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Association between women's age and stage, morphology, and implantation of the competent blastocyst: a multicenter cohort study

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Borgstrøm, MB, Grøndahl, ML, Klausen, TW, Danielsen, AK, Thomsen, T, Gabrielsen, A, Zedeler, A, Povlsen, BB, Hnida, C, Almind, GJ, Fedder, J, Kirk, J, Hindkjær, J, Lemmen, JG, Petersen, K, Haahr, K, Petersen, MR, Laursen, S, Hansen, TH, Knudsen, UB, Bentin-Ley, U, Larsen, T & Kesmodel, US 2021, 'Association between women's age and stage, morphology, and implantation of the competent blastocyst: a multicenter cohort study', Fertility and Sterility, bind 115, nr. 3, s. 646-654. https://doi.org/10.1016/j.fertnstert.2020.08.1432

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Author

Borgstrøm, Maria Buhl ; Grøndahl, Marie Louise ; Klausen, Tobias Wirenfeldt ; Danielsen, Anne Kjærgaard ; Thomsen, Thordis ; Gabrielsen, Anette ; Zedeler, Anne ; Povlsen, Betina Boel ; Hnida, Christina ; Almind, Gitte Juul ; Fedder, Jens ; Kirk, John ; Hindkjær, Johnny ; Lemmen, Josephine G ; Petersen, Karsten ; Haahr, Katrine ; Petersen, Morten Rønn ; Laursen, Steen ; Hansen, Thomas Høst ; Knudsen, Ulla Breth ; Bentin-Ley, Ursula ; Larsen, Thomas ; Kesmodel, Ulrik Schiøler. / Association between women's age and stage, morphology, and implantation of the competent blastocyst : a multicenter cohort study. I: Fertility and Sterility. 2021 ; Bind 115, Nr. 3. s. 646-654.

Bibtex

@article{a090da49007f4f3e91a7740cf6a1ced5,
title = "Association between women's age and stage, morphology, and implantation of the competent blastocyst: a multicenter cohort study",
abstract = "OBJECTIVE: To study if the age of women undergoing assisted reproductive technology treatment associates with stage, morphology, and implantation of the competent blastocyst.DESIGN: Multicenter historical cohort study based on exposure (age) and outcome data (blastocyst stage and morphology and initial human chorionic gonadotrophin [hCG] rise) from women undergoing single blastocyst transfer resulting in singleton pregnancy/birth.SETTING: Sixteen private and university-based facilities.PATIENT(S): In this study, 7,246 women who, between 2014 and 2018, underwent controlled ovarian stimulation (COS) or frozen-thawed embryo transfer (FET) with a single blastocyst transfer resulting in singleton pregnancy were identified. Linking data to the Danish Medical Birth Registry resulted in a total of 4,842 women with a live birth being included.INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): The competent blastocyst development stage (1-6), inner cell mass (A, B, C), trophectoderm (A, B, C), and initial serum hCG value.RESULT(S): Adjusted analysis of age and stage in COS treatments showed that for every 1-year increase in age there was a 5% reduced probability of the competent blastocyst assessed as being in a high stage at transfer. Comparison between hCG values in women 18-24 years and 25-29 years in both COS and FET showed significantly lower levels in the youngest women.CONCLUSION(S): The initial hCG rise was influenced by the age of the woman, with an identical pattern for hCG values in COS and FET treatments. In COS, the competent blastocyst had a reduced stage with increasing women's age.",
keywords = "competent blastocyst, implantation, morphology, Women's age",
author = "Borgstr{\o}m, {Maria Buhl} and Gr{\o}ndahl, {Marie Louise} and Klausen, {Tobias Wirenfeldt} and Danielsen, {Anne Kj{\ae}rgaard} and Thordis Thomsen and Anette Gabrielsen and Anne Zedeler and Povlsen, {Betina Boel} and Christina Hnida and Almind, {Gitte Juul} and Jens Fedder and John Kirk and Johnny Hindkj{\ae}r and Lemmen, {Josephine G} and Karsten Petersen and Katrine Haahr and Petersen, {Morten R{\o}nn} and Steen Laursen and Hansen, {Thomas H{\o}st} and Knudsen, {Ulla Breth} and Ursula Bentin-Ley and Thomas Larsen and Kesmodel, {Ulrik Schi{\o}ler}",
note = "Copyright {\textcopyright} 2020 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.",
year = "2021",
month = mar,
doi = "10.1016/j.fertnstert.2020.08.1432",
language = "English",
volume = "115",
pages = "646--654",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc",
number = "3",

