass index, waist-circumference, waist-to-hip- ratio and waist-to-height-ratio. Multivariable median regression models were calculated adjusting for the following covariates: age, sex, baseline value of the respective anthropometric marker, smoking status, follow-up-time period and study site.RESULTS: In cross-sectional analyses, serum TSH within the reference range was positively associated with waist circumference (β 0.94 cm (95%CL 0.56; 1.32)) and waist-to-height-ratio (β 0.029 (95%CL 0.017; 0.042)). These associations were also present for the full range of TSH. In the longitudinal analyses, serum TSH at baseline was inversely associated with 5-year change of all considered anthropometric measures within the prior defined study-specific reference range, as well as in the full range of serum TSH.CONCLUSION: High TSH serum levels were positively associated with current anthropometric markers even in the study-specific reference ranges. In contrast, high TSH serum levels were associated with decreased anthropometric markers over a time span of approximately 5 years. Further research is needed to determine possible clinical implications as well as public health consequences of these findings.

AB - CONTEXT: Except from associations study with body weight, there are few longitudinal data regarding the association between thyroid function and anthropometric such as waist circumference, waist-to-hip-ratio or waist-to height-ratio.OBJECTIVE: We aimed at investigating the association of thyroid stimulating hormone (TSH) at baseline with changes in different anthropometric markers between baseline and follow-up in the general population.DESIGN AND SETTING: We used data from four population-based longitudinal cohort studies and one population-based cross-sectional study.SUBJECTS: We studied 16,902 (8,204 males and 8,698 females) subjects aged 20 to 95 years from the general population.MAIN OUTCOME MEASURES: We measured body mass index, waist-circumference, waist-to-hip- ratio and waist-to-height-ratio. Multivariable median regression models were calculated adjusting for the following covariates: age, sex, baseline value of the respective anthropometric marker, smoking status, follow-up-time period and study site.RESULTS: In cross-sectional analyses, serum TSH within the reference range was positively associated with waist circumference (β 0.94 cm (95%CL 0.56; 1.32)) and waist-to-height-ratio (β 0.029 (95%CL 0.017; 0.042)). These associations were also present for the full range of TSH. In the longitudinal analyses, serum TSH at baseline was inversely associated with 5-year change of all considered anthropometric measures within the prior defined study-specific reference range, as well as in the full range of serum TSH.CONCLUSION: High TSH serum levels were positively associated with current anthropometric markers even in the study-specific reference ranges. In contrast, high TSH serum levels were associated with decreased anthropometric markers over a time span of approximately 5 years. Further research is needed to determine possible clinical implications as well as public health consequences of these findings.

U2 - 10.1089/thy.2015.0410

DO - 10.1089/thy.2015.0410

M3 - Journal article

C2 - 27393002

SN - 1050-7256

VL - 26

SP - 1205

EP - 1214

JO - Thyroid : official journal of the American Thyroid Association

JF - Thyroid : official journal of the American Thyroid Association

ER -

Association of serum TSH with anthropometric markers of obesity in the general population

Abstract

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