Association of competitive and recreational sport participation with cardiac events in patients with arrhythmogenic right ventricular cardiomyopathy: results from the North American multidisciplinary study of arrhythmogenic right ventricular cardiomyopathy

Anne-Christine Ruwald; Frank Marcus; N A Mark Estes; Mark Link; Scott McNitt; Bronislava Polonsky; Hugh Calkins; Jeffrey A Towbin; Arthur J Moss; Wojciech Zareba

doi:10.1093/eurheartj/ehv110

Association of competitive and recreational sport participation with cardiac events in patients with arrhythmogenic right ventricular cardiomyopathy: results from the North American multidisciplinary study of arrhythmogenic right ventricular cardiomyopathy

Anne-Christine Ruwald, Frank Marcus, N A Mark Estes, Mark Link, Scott McNitt, Bronislava Polonsky, Hugh Calkins, Jeffrey A Towbin, Arthur J Moss, Wojciech Zareba

233 Citationer (Scopus)

Abstract

AIMS: It has been proposed that competitive sport increases the risk of ventricular tachyarrhythmias (VTA) and death in patients with arrhythmogenic right-ventricular cardiomyopathy (ARVC). However, it is unknown whether this only applies to competitive sport or if recreational sports activity also increases the risk of VTA/death.

METHODS AND RESULTS: Probands diagnosed with ARVC according to the 2010 task force criteria for ARVC (n = 108) were included in the current analysis. At the time of enrolment, study participants were questioned about exercise level prior to and after ARVC diagnosis, within three categories of sports participation: competitive (n = 41), recreational (n = 48), and inactive (n = 19). Competitive sport was associated with a significantly higher risk of VTA/death when compared with both recreational sport [HR = 1.99 (1.21-3.28), P = 0.007] and inactive patients [HR = 2.05 (1.07-3.91), P = 0.030]. No increased risk of VTA/death was associated with recreational sport when compared with patients who were inactive [HR = 1.03 (0.54-1.97), P = 0.930]. Symptoms developed at an earlier age in patients who participated in competitive sport (30 ± 12 years), when compared with patients who participated in recreational sport (38 ± 17 years) (P = 0.015) and inactive patients (41 ± 11 years) (P = 0.002). No difference in age at first symptom was seen between patients who participated in recreational sport and inactive patients (P = 0.651).

CONCLUSION: Competitive sport was associated with a two-fold increased risk of VTA/death, and earlier presentation of symptoms, when compared with inactive patients, and to patients who participated in recreational sport. When compared with inactive patients, recreational sport was not associated with earlier onset of symptoms or increased risk of VTA/death.

CLINICAL TRIALSGOV IDENTIFIER: NCT00024505.

Originalsprog	Engelsk
Tidsskrift	European Heart Journal
Vol/bind	36
Udgave nummer	27
Sider (fra-til)	1735-43
Antal sider	9
ISSN	0195-668X
DOI	https://doi.org/10.1093/eurheartj/ehv110
Status	Udgivet - 14 jul. 2015

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10.1093/eurheartj/ehv110

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Citationsformater

Ruwald, A.-C., Marcus, F., Estes, N. A. M., Link, M., McNitt, S., Polonsky, B., Calkins, H., Towbin, J. A., Moss, A. J., & Zareba, W. (2015). Association of competitive and recreational sport participation with cardiac events in patients with arrhythmogenic right ventricular cardiomyopathy: results from the North American multidisciplinary study of arrhythmogenic right ventricular cardiomyopathy. European Heart Journal, 36(27), 1735-43. https://doi.org/10.1093/eurheartj/ehv110

