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Association of History of Psychopathology With Accelerated Aging at Midlife

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Harvard

Wertz, J, Caspi, A, Ambler, A, Broadbent, J, Hancox, RJ, Harrington, H, Hogan, S, Houts, RM, Leung, JH, Poulton, R, Purdy, SC, Ramrakha, S, Rasmussen, LJH, Richmond-Rakerd, LS, Thorne, PR, Wilson, GA & Moffitt, TE 2021, 'Association of History of Psychopathology With Accelerated Aging at Midlife', JAMA Psychiatry, bind 78, nr. 5, 4626, s. 530-539. https://doi.org/10.1001/jamapsychiatry.2020.4626

APA

Wertz, J., Caspi, A., Ambler, A., Broadbent, J., Hancox, R. J., Harrington, H., Hogan, S., Houts, R. M., Leung, J. H., Poulton, R., Purdy, S. C., Ramrakha, S., Rasmussen, L. J. H., Richmond-Rakerd, L. S., Thorne, P. R., Wilson, G. A., & Moffitt, T. E. (2021). Association of History of Psychopathology With Accelerated Aging at Midlife. JAMA Psychiatry, 78(5), 530-539. [4626]. https://doi.org/10.1001/jamapsychiatry.2020.4626

CBE

Wertz J, Caspi A, Ambler A, Broadbent J, Hancox RJ, Harrington H, Hogan S, Houts RM, Leung JH, Poulton R, Purdy SC, Ramrakha S, Rasmussen LJH, Richmond-Rakerd LS, Thorne PR, Wilson GA, Moffitt TE. 2021. Association of History of Psychopathology With Accelerated Aging at Midlife. JAMA Psychiatry. 78(5):530-539. https://doi.org/10.1001/jamapsychiatry.2020.4626

MLA

Vancouver

Wertz J, Caspi A, Ambler A, Broadbent J, Hancox RJ, Harrington H o.a. Association of History of Psychopathology With Accelerated Aging at Midlife. JAMA Psychiatry. 2021 maj 1;78(5):530-539. 4626. https://doi.org/10.1001/jamapsychiatry.2020.4626

Author

Wertz, Jasmin ; Caspi, Avshalom ; Ambler, Antony ; Broadbent, Jonathan ; Hancox, Robert J ; Harrington, HonaLee ; Hogan, Sean ; Houts, Renate M ; Leung, Joan H ; Poulton, Richie ; Purdy, Suzanne C ; Ramrakha, Sandhya ; Rasmussen, Line Jee Hartmann ; Richmond-Rakerd, Leah S ; Thorne, Peter R ; Wilson, Graham A ; Moffitt, Terrie E. / Association of History of Psychopathology With Accelerated Aging at Midlife. I: JAMA Psychiatry. 2021 ; Bind 78, Nr. 5. s. 530-539.

