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Association of In Utero Persistent Organic Pollutant Exposure with Placental Thyroid Hormones

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Li, Zhong-Min ; Hernandez-Moreno, David ; Main, Katharina Maria ; Skakkebæk, Niels Erik ; Kiviranta, Hannu ; Toppari, Jorma ; Feldt-Rasmussen, Ulla ; Shen, Heqing ; Schramm, Karl-Werner ; De Angelis, Meri. / Association of In Utero Persistent Organic Pollutant Exposure with Placental Thyroid Hormones. I: Endocrinology. 2018 ; Bind 159, Nr. 10. s. 3473-3481.

Bibtex

@article{ee20cd67af344636977d80430bc2fe88,
title = "Association of In Utero Persistent Organic Pollutant Exposure with Placental Thyroid Hormones",
abstract = "In utero exposure to persistent organic pollutants (POPs) can result in thyroid function disorder, leading to concerns about their impact on fetal and neonatal development. The present study was performed to investigate the associations between placental levels of various POPs and thyroid hormones (THs). In a prospective Danish study initially established for assessing congenital cryptorchidism, 58 placenta samples were collected from mothers of boys born with (28) and without (30) cryptorchidism. The concentrations of polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs), organotin chemicals (OTCs), organochlorine pesticides (OCPs), thyroxine (T4), 3,3',5-triiodothyronine (T3), and 3,3',5'-triiodothyronine (rT3) were measured. The associations between placental THs and various POPs were analyzed using multiple linear regression. Five PBDEs, 35 PCBs, 14 PCDD/Fs, 3 OTCs, 25 OCPs, T4, T3, and rT3 were measured. No correlation between THs and the odds of cryptorchidism was found. Several POPs were significantly associated with THs: a) T4 was inversely associated with BDEs 99, 100, ΣPBDE, and 2378-TeCDD, and positively associated with 1234678-HpCDF; b) T3 was positively associated with 2378-TeCDF and 12378-PeCDF; c) rT3 was positively associated with PCB 81, 12378-PeCDF and 234678-HxCDF, and inversely associated with tributyltin (TBT), ΣOTC, and methoxychlor (MOC). These results revealed that POP exposures were associated with TH levels in placenta, a possible mechanism for the impacts of POP exposures on children's growth and development. This study provides new insight into the complexity of thyroid-disrupting properties of POPs. More research is needed to elucidate the biological consequences of POP exposures.",
author = "Zhong-Min Li and David Hernandez-Moreno and Main, {Katharina Maria} and Skakkeb{\ae}k, {Niels Erik} and Hannu Kiviranta and Jorma Toppari and Ulla Feldt-Rasmussen and Heqing Shen and Karl-Werner Schramm and {De Angelis}, Meri",
year = "2018",
doi = "10.1210/en.2018-00542",
language = "English",
volume = "159",
pages = "3473--3481",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The/Endocrine Society",
number = "10",

}

RIS

TY - JOUR

T1 - Association of In Utero Persistent Organic Pollutant Exposure with Placental Thyroid Hormones

AU - Li, Zhong-Min

AU - Hernandez-Moreno, David

AU - Main, Katharina Maria

AU - Skakkebæk, Niels Erik

AU - Kiviranta, Hannu

AU - Toppari, Jorma

AU - Feldt-Rasmussen, Ulla

AU - Shen, Heqing

AU - Schramm, Karl-Werner

AU - De Angelis, Meri

PY - 2018

Y1 - 2018

N2 - In utero exposure to persistent organic pollutants (POPs) can result in thyroid function disorder, leading to concerns about their impact on fetal and neonatal development. The present study was performed to investigate the associations between placental levels of various POPs and thyroid hormones (THs). In a prospective Danish study initially established for assessing congenital cryptorchidism, 58 placenta samples were collected from mothers of boys born with (28) and without (30) cryptorchidism. The concentrations of polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs), organotin chemicals (OTCs), organochlorine pesticides (OCPs), thyroxine (T4), 3,3',5-triiodothyronine (T3), and 3,3',5'-triiodothyronine (rT3) were measured. The associations between placental THs and various POPs were analyzed using multiple linear regression. Five PBDEs, 35 PCBs, 14 PCDD/Fs, 3 OTCs, 25 OCPs, T4, T3, and rT3 were measured. No correlation between THs and the odds of cryptorchidism was found. Several POPs were significantly associated with THs: a) T4 was inversely associated with BDEs 99, 100, ΣPBDE, and 2378-TeCDD, and positively associated with 1234678-HpCDF; b) T3 was positively associated with 2378-TeCDF and 12378-PeCDF; c) rT3 was positively associated with PCB 81, 12378-PeCDF and 234678-HxCDF, and inversely associated with tributyltin (TBT), ΣOTC, and methoxychlor (MOC). These results revealed that POP exposures were associated with TH levels in placenta, a possible mechanism for the impacts of POP exposures on children's growth and development. This study provides new insight into the complexity of thyroid-disrupting properties of POPs. More research is needed to elucidate the biological consequences of POP exposures.

AB - In utero exposure to persistent organic pollutants (POPs) can result in thyroid function disorder, leading to concerns about their impact on fetal and neonatal development. The present study was performed to investigate the associations between placental levels of various POPs and thyroid hormones (THs). In a prospective Danish study initially established for assessing congenital cryptorchidism, 58 placenta samples were collected from mothers of boys born with (28) and without (30) cryptorchidism. The concentrations of polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs), organotin chemicals (OTCs), organochlorine pesticides (OCPs), thyroxine (T4), 3,3',5-triiodothyronine (T3), and 3,3',5'-triiodothyronine (rT3) were measured. The associations between placental THs and various POPs were analyzed using multiple linear regression. Five PBDEs, 35 PCBs, 14 PCDD/Fs, 3 OTCs, 25 OCPs, T4, T3, and rT3 were measured. No correlation between THs and the odds of cryptorchidism was found. Several POPs were significantly associated with THs: a) T4 was inversely associated with BDEs 99, 100, ΣPBDE, and 2378-TeCDD, and positively associated with 1234678-HpCDF; b) T3 was positively associated with 2378-TeCDF and 12378-PeCDF; c) rT3 was positively associated with PCB 81, 12378-PeCDF and 234678-HxCDF, and inversely associated with tributyltin (TBT), ΣOTC, and methoxychlor (MOC). These results revealed that POP exposures were associated with TH levels in placenta, a possible mechanism for the impacts of POP exposures on children's growth and development. This study provides new insight into the complexity of thyroid-disrupting properties of POPs. More research is needed to elucidate the biological consequences of POP exposures.

U2 - 10.1210/en.2018-00542

DO - 10.1210/en.2018-00542

M3 - Journal article

C2 - 30059991

VL - 159

SP - 3473

EP - 3481

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 10

ER -

ID: 55073067