Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Association of preoperative anaemia with postoperative morbidity and mortality: an observational cohort study in low-, middle-, and high-income countries

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Minimising droplet and virus spread during and after tracheal extubation

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  2. Enhanced recovery after surgery components and perioperative outcomes: a nationwide observational study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Sphenopalatine ganglion block for the treatment of postdural puncture headache: a randomised, blinded, clinical trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Use of the GRADE approach in systematic reviews and guidelines

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  1. Long-term Survival and Cognitive Function According to Blood Pressure Management During Cardiac Surgery. A Follow-up

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Maintaining Competence in Airway Management

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Impact of Physician-staffed Helicopters on Pre-hospital Patient Outcomes: a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Cervical Spine Clearance in Trauma Patients with an Unreliable Physical Examination

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Red blood cell transfusion in surgery: an observational study of the trends in the USA from 2011 to 2016

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • A J Fowler
  • T Ahmad
  • T E F Abbott
  • H D Torrance
  • P F Wouters
  • S De Hert
  • S M Lobo
  • L S Rasmussen
  • G Della Rocca
  • W S Beattie
  • D N Wijeysundera
  • R M Pearse
  • International Surgical Outcomes Study Group
Vis graf over relationer

BACKGROUND: Anaemia is associated with poor postoperative outcomes, but few studies have described the impact of preoperative anaemia in low- and middle- (LMICs), and high-income countries (HICs).

METHODS: This was a planned analysis of data collected during an international 7 day cohort study of adults undergoing elective inpatient surgery. The primary outcome was in-hospital death, and the secondary outcomes were in-hospital complications. Anaemia was defined as haemoglobin <12 g dl-1 for females and <13 g dl-1 for males. Hierarchical three-level mixed-effect logistic regression models were constructed to examine the associations between preoperative anaemia and outcomes.

RESULTS: We included 38 770 patients from 474 hospitals in 27 countries of whom 11 675 (30.1%) were anaemic. Of these, 6886 (17.8%) patients suffered a complication and 198 (0.5%) died. Patients from LMICs were younger with lower ASA physical status scores, but a similar prevalence of anaemia [LMIC: 5072 (32.5%) of 15 585 vs HIC: 6603 (28.5%) of 23 185]. Patients with moderate [odds ratio (OR): 2.70; 95% confidence interval (CI): 1.88-3.87] and severe anaemia (OR: 4.09; 95% CI: 1.90-8.81) were at an increased risk of death in both HIC and LMICs. Complication rates increased with the severity of anaemia. Compared with patients in LMICs, those in HICs experienced fewer complications after an interaction term analysis [LMIC (OR: 0.92; 95% CI: 0.87-0.97) vs HIC (OR: 0.86; 95% CI: 0.84-0.87); P<0.01].

CONCLUSIONS: One-third of patients undergoing elective surgery are anaemic. These patients have an increased risk of complications and death. The prevalence of anaemia is similar amongst patients in LMICs despite their younger age and lower risk profile.

CLINICAL TRIAL REGISTRATION: ISRCTN51817007.

OriginalsprogEngelsk
TidsskriftBritish Journal of Anaesthesia
Vol/bind121
Udgave nummer6
Sider (fra-til)1227-1235
Antal sider9
ISSN0007-0912
DOI
StatusUdgivet - dec. 2018

ID: 55649616