Bibtex

@article{537c29c7eddf4d609ad066954c0f2cb9,
title = "Association of History of Psychopathology With Accelerated Aging at Midlife",
abstract = "Importance: Individuals with mental disorders are at an elevated risk of developing chronic age-related physical diseases. However, it is not clear whether psychopathology is also associated with processes of accelerated aging that precede the onset of age-related disease. Objective: To test the hypothesis that a history of psychopathology is associated with indicators of accelerated aging at midlife. Design, Setting, and Participants: This prospective cohort study was based on the Dunedin Multidisciplinary Health and Development Study, a population-representative birth cohort of 1037 individuals born between April 1, 1972, and March 31, 1973, in Dunedin, New Zealand. Members were followed up to age 45 years (until April 2019). Data were analyzed from January 6 to December 7, 2020. Exposures: Mental disorders were assessed in 6 diagnostic assessments from ages 18 to 45 years and transformed through confirmatory factor analysis into continuous measures of general psychopathology (p-factor) and dimensions of internalizing, externalizing, and thought disorders (all standardized to a mean [SD] of 100 [15]). Main Outcomes and Measures: Signs of aging (biological pace of aging; declines in sensory, motor, and cognitive functioning; and facial age) were assessed up to age 45 years using previously validated measures including biomarkers, clinical tests, and self-reports. Results: Of the original 1037 cohort participants, 997 were still alive at age 45 years, of whom 938 (94%) were assessed (474 men [50.5%]). Participants who had experienced more psychopathology exhibited a faster pace of biological aging (β, 0.27; 95% CI, 0.21-0.33; P <.01); experienced more difficulties with hearing (β, 0.18; 95% CI, 0.12-0.24; P <.01), vision (β, 0.08; 95% CI, 0.01-0.14; P <.05), balance (β, 0.20; 95% CI, 0.14-0.26; P <.01), and motor functioning (β, 0.19; 95% CI, 0.12-0.25; P <.01); experienced more cognitive difficulties (β, 0.24; 95% CI, 0.18-0.31; P <.01); and were rated as looking older (β, 0.20; 95% CI, 0.14-0.26; P <.01). Associations persisted after controlling for sex, childhood health indicators, maltreatment, and socioeconomic status and after taking into account being overweight, smoking, use of antipsychotic medication, and the presence of physical disease. Tests of diagnostic specificity revealed that associations were generalizable across externalizing, internalizing, and thought disorders. Conclusions and Relevance: In this cohort study, a history of psychopathology was associated with accelerated aging at midlife, years before the typical onset of age-related diseases. This link is not specific to any particular disorder family but generalizes across disorders. Prevention of psychopathology and monitoring of individuals with mental disorders for signs of accelerated aging may have the potential to reduce health inequalities and extend healthy lives..",
author = "Jasmin Wertz and Avshalom Caspi and Antony Ambler and Jonathan Broadbent and Hancox, {Robert J} and HonaLee Harrington and Sean Hogan and Houts, {Renate M} and Leung, {Joan H} and Richie Poulton and Purdy, {Suzanne C} and Sandhya Ramrakha and Rasmussen, {Line Jee Hartmann} and Richmond-Rakerd, {Leah S} and Thorne, {Peter R} and Wilson, {Graham A} and Moffitt, {Terrie E}",
note = "Publisher Copyright: {\textcopyright} 2021 American Medical Association. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = may,
day = "1",
doi = "10.1001/jamapsychiatry.2020.4626",
language = "English",
volume = "78",
pages = "530--539",
journal = "Archives of General Psychiatry",
issn = "2168-622X",
publisher = "American Medical Association",
number = "5",

}

RIS

TY - JOUR

T1 - Association of History of Psychopathology With Accelerated Aging at Midlife

AU - Wertz, Jasmin

AU - Caspi, Avshalom

AU - Ambler, Antony

AU - Broadbent, Jonathan

AU - Hancox, Robert J

AU - Harrington, HonaLee

AU - Hogan, Sean

AU - Houts, Renate M

AU - Leung, Joan H

AU - Poulton, Richie

AU - Purdy, Suzanne C

AU - Ramrakha, Sandhya

AU - Rasmussen, Line Jee Hartmann

AU - Richmond-Rakerd, Leah S

AU - Thorne, Peter R

AU - Wilson, Graham A

AU - Moffitt, Terrie E

N1 - Publisher Copyright: © 2021 American Medical Association. All rights reserved. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/5/1

Y1 - 2021/5/1

N2 - Importance: Individuals with mental disorders are at an elevated risk of developing chronic age-related physical diseases. However, it is not clear whether psychopathology is also associated with processes of accelerated aging that precede the onset of age-related disease. Objective: To test the hypothesis that a history of psychopathology is associated with indicators of accelerated aging at midlife. Design, Setting, and Participants: This prospective cohort study was based on the Dunedin Multidisciplinary Health and Development Study, a population-representative birth cohort of 1037 individuals born between April 1, 1972, and March 31, 1973, in Dunedin, New Zealand. Members were followed up to age 45 years (until April 2019). Data were analyzed from January 6 to December 7, 2020. Exposures: Mental disorders were assessed in 6 diagnostic assessments from ages 18 to 45 years and transformed through confirmatory factor analysis into continuous measures of general psychopathology (p-factor) and dimensions of internalizing, externalizing, and thought disorders (all standardized to a mean [SD] of 100 [15]). Main Outcomes and Measures: Signs of aging (biological pace of aging; declines in sensory, motor, and cognitive functioning; and facial age) were assessed up to age 45 years using previously validated measures including biomarkers, clinical tests, and self-reports. Results: Of the original 1037 cohort participants, 997 were still alive at age 45 years, of whom 938 (94%) were assessed (474 men [50.5%]). Participants who had experienced more psychopathology exhibited a faster pace of biological aging (β, 0.27; 95% CI, 0.21-0.33; P <.01); experienced more difficulties with hearing (β, 0.18; 95% CI, 0.12-0.24; P <.01), vision (β, 0.08; 95% CI, 0.01-0.14; P <.05), balance (β, 0.20; 95% CI, 0.14-0.26; P <.01), and motor functioning (β, 0.19; 95% CI, 0.12-0.25; P <.01); experienced more cognitive difficulties (β, 0.24; 95% CI, 0.18-0.31; P <.01); and were rated as looking older (β, 0.20; 95% CI, 0.14-0.26; P <.01). Associations persisted after controlling for sex, childhood health indicators, maltreatment, and socioeconomic status and after taking into account being overweight, smoking, use of antipsychotic medication, and the presence of physical disease. Tests of diagnostic specificity revealed that associations were generalizable across externalizing, internalizing, and thought disorders. Conclusions and Relevance: In this cohort study, a history of psychopathology was associated with accelerated aging at midlife, years before the typical onset of age-related diseases. This link is not specific to any particular disorder family but generalizes across disorders. Prevention of psychopathology and monitoring of individuals with mental disorders for signs of accelerated aging may have the potential to reduce health inequalities and extend healthy lives..

