Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Association between vascular inflammation and inflammation in adipose tissue, spleen, and bone marrow in patients with psoriasis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Awareness, Diagnosis and Management of Idiopathic Intracranial Hypertension

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Outcomes Evaluated in Controlled Clinical Trials on the Management of COVID-19: A Methodological Systematic Review

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Safety of the combined use of methotrexate and acitretin in a dermatology hospital setting

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  2. Characterization of the Oral and Gut Microbiota in Patients with Psoriatic Diseases: A Systematic Review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

Psoriasis is associated with atherosclerotic cardiovascular disease (CVD) with significant overlap of inflammatory pathways. A link between vascular inflammation and inflammation in multiple adipose tissue types, spleen, and bone marrow may exist. Therefore, we investigated these associations using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in patients with psoriasis (n = 83) where half had established CVD. Carotid ultrasound imaging was also performed. Inflammation was measured by FDG uptake in the aorta, visceral- (VAT), subcutaneous- (SAT), and pericardial (PAT) adipose tissues, and spleen and bone marrow, respectively. Vascular inflammation was associated with FDG uptakes in all adipose tissues, including VAT (β = 0.26; p < 0.001), SAT (β = 0.28; p < 0.001), PAT (β = 0.24; p < 0.001), spleen (β = 1.35; p = 0.001), and bone marrow (β = 1.14; p < 0.001). Adjustments for age, sex, body mass index, and high sensitivity C-reactive protein did not change the results. These associations were generally preserved in the patients without prior CVD. No associations were observed between vascular inflammation and carotid intima-media thickness or presence of carotid plaques, respectively. The results suggest an inflammatory link between vascular and adipose tissues, spleen, and bone marrow in patients with psoriasis.

Udgave nummer4
StatusUdgivet - 1 apr. 2021

Bibliografisk note

Funding Information:
Funding: The study is supported by the LEO Foundation (grant no. LF16115).

Funding Information:
Conflicts of Interest: P.R.H. is recipient of a Borregaard clinical scientist fellowship from the NOVO Nordisk Foundation and chairs a clinical academic group supported by the Greater Region of Copenhagen. C.B. is a consultant for Onegevity Health. L.S. has been a paid speaker for AbbVie, Eli Lilly, and LEO Pharma and has been a consultant or served on Advisory Boards with AbbVie, Janssen Cilag, Novartis, Eli Lilly, LEO Pharma, UCB, Admirall, and Sanofi. She has served as an investigator for AbbVie, Janssen Cilag, Boehringer Ingelheim, AstraZenica, Eli Lilly, Novartis, Regeneron, and LEO Pharma and received research and educational grant from Pfizer, AbbVie, Novartis, Sanofi, Janssen Cilag, and Leo Pharma. C.Z. has been scientific consultant, advisor, investigator and speaker for Eli Lilly, Jansen Cilag, Novartis, Abb Vie, Takeda, Amgen, Almirall, CSL, UCB, Regeneron, MSD, and Leo Pharma. H.K., A.K.H., M.K., P.M.G., K.M.A.H., XW declare that they have no competing interests.

Publisher Copyright:
© 2021 by the authors.

Copyright 2021 Elsevier B.V., All rights reserved.

ID: 66081278