Association of competitive and recreational sport participation with cardiac events in patients with arrhythmogenic right ventricular cardiomyopathy: results from the North American multidisciplinary study of arrhythmogenic right ventricular cardiomyopathy. / Ruwald, Anne-Christine; Marcus, Frank; Estes, N A Mark et al.
I: European Heart Journal, Bind 36, Nr. 27, 14.07.2015, s. 1735-43.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Ruwald, A-C, Marcus, F, Estes, NAM, Link, M, McNitt, S, Polonsky, B, Calkins, H, Towbin, JA, Moss, AJ & Zareba, W 2015, 'Association of competitive and recreational sport participation with cardiac events in patients with arrhythmogenic right ventricular cardiomyopathy: results from the North American multidisciplinary study of arrhythmogenic right ventricular cardiomyopathy', European Heart Journal, bind 36, nr. 27, s. 1735-43. https://doi.org/10.1093/eurheartj/ehv110

Ruwald AC, Marcus F, Estes NAM, Link M, McNitt S, Polonsky B et al. Association of competitive and recreational sport participation with cardiac events in patients with arrhythmogenic right ventricular cardiomyopathy: results from the North American multidisciplinary study of arrhythmogenic right ventricular cardiomyopathy. European Heart Journal. 2015 jul. 14;36(27):1735-43. doi: 10.1093/eurheartj/ehv110

Ruwald, Anne-Christine ; Marcus, Frank ; Estes, N A Mark et al. / Association of competitive and recreational sport participation with cardiac events in patients with arrhythmogenic right ventricular cardiomyopathy : results from the North American multidisciplinary study of arrhythmogenic right ventricular cardiomyopathy. I: European Heart Journal. 2015 ; Bind 36, Nr. 27. s. 1735-43.

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title = "Association of competitive and recreational sport participation with cardiac events in patients with arrhythmogenic right ventricular cardiomyopathy: results from the North American multidisciplinary study of arrhythmogenic right ventricular cardiomyopathy",

abstract = "AIMS: It has been proposed that competitive sport increases the risk of ventricular tachyarrhythmias (VTA) and death in patients with arrhythmogenic right-ventricular cardiomyopathy (ARVC). However, it is unknown whether this only applies to competitive sport or if recreational sports activity also increases the risk of VTA/death.METHODS AND RESULTS: Probands diagnosed with ARVC according to the 2010 task force criteria for ARVC (n = 108) were included in the current analysis. At the time of enrolment, study participants were questioned about exercise level prior to and after ARVC diagnosis, within three categories of sports participation: competitive (n = 41), recreational (n = 48), and inactive (n = 19). Competitive sport was associated with a significantly higher risk of VTA/death when compared with both recreational sport [HR = 1.99 (1.21-3.28), P = 0.007] and inactive patients [HR = 2.05 (1.07-3.91), P = 0.030]. No increased risk of VTA/death was associated with recreational sport when compared with patients who were inactive [HR = 1.03 (0.54-1.97), P = 0.930]. Symptoms developed at an earlier age in patients who participated in competitive sport (30 ± 12 years), when compared with patients who participated in recreational sport (38 ± 17 years) (P = 0.015) and inactive patients (41 ± 11 years) (P = 0.002). No difference in age at first symptom was seen between patients who participated in recreational sport and inactive patients (P = 0.651).CONCLUSION: Competitive sport was associated with a two-fold increased risk of VTA/death, and earlier presentation of symptoms, when compared with inactive patients, and to patients who participated in recreational sport. When compared with inactive patients, recreational sport was not associated with earlier onset of symptoms or increased risk of VTA/death.CLINICAL TRIALSGOV IDENTIFIER: NCT00024505.",

author = "Anne-Christine Ruwald and Frank Marcus and Estes, {N A Mark} and Mark Link and Scott McNitt and Bronislava Polonsky and Hugh Calkins and Towbin, {Jeffrey A} and Moss, {Arthur J} and Wojciech Zareba",

year = "2015",

month = jul,

day = "14",

doi = "10.1093/eurheartj/ehv110",

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T1 - Association of competitive and recreational sport participation with cardiac events in patients with arrhythmogenic right ventricular cardiomyopathy

T2 - results from the North American multidisciplinary study of arrhythmogenic right ventricular cardiomyopathy

