Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Association Between Neurological Disorders and Death by Suicide in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Continuing Antipsychotic Medication for Patients With Psychotic Depression in Remission

    Publikation: Bidrag til tidsskriftKommentar/debatForskning

  3. Association of Office and Ambulatory Blood Pressure With Mortality and Cardiovascular Outcomes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Treat-to-Target Strategies in Rheumatoid Arthritis-Reply

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  • Simon P Mooijaart
  • Robert S Du Puy
  • David J Stott
  • Patricia M Kearney
  • Nicolas Rodondi
  • Rudi G J Westendorp
  • Wendy P J den Elzen
  • Iris Postmus
  • Rosalinde K E Poortvliet
  • Diana van Heemst
  • Barbara C van Munster
  • Robin P Peeters
  • Ian Ford
  • Sharon Kean
  • Claudia-Martina Messow
  • Manuel R Blum
  • Tinh-Hai Collet
  • Torquil Watt
  • Olaf M Dekkers
  • J Wouter Jukema
  • Johannes W A Smit
  • Peter Langhorne
  • Jacobijn Gussekloo
Vis graf over relationer

Importance: It is unclear whether levothyroxine treatment provides clinically important benefits in adults aged 80 years and older with subclinical hypothyroidism.

Objective: To determine the association of levothyroxine treatment for subclinical hypothyroidism with thyroid-related quality of life in adults aged 80 years and older.

Design, Setting, and Participants: Prospectively planned combined analysis of data involving community-dwelling adults aged 80 years and older with subclinical hypothyroidism. Data from a randomized clinical trial were combined with a subgroup of participants aged 80 years and older from a second clinical trial. The trials were conducted between April 2013 and May 2018. Final follow-up was May 4, 2018.

Exposures: Participants were randomly assigned to receive levothyroxine (n = 112; 52 participants from the first trial and 60 from the second trial) or placebo (n = 139; 53 participants from the first trial and 86 from the second trial).

Main Outcomes and Measures: Co-primary outcomes were Thyroid-Related Quality of Life Patient-Reported Outcome (ThyPRO) questionnaire scores for the domains of hypothyroid symptoms and tiredness at 1 year (range, 0-100; higher scores indicate worse quality of life; minimal clinically important difference, 9).

Results: Of 251 participants (mean age, 85 years; 118 [47%] women), 105 were included from the first clinical trial and 146 were included from the second clinical trial. A total of 212 participants (84%) completed the study. The hypothyroid symptoms score decreased from 21.7 at baseline to 19.3 at 12 months in the levothyroxine group vs from 19.8 at baseline to 17.4 at 12 months in the placebo group (adjusted between-group difference, 1.3 [95% CI, -2.7 to 5.2]; P = .53). The tiredness score increased from 25.5 at baseline to 28.2 at 12 months in the levothyroxine group vs from 25.1 at baseline to 28.