TY - JOUR
T1 - Association between obstructive coronary disease and diabetic retinopathy
T2 - Cross-sectional study of coronary angiotomography and multimodal retinal imaging
AU - Campos, Andre Chateaubriand
AU - Lima, Eduardo Gomes
AU - Jacobsen, Peter Karl
AU - Arnould, Louis
AU - Lottenberg, Simao
AU - Maia, Renata Martins
AU - Conci, Livia Silva
AU - Minelli, Tomas
AU - Morato, Andrea
AU - Dantas-Jr, Roberto Nery
AU - Nomura, Cesar Higa
AU - Rissoli, Pedro
AU - Pimentel, Sergio Gianotti
AU - Serrano Junior, Carlos Vicente
N1 - Copyright © 2024 Elsevier Inc. All rights reserved.
PY - 2024
Y1 - 2024
N2 - AIMS: To investigate the association between diabetic retinopathy (DR) and coronary artery disease (CAD) using coronary angiotomography (CCTA) and multimodal retinal imaging (MMRI) with ultra-widefield retinography and optical coherence tomography angiography and structural domain.METHODS: Single-center, cross-sectional, single-blind. Patients with diabetes who had undergone CCTA underwent MMRI. Uni and multivariate analysis were used to assess the association between CAD and DR and to identify variables independently associated with DR.RESULTS: We included 171 patients, 87 CAD and 84 non-CAD. Most CAD patients were males (74 % vs 38 %, P < 0.01), insulin users (52 % vs 38 %, p < 0.01) and revascularized (64 %). They had a higher prevalence of DR (48 % vs 22 %, p = 0.01), microaneurysms (25 % vs 13 %, p = 0.04), intraretinal cysts (22 % vs 8 %, p = 0.01) and areas of reduced capillary density (46 % vs 20 %, p < 0.01). CAD patients also had lower mean vascular density (MVD) (15.7 % vs 16.5,%, p = 0.049) and foveal avascular zone (FAZ) circularity (0.64 ± 0.1 vs 0.69 ± 0.1, p = 0.04). There were significant and negative correlations between Duke coronary score and MVD (r = -0.189; p = 0.03) and FAZ circularity (r = -0,206; p = 0.02). CAD, DM duration and insulin use independently associated with DR.CONCLUSIONS: CAD patients had higher prevalence of DR and lower MVD. CAD, DM duration and insulin use were independently associated with DR.
AB - AIMS: To investigate the association between diabetic retinopathy (DR) and coronary artery disease (CAD) using coronary angiotomography (CCTA) and multimodal retinal imaging (MMRI) with ultra-widefield retinography and optical coherence tomography angiography and structural domain.METHODS: Single-center, cross-sectional, single-blind. Patients with diabetes who had undergone CCTA underwent MMRI. Uni and multivariate analysis were used to assess the association between CAD and DR and to identify variables independently associated with DR.RESULTS: We included 171 patients, 87 CAD and 84 non-CAD. Most CAD patients were males (74 % vs 38 %, P < 0.01), insulin users (52 % vs 38 %, p < 0.01) and revascularized (64 %). They had a higher prevalence of DR (48 % vs 22 %, p = 0.01), microaneurysms (25 % vs 13 %, p = 0.04), intraretinal cysts (22 % vs 8 %, p = 0.01) and areas of reduced capillary density (46 % vs 20 %, p < 0.01). CAD patients also had lower mean vascular density (MVD) (15.7 % vs 16.5,%, p = 0.049) and foveal avascular zone (FAZ) circularity (0.64 ± 0.1 vs 0.69 ± 0.1, p = 0.04). There were significant and negative correlations between Duke coronary score and MVD (r = -0.189; p = 0.03) and FAZ circularity (r = -0,206; p = 0.02). CAD, DM duration and insulin use independently associated with DR.CONCLUSIONS: CAD patients had higher prevalence of DR and lower MVD. CAD, DM duration and insulin use were independently associated with DR.
KW - Coronary artery disease (CAD)
KW - Coronary computed tomography angiography
KW - Diabetes mellitus
KW - Diabetic retinopathy
KW - Digital retinal imaging
KW - Microvascular/macrovascular complications
UR - http://www.scopus.com/inward/record.url?scp=85187565670&partnerID=8YFLogxK
U2 - 10.1016/j.jdiacomp.2024.108721
DO - 10.1016/j.jdiacomp.2024.108721
M3 - Journal article
C2 - 38471431
SN - 1056-8727
VL - 38
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
IS - 4
M1 - 108721
ER -