AU - Ruwald, Anne-Christine

AU - Marcus, Frank

AU - Estes, N A Mark

AU - Link, Mark

AU - McNitt, Scott

AU - Polonsky, Bronislava

AU - Calkins, Hugh

AU - Towbin, Jeffrey A

AU - Moss, Arthur J

AU - Zareba, Wojciech

PY - 2015/7/14

Y1 - 2015/7/14

N2 - AIMS: It has been proposed that competitive sport increases the risk of ventricular tachyarrhythmias (VTA) and death in patients with arrhythmogenic right-ventricular cardiomyopathy (ARVC). However, it is unknown whether this only applies to competitive sport or if recreational sports activity also increases the risk of VTA/death.METHODS AND RESULTS: Probands diagnosed with ARVC according to the 2010 task force criteria for ARVC (n = 108) were included in the current analysis. At the time of enrolment, study participants were questioned about exercise level prior to and after ARVC diagnosis, within three categories of sports participation: competitive (n = 41), recreational (n = 48), and inactive (n = 19). Competitive sport was associated with a significantly higher risk of VTA/death when compared with both recreational sport [HR = 1.99 (1.21-3.28), P = 0.007] and inactive patients [HR = 2.05 (1.07-3.91), P = 0.030]. No increased risk of VTA/death was associated with recreational sport when compared with patients who were inactive [HR = 1.03 (0.54-1.97), P = 0.930]. Symptoms developed at an earlier age in patients who participated in competitive sport (30 ± 12 years), when compared with patients who participated in recreational sport (38 ± 17 years) (P = 0.015) and inactive patients (41 ± 11 years) (P = 0.002). No difference in age at first symptom was seen between patients who participated in recreational sport and inactive patients (P = 0.651).CONCLUSION: Competitive sport was associated with a two-fold increased risk of VTA/death, and earlier presentation of symptoms, when compared with inactive patients, and to patients who participated in recreational sport. When compared with inactive patients, recreational sport was not associated with earlier onset of symptoms or increased risk of VTA/death.CLINICAL TRIALSGOV IDENTIFIER: NCT00024505.

AB - AIMS: It has been proposed that competitive sport increases the risk of ventricular tachyarrhythmias (VTA) and death in patients with arrhythmogenic right-ventricular cardiomyopathy (ARVC). However, it is unknown whether this only applies to competitive sport or if recreational sports activity also increases the risk of VTA/death.METHODS AND RESULTS: Probands diagnosed with ARVC according to the 2010 task force criteria for ARVC (n = 108) were included in the current analysis. At the time of enrolment, study participants were questioned about exercise level prior to and after ARVC diagnosis, within three categories of sports participation: competitive (n = 41), recreational (n = 48), and inactive (n = 19). Competitive sport was associated with a significantly higher risk of VTA/death when compared with both recreational sport [HR = 1.99 (1.21-3.28), P = 0.007] and inactive patients [HR = 2.05 (1.07-3.91), P = 0.030]. No increased risk of VTA/death was associated with recreational sport when compared with patients who were inactive [HR = 1.03 (0.54-1.97), P = 0.930]. Symptoms developed at an earlier age in patients who participated in competitive sport (30 ± 12 years), when compared with patients who participated in recreational sport (38 ± 17 years) (P = 0.015) and inactive patients (41 ± 11 years) (P = 0.002). No difference in age at first symptom was seen between patients who participated in recreational sport and inactive patients (P = 0.651).CONCLUSION: Competitive sport was associated with a two-fold increased risk of VTA/death, and earlier presentation of symptoms, when compared with inactive patients, and to patients who participated in recreational sport. When compared with inactive patients, recreational sport was not associated with earlier onset of symptoms or increased risk of VTA/death.CLINICAL TRIALSGOV IDENTIFIER: NCT00024505.

U2 - 10.1093/eurheartj/ehv110

DO - 10.1093/eurheartj/ehv110

M3 - Journal article

C2 - 25896080

SN - 0195-668X

VL - 36

SP - 1735

EP - 1743

JO - European Heart Journal

JF - European Heart Journal

IS - 27

ER -