AB - Importance: Individuals with mental disorders are at an elevated risk of developing chronic age-related physical diseases. However, it is not clear whether psychopathology is also associated with processes of accelerated aging that precede the onset of age-related disease. Objective: To test the hypothesis that a history of psychopathology is associated with indicators of accelerated aging at midlife. Design, Setting, and Participants: This prospective cohort study was based on the Dunedin Multidisciplinary Health and Development Study, a population-representative birth cohort of 1037 individuals born between April 1, 1972, and March 31, 1973, in Dunedin, New Zealand. Members were followed up to age 45 years (until April 2019). Data were analyzed from January 6 to December 7, 2020. Exposures: Mental disorders were assessed in 6 diagnostic assessments from ages 18 to 45 years and transformed through confirmatory factor analysis into continuous measures of general psychopathology (p-factor) and dimensions of internalizing, externalizing, and thought disorders (all standardized to a mean [SD] of 100 [15]). Main Outcomes and Measures: Signs of aging (biological pace of aging; declines in sensory, motor, and cognitive functioning; and facial age) were assessed up to age 45 years using previously validated measures including biomarkers, clinical tests, and self-reports. Results: Of the original 1037 cohort participants, 997 were still alive at age 45 years, of whom 938 (94%) were assessed (474 men [50.5%]). Participants who had experienced more psychopathology exhibited a faster pace of biological aging (β, 0.27; 95% CI, 0.21-0.33; P <.01); experienced more difficulties with hearing (β, 0.18; 95% CI, 0.12-0.24; P <.01), vision (β, 0.08; 95% CI, 0.01-0.14; P <.05), balance (β, 0.20; 95% CI, 0.14-0.26; P <.01), and motor functioning (β, 0.19; 95% CI, 0.12-0.25; P <.01); experienced more cognitive difficulties (β, 0.24; 95% CI, 0.18-0.31; P <.01); and were rated as looking older (β, 0.20; 95% CI, 0.14-0.26; P <.01). Associations persisted after controlling for sex, childhood health indicators, maltreatment, and socioeconomic status and after taking into account being overweight, smoking, use of antipsychotic medication, and the presence of physical disease. Tests of diagnostic specificity revealed that associations were generalizable across externalizing, internalizing, and thought disorders. Conclusions and Relevance: In this cohort study, a history of psychopathology was associated with accelerated aging at midlife, years before the typical onset of age-related diseases. This link is not specific to any particular disorder family but generalizes across disorders. Prevention of psychopathology and monitoring of individuals with mental disorders for signs of accelerated aging may have the potential to reduce health inequalities and extend healthy lives..

UR - http://www.scopus.com/inward/record.url?scp=85101257915&partnerID=8YFLogxK

U2 - 10.1001/jamapsychiatry.2020.4626

DO - 10.1001/jamapsychiatry.2020.4626

M3 - Journal article

C2 - 33595619

VL - 78

SP - 530

EP - 539

JO - Archives of General Psychiatry

JF - Archives of General Psychiatry

SN - 2168-622X

IS - 5

M1 - 4626

ER -

ID: 62310070