TY - JOUR
T1 - Association of Psychobehavioral Variables With HOMA-IR and BMI Differs for Men and Women With Prediabetes in the PREVIEW Lifestyle Intervention
AU - Adam, Tanja C
AU - Drummen, Mathijs
AU - Macdonald, Ian
AU - Jalo, Elli
AU - Siig-Vestentoft, Pia
AU - Martinez, J Alfredo
AU - Handjiev-Darlenska, Teodora
AU - Brand-Miller, Jennie
AU - Poppitt, Sally
AU - Stratton, Gareth
AU - Fogelholm, Mikael
AU - Pietiläinen, Kirsi H
AU - Taylor, Moira
AU - Navas-Carretero, Santiago
AU - Winkens, Bjorn
AU - Handjiev, Svetoslav
AU - Muirhead, Roslyn
AU - Silvestre, Marta
AU - Swindell, Nils
AU - Huttunen-Lenz, Maija
AU - Schlicht, Wolfgang
AU - Lam, Tony
AU - Sundvall, Jouko
AU - Råman, Laura
AU - Feskens, Edith
AU - Larssen, Thomas-Meinert
AU - Tremblay, Angelo
AU - Raben, Anne
AU - Westerterp-Plantenga, Margriet
N1 - © 2021 by the American Diabetes Association.
PY - 2021/7
Y1 - 2021/7
N2 - OBJECTIVE: Stress, sleep, eating behavior, and physical activity are associated with weight change and insulin resistance (IR). The aim of this analysis was the assessment of the overall and sex-specific associations of psychobehavioral variables throughout the 3-year PREVIEW intervention using the homeostatic model assessment of IR (HOMA-IR), BMI, and length of time in the study.RESEARCH DESIGN AND METHODS: Associations of psychobehavioral variables, including stress, mood, eating behavior, physical activity (PA), and sleep, with BMI, HOMA-IR, and time spent in the study were assessed in 2,184 participants with prediabetes and overweight/obesity (n = 706 men; n = 1,478 women) during a 3-year lifestyle intervention using linear mixed modeling and general linear modeling. The study was a randomized multicenter trial using a 2 × 2 diet-by-PA design.RESULTS: Overall, cognitive restraint and PA increased during the intervention compared with baseline, whereas BMI, HOMA-IR, disinhibition, hunger, and sleepiness decreased (all P < 0.05). Cognitive restraint and PA were negatively, whereas disinhibition, hunger, stress, and total mood disturbance were positively, associated with both BMI and HOMA-IR. Sleep duration, low sleep quality, total mood disturbance, disinhibition, and hunger scores were positively associated with HOMA-IR for men only. Participants who dropped out at 6 months had higher stress and total mood disturbance scores at baseline and throughout their time spent in the study compared with study completers.CONCLUSIONS: Eating behavior and PA, control of stress, mood disturbance, and sleep characteristics were associated with BMI, HOMA-IR, and time spent in the study, with different effects in men and women during the PREVIEW lifestyle intervention study.
AB - OBJECTIVE: Stress, sleep, eating behavior, and physical activity are associated with weight change and insulin resistance (IR). The aim of this analysis was the assessment of the overall and sex-specific associations of psychobehavioral variables throughout the 3-year PREVIEW intervention using the homeostatic model assessment of IR (HOMA-IR), BMI, and length of time in the study.RESEARCH DESIGN AND METHODS: Associations of psychobehavioral variables, including stress, mood, eating behavior, physical activity (PA), and sleep, with BMI, HOMA-IR, and time spent in the study were assessed in 2,184 participants with prediabetes and overweight/obesity (n = 706 men; n = 1,478 women) during a 3-year lifestyle intervention using linear mixed modeling and general linear modeling. The study was a randomized multicenter trial using a 2 × 2 diet-by-PA design.RESULTS: Overall, cognitive restraint and PA increased during the intervention compared with baseline, whereas BMI, HOMA-IR, disinhibition, hunger, and sleepiness decreased (all P < 0.05). Cognitive restraint and PA were negatively, whereas disinhibition, hunger, stress, and total mood disturbance were positively, associated with both BMI and HOMA-IR. Sleep duration, low sleep quality, total mood disturbance, disinhibition, and hunger scores were positively associated with HOMA-IR for men only. Participants who dropped out at 6 months had higher stress and total mood disturbance scores at baseline and throughout their time spent in the study compared with study completers.CONCLUSIONS: Eating behavior and PA, control of stress, mood disturbance, and sleep characteristics were associated with BMI, HOMA-IR, and time spent in the study, with different effects in men and women during the PREVIEW lifestyle intervention study.
KW - Body Mass Index
KW - Female
KW - Humans
KW - Insulin Resistance
KW - Life Style
KW - Male
KW - Prediabetic State
UR - http://www.scopus.com/inward/record.url?scp=85121158002&partnerID=8YFLogxK
U2 - 10.2337/dc21-0059
DO - 10.2337/dc21-0059
M3 - Journal article
C2 - 34088702
SN - 1935-5548
VL - 44
SP - 1491
EP - 1498
JO - Diabetes Care
JF - Diabetes Care
IS - 7
ER -