Association between ten-eleven methylcytosine dioxygenase 2 genetic variation and viral load in people with HIV

Daniel D Murray*, Birgit Grund, Cameron MacPherson, Christina Ekenberg, Adrian Zucco, Joanne Reekie, Lourdes Dominguez-Dominguez, Preston Leung, Dahlene Fusco, Julien Gras, Jan Gerstoft, Marie Helleberg, Álvaro H Borges, Mark Polizzotto, Jens D Lundgren, INSIGHT START, SMART, ESPRIT, STALWART study groups, the FIRST study group

*Corresponding author af dette arbejde

Abstract

INTRODUCTION: Identifying genetic factors that influence HIV-pathogenesis is critical for understanding disease pathways. Previous studies have suggested a role for the human gene ten-eleven methylcytosine dioxygenase 2 (TET2) in modulating HIV-pathogenesis.

METHODS: We assessed whether genetic variation in TET2 was associated with markers of HIV-pathogenesis using both gene level and single nucleotide polymorphism (SNP) level association in 8512 HIV-positive persons across five clinical trial cohorts.

RESULTS: Variation at both the gene and SNP-level of TET2 was found to be associated with levels of HIV viral load (HIV-VL) consistently in the two cohorts that recruited antiretroviral-naïve participants. The SNPs occurred in two clusters of high linkage disequilibrium (LD), one associated with high HIV-VL and the other low HIV-VL, and were predominantly found in Black participants.

CONCLUSION: Genetic variation in TET2 was associated with HIV-VL in two large antiretroviral therapy (ART)-naive clinical trial cohorts. The role of TET2 in HIV-pathogenesis warrants further investigation.

OriginalsprogEngelsk
TidsskriftAIDS
Vol/bind37
Udgave nummer3
Sider (fra-til)379-387
Antal sider9
ISSN0269-9370
DOI
StatusUdgivet - 1 mar. 2023

Fingeraftryk

Dyk ned i forskningsemnerne om 'Association between ten-eleven methylcytosine dioxygenase 2 genetic variation and viral load in people with HIV'. Sammen danner de et unikt fingeraftryk.

Citationsformater