TY - JOUR
T1 - Association of fatal myocardial infarction with past level of physical activity
T2 - a pooled analysis of cohort studies
AU - Hansen, Kim Wadt
AU - Peytz, Nina
AU - Blokstra, Anneke
AU - Bojesen, Stig E
AU - Celis-Morales, Carlos
AU - Chrysohoou, Christina
AU - Clays, Els
AU - De Bacquer, Dirk
AU - Galatius, Søren
AU - Gray, Stuart R
AU - Ho, Frederick
AU - Kavousi, Maryam
AU - Koolhaas, Chantal M
AU - Kouvari, Matina
AU - Løchen, Maja-Lisa
AU - Marques-Vidal, Pedro
AU - Osler, Merete
AU - Panagiotakos, Demosthenes
AU - Pell, Jill P
AU - Sulo, Gerhard
AU - Tell, Grethe S
AU - Vassiliou, Vassilios
AU - Verschuren, W M Monique
AU - Prescott, Eva
N1 - © The Author(s) 2021. Published on behalf of the European Society of Cardiology. All rights reserved. For permissions, please email: [email protected].
PY - 2021/12/20
Y1 - 2021/12/20
N2 - AIMS: To assess the association between past level of physical activity (PA) and risk for death during the acute phase of myocardial infarction (MI) in a pooled analysis of cohort studies.METHODS AND RESULTS: European cohorts including participants with a baseline assessment of PA, conventional cardiovascular (CV) risk factors, and available follow-up on MI and death were eligible. Patients with an incident MI were included. Leisure-time PA was grouped as sedentary (<7 MET-hours), low (7-16 MET-hours), moderate (16.1-32 MET-hours), or high (>32 MET-hours) based on calculated net weekly energy expenditure. The main outcome measures were instant and 28-day case fatality of MI. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using multivariate random-effects models. Adjustments for age, sex, CV risk factors, alcohol consumption, and socioeconomic status were made. From 10 cohorts including a total of 1 495 254 participants, 28 140 patients with an incident MI comprised the study population. A total of 4976 (17.7%) died within 28 days-of these 3101 (62.3%) were classified as instant fatal MI. Compared with sedentary individuals, those with a higher level of PA had lower adjusted odds of instant fatal MI: low PA [OR, 0.79 (95% CI, 0.60-1.04)], moderate PA [0.67 (0.51-0.89)], and high PA [0.55 (0.40-0.76)]. Similar results were found for 28-day fatal MI: low PA [0.85 (0.71-1.03)], moderate PA [0.64 (0.51-0.80)], and high PA [0.72 (0.51-1.00)]. A low-to-moderate degree of heterogeneity was detected in the analysis of instant fatal MI (I2 = 47.3%), but not in that of 28-day fatal MI (I2 = 0.0%).CONCLUSION: A moderate-to-high level of PA was associated with a lower risk of instant and 28-day death in relation to a MI.
AB - AIMS: To assess the association between past level of physical activity (PA) and risk for death during the acute phase of myocardial infarction (MI) in a pooled analysis of cohort studies.METHODS AND RESULTS: European cohorts including participants with a baseline assessment of PA, conventional cardiovascular (CV) risk factors, and available follow-up on MI and death were eligible. Patients with an incident MI were included. Leisure-time PA was grouped as sedentary (<7 MET-hours), low (7-16 MET-hours), moderate (16.1-32 MET-hours), or high (>32 MET-hours) based on calculated net weekly energy expenditure. The main outcome measures were instant and 28-day case fatality of MI. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using multivariate random-effects models. Adjustments for age, sex, CV risk factors, alcohol consumption, and socioeconomic status were made. From 10 cohorts including a total of 1 495 254 participants, 28 140 patients with an incident MI comprised the study population. A total of 4976 (17.7%) died within 28 days-of these 3101 (62.3%) were classified as instant fatal MI. Compared with sedentary individuals, those with a higher level of PA had lower adjusted odds of instant fatal MI: low PA [OR, 0.79 (95% CI, 0.60-1.04)], moderate PA [0.67 (0.51-0.89)], and high PA [0.55 (0.40-0.76)]. Similar results were found for 28-day fatal MI: low PA [0.85 (0.71-1.03)], moderate PA [0.64 (0.51-0.80)], and high PA [0.72 (0.51-1.00)]. A low-to-moderate degree of heterogeneity was detected in the analysis of instant fatal MI (I2 = 47.3%), but not in that of 28-day fatal MI (I2 = 0.0%).CONCLUSION: A moderate-to-high level of PA was associated with a lower risk of instant and 28-day death in relation to a MI.
KW - Cohort studies
KW - Mortality
KW - Myocardial infarction
KW - Physical activity
KW - Pooled analysis
UR - http://www.scopus.com/inward/record.url?scp=85120656354&partnerID=8YFLogxK
U2 - 10.1093/eurjpc/zwaa146
DO - 10.1093/eurjpc/zwaa146
M3 - Journal article
C2 - 33564885
SN - 2047-4873
VL - 28
SP - 1590
EP - 1598
JO - European Journal of Preventive Cardiology
JF - European Journal of Preventive Cardiology
IS - 14
ER -