Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Association of High-Dose Vitamin D Supplementation During Pregnancy With the Risk of Enamel Defects in Offspring: A 6-Year Follow-up of a Randomized Clinical Trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Association Between Fexofenadine Use During Pregnancy and Fetal Outcomes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Major Concerns Over Improving Measurement of Inflammation Remain-Reply

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Association of Adverse Experiences and Exposure to Violence in Childhood and Adolescence With Inflammatory Burden in Young People

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Prenatal Vitamin D Supplementation to Improve Health in Offspring

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Distinct immune phenotypes in infants developing asthma during childhood

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Prenatal dietary supplements influence the infant airway microbiota in a randomized factorial clinical trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Virulent coliphages in 1-year-old children fecal samples are fewer, but more infectious than temperate coliphages

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Importance: Enamel defects of developmental origin affect up to 38% of schoolchildren and is recognized as a global public health challenge. The impaired enamel formation results in pain owing to hypersensitivity, posteruptive breakdowns, rapid caries progression, and extractions in some cases. The etiology is unknown; therefore, prevention is currently not possible.

Objective: To assess the association of a high-dose vitamin D supplementation in pregnant women with enamel defects and caries in their offspring.

Design, Setting, and Participants: Post hoc analysis of a double-blind, single-center, randomized clinical trial, the Copenhagen Prospective Studies on Asthma in Childhood 2010 cohort (COPSAC2010). Enrollment began March 2009 and included 623 women recruited at 24 weeks of pregnancy and 588 of their children. A dental examination was completed at age 6 years in 496 of 588 children (84%). Data were analyzed in 2018.

Intervention: High-dose vitamin D3 (2400 IU/d; N = 315) or matching placebo tablets (N = 308) from pregnancy week 24 to 1 week post partum. In addition, all women received 400 IU/d of vitamin D3 as part of standard care.

Main Outcomes and Measures: Enamel defect was defined as having at least 1 molar affected by demarcated opacity, enamel breakdown, and/or atypical restoration. Caries was defined as decayed, missing, or filled surfaces in both the deciduous and permanent dentitions (World Health Organization standard).

Results: The risk of enamel defects in the permanent dentition was lower in the offspring of mothers who received high-dose vitamin D supplementation during pregnancy compared with standard dose (15.1% [n = 26 of 172] vs 27.5% [n = 44 of 160]; odds ratio, 0.47; 95% CI, 0.27-0.81). A similar association was observed for the deciduous dentition (8.6% [n = 21 of 244] vs 15.9% [n = 40 of 252]; odds ratio, 0.50; 95% CI, 0.28-0.87). There was no association between supplementation and caries.

Conclusions and Relevance: High-dose vitamin D supplementation during pregnancy was associated with approximately 50% reduced odds of enamel defects in the offspring. This suggests prenatal vitamin D supplementation as a preventive intervention for enamel defects, with a clinically important association with dental health.

Trial Registration: ClinicalTrials.gov identifier: NCT00856947.

OriginalsprogEngelsk
TidsskriftJAMA Pediatrics
Vol/bind173
Udgave nummer10
Sider (fra-til)924-930
Antal sider7
ISSN2168-6203
DOI
StatusUdgivet - 1 okt. 2019

ID: 57877897