Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Common variants in breast cancer risk loci predispose to distinct tumor subtypes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Gene–gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. I am hiQ—a novel pair of accuracy indices for imputed genotypes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Anna Morra
  • Maria Escala-Garcia
  • Jonathan Beesley
  • Renske Keeman
  • Sander Canisius
  • Thomas U Ahearn
  • Irene L Andrulis
  • Hoda Anton-Culver
  • Volker Arndt
  • Paul L Auer
  • Annelie Augustinsson
  • Laura E Beane Freeman
  • Heiko Becher
  • Matthias W Beckmann
  • Sabine Behrens
  • Stig E Bojesen
  • Manjeet K Bolla
  • Hermann Brenner
  • Thomas Brüning
  • Saundra S Buys
  • Bette Caan
  • Daniele Campa
  • Federico Canzian
  • Jose E Castelao
  • Jenny Chang-Claude
  • Stephen J Chanock
  • Ting-Yuan David Cheng
  • Christine L Clarke
  • Sarah V Colonna
  • Fergus J Couch
  • Angela Cox
  • Simon S Cross
  • Kamila Czene
  • Mary B Daly
  • Joe Dennis
  • Thilo Dörk
  • Laure Dossus
  • Alison M Dunning
  • Miriam Dwek
  • Diana M Eccles
  • Arif B Ekici
  • A Heather Eliassen
  • Mikael Eriksson
  • D Gareth Evans
  • Peter A Fasching
  • Henrik Flyger
  • Lin Fritschi
  • Manuela Gago-Dominguez
  • Sune F Nielsen
  • Børge G Nordestgaard
  • NBCS Collaborators
Vis graf over relationer

BACKGROUND: Given the high heterogeneity among breast tumors, associations between common germline genetic variants and survival that may exist within specific subgroups could go undetected in an unstratified set of breast cancer patients.

METHODS: We performed genome-wide association analyses within 15 subgroups of breast cancer patients based on prognostic factors, including hormone receptors, tumor grade, age, and type of systemic treatment. Analyses were based on 91,686 female patients of European ancestry from the Breast Cancer Association Consortium, including 7531 breast cancer-specific deaths over a median follow-up of 8.1 years. Cox regression was used to assess associations of common germline variants with 15-year and 5-year breast cancer-specific survival. We assessed the probability of these associations being true positives via the Bayesian false discovery probability (BFDP < 0.15).

RESULTS: Evidence of associations with breast cancer-specific survival was observed in three patient subgroups, with variant rs5934618 in patients with grade 3 tumors (15-year-hazard ratio (HR) [95% confidence interval (CI)] 1.32 [1.20, 1.45], P = 1.4E-08, BFDP = 0.01, per G allele); variant rs4679741 in patients with ER-positive tumors treated with endocrine therapy (15-year-HR [95% CI] 1.18 [1.11, 1.26], P = 1.6E-07, BFDP = 0.09, per G allele); variants rs1106333 (15-year-HR [95% CI] 1.68 [1.39,2.03], P = 5.6E-08, BFDP = 0.12, per A allele) and rs78754389 (5-year-HR [95% CI] 1.79 [1.46,2.20], P = 1.7E-08, BFDP = 0.07, per A allele), in patients with ER-negative tumors treated with chemotherapy.

CONCLUSIONS: We found evidence of four loci associated with breast cancer-specific survival within three patient subgroups. There was limited evidence for the existence of associations in other patient subgroups. However, the power for many subgroups is limited due to the low number of events. Even so, our results suggest that the impact of common germline genetic variants on breast cancer-specific survival might be limited.

OriginalsprogEngelsk
Artikelnummer86
TidsskriftBreast Cancer Research
Vol/bind23
Udgave nummer1
Sider (fra-til)86
Antal sider1
ISSN1465-542X
DOI
StatusUdgivet - 18 aug. 2021

ID: 67234656