Association of ficolin-3 with severity and outcome of chronic heart failure

Zoltán Prohászka; Lea Munthe-Fog; Thor Ueland; Timea Gombos; Arne Yndestad; Zsolt Förhécz; Mikkel-Ole Skjoedt; Zoltan Pozsonyi; Alice Gustavsen; Lívia Jánoskuti; István Karádi; Lars Gullestad; Christen P Dahl; Erik T Askevold; George Füst; Pål Aukrust; Tom E Mollnes; Peter Garred

doi:10.1371/journal.pone.0060976

Association of ficolin-3 with severity and outcome of chronic heart failure

Zoltán Prohászka, Lea Munthe-Fog, Thor Ueland, Timea Gombos, Arne Yndestad, Zsolt Förhécz, Mikkel-Ole Skjoedt, Zoltan Pozsonyi, Alice Gustavsen, Lívia Jánoskuti, István Karádi, Lars Gullestad, Christen P Dahl, Erik T Askevold, George Füst, Pål Aukrust, Tom E Mollnes, Peter Garred

Afdeling for Klinisk Immunologi DIA

35 Citationer (Scopus)

Abstract

Inflammatory mechanisms involving complement activation has been shown to take part in the pathophysiology of congestive heart failure, but the initiating mechanisms are unknown. We hypothesized that the main initiator molecules of the lectin complement pathway mannose-binding lectin (MBL), ficolin-2 and ficolin-3 were related to disease severity and outcome in chronic heart failure.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	8
Udgave nummer	4
Sider (fra-til)	e60976
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0060976
Status	Udgivet - 2013

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Prohászka, Z., Munthe-Fog, L., Ueland, T., Gombos, T., Yndestad, A., Förhécz, Z., Skjoedt, M.-O., Pozsonyi, Z., Gustavsen, A., Jánoskuti, L., Karádi, I., Gullestad, L., Dahl, C. P., Askevold, E. T., Füst, G., Aukrust, P., Mollnes, T. E., & Garred, P. (2013). Association of ficolin-3 with severity and outcome of chronic heart failure. P L o S One, 8(4), e60976. https://doi.org/10.1371/journal.pone.0060976

Prohászka, Z, Munthe-Fog, L, Ueland, T, Gombos, T, Yndestad, A, Förhécz, Z, Skjoedt, M-O, Pozsonyi, Z, Gustavsen, A, Jánoskuti, L, Karádi, I, Gullestad, L, Dahl, CP, Askevold, ET, Füst, G, Aukrust, P, Mollnes, TE & Garred, P 2013, 'Association of ficolin-3 with severity and outcome of chronic heart failure', P L o S One, bind 8, nr. 4, s. e60976. https://doi.org/10.1371/journal.pone.0060976

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abstract = "Inflammatory mechanisms involving complement activation has been shown to take part in the pathophysiology of congestive heart failure, but the initiating mechanisms are unknown. We hypothesized that the main initiator molecules of the lectin complement pathway mannose-binding lectin (MBL), ficolin-2 and ficolin-3 were related to disease severity and outcome in chronic heart failure.",

author = "Zolt{\'a}n Proh{\'a}szka and Lea Munthe-Fog and Thor Ueland and Timea Gombos and Arne Yndestad and Zsolt F{\"o}rh{\'e}cz and Mikkel-Ole Skjoedt and Zoltan Pozsonyi and Alice Gustavsen and L{\'i}via J{\'a}noskuti and Istv{\'a}n Kar{\'a}di and Lars Gullestad and Dahl, \{Christen P\} and Askevold, \{Erik T\} and George F{\"u}st and P{\aa}l Aukrust and Mollnes, \{Tom E\} and Peter Garred",

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doi = "10.1371/journal.pone.0060976",

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AU - Prohászka, Zoltán

AU - Munthe-Fog, Lea

AU - Ueland, Thor

AU - Gombos, Timea

AU - Yndestad, Arne

AU - Förhécz, Zsolt

AU - Skjoedt, Mikkel-Ole

AU - Pozsonyi, Zoltan

AU - Gustavsen, Alice

AU - Jánoskuti, Lívia

AU - Karádi, István

AU - Gullestad, Lars

AU - Dahl, Christen P

AU - Askevold, Erik T

AU - Füst, George

AU - Aukrust, Pål

AU - Mollnes, Tom E

AU - Garred, Peter

PY - 2013

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N2 - Inflammatory mechanisms involving complement activation has been shown to take part in the pathophysiology of congestive heart failure, but the initiating mechanisms are unknown. We hypothesized that the main initiator molecules of the lectin complement pathway mannose-binding lectin (MBL), ficolin-2 and ficolin-3 were related to disease severity and outcome in chronic heart failure.

AB - Inflammatory mechanisms involving complement activation has been shown to take part in the pathophysiology of congestive heart failure, but the initiating mechanisms are unknown. We hypothesized that the main initiator molecules of the lectin complement pathway mannose-binding lectin (MBL), ficolin-2 and ficolin-3 were related to disease severity and outcome in chronic heart failure.

UR - https://www.scopus.com/pages/publications/84876172339

U2 - 10.1371/journal.pone.0060976

DO - 10.1371/journal.pone.0060976

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SN - 1932-6203

VL - 8

SP - e60976

JO - P L o S One

JF - P L o S One

IS - 4

ER -

Association of ficolin-3 with severity and outcome of chronic heart failure

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