}

RIS

TY - JOUR

T1 - Association between women's age and stage, morphology, and implantation of the competent blastocyst

T2 - a multicenter cohort study

AU - Borgstrøm, Maria Buhl

AU - Grøndahl, Marie Louise

AU - Klausen, Tobias Wirenfeldt

AU - Danielsen, Anne Kjærgaard

AU - Thomsen, Thordis

AU - Gabrielsen, Anette

AU - Zedeler, Anne

AU - Povlsen, Betina Boel

AU - Hnida, Christina

AU - Almind, Gitte Juul

AU - Fedder, Jens

AU - Kirk, John

AU - Hindkjær, Johnny

AU - Lemmen, Josephine G

AU - Petersen, Karsten

AU - Haahr, Katrine

AU - Petersen, Morten Rønn

AU - Laursen, Steen

AU - Hansen, Thomas Høst

AU - Knudsen, Ulla Breth

AU - Bentin-Ley, Ursula

AU - Larsen, Thomas

AU - Kesmodel, Ulrik Schiøler

N1 - Copyright © 2020 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

PY - 2021/3

Y1 - 2021/3

N2 - OBJECTIVE: To study if the age of women undergoing assisted reproductive technology treatment associates with stage, morphology, and implantation of the competent blastocyst.DESIGN: Multicenter historical cohort study based on exposure (age) and outcome data (blastocyst stage and morphology and initial human chorionic gonadotrophin [hCG] rise) from women undergoing single blastocyst transfer resulting in singleton pregnancy/birth.SETTING: Sixteen private and university-based facilities.PATIENT(S): In this study, 7,246 women who, between 2014 and 2018, underwent controlled ovarian stimulation (COS) or frozen-thawed embryo transfer (FET) with a single blastocyst transfer resulting in singleton pregnancy were identified. Linking data to the Danish Medical Birth Registry resulted in a total of 4,842 women with a live birth being included.INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): The competent blastocyst development stage (1-6), inner cell mass (A, B, C), trophectoderm (A, B, C), and initial serum hCG value.RESULT(S): Adjusted analysis of age and stage in COS treatments showed that for every 1-year increase in age there was a 5% reduced probability of the competent blastocyst assessed as being in a high stage at transfer. Comparison between hCG values in women 18-24 years and 25-29 years in both COS and FET showed significantly lower levels in the youngest women.CONCLUSION(S): The initial hCG rise was influenced by the age of the woman, with an identical pattern for hCG values in COS and FET treatments. In COS, the competent blastocyst had a reduced stage with increasing women's age.

AB - OBJECTIVE: To study if the age of women undergoing assisted reproductive technology treatment associates with stage, morphology, and implantation of the competent blastocyst.DESIGN: Multicenter historical cohort study based on exposure (age) and outcome data (blastocyst stage and morphology and initial human chorionic gonadotrophin [hCG] rise) from women undergoing single blastocyst transfer resulting in singleton pregnancy/birth.SETTING: Sixteen private and university-based facilities.PATIENT(S): In this study, 7,246 women who, between 2014 and 2018, underwent controlled ovarian stimulation (COS) or frozen-thawed embryo transfer (FET) with a single blastocyst transfer resulting in singleton pregnancy were identified. Linking data to the Danish Medical Birth Registry resulted in a total of 4,842 women with a live birth being included.INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): The competent blastocyst development stage (1-6), inner cell mass (A, B, C), trophectoderm (A, B, C), and initial serum hCG value.RESULT(S): Adjusted analysis of age and stage in COS treatments showed that for every 1-year increase in age there was a 5% reduced probability of the competent blastocyst assessed as being in a high stage at transfer. Comparison between hCG values in women 18-24 years and 25-29 years in both COS and FET showed significantly lower levels in the youngest women.CONCLUSION(S): The initial hCG rise was influenced by the age of the woman, with an identical pattern for hCG values in COS and FET treatments. In COS, the competent blastocyst had a reduced stage with increasing women's age.

KW - competent blastocyst

KW - implantation

KW - morphology

KW - Women's age

UR - http://www.scopus.com/inward/record.url?scp=85094867023&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2020.08.1432

DO - 10.1016/j.fertnstert.2020.08.1432

M3 - Journal article

C2 - 33129507

VL - 115

SP - 646

EP - 654

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 3

ER -

ID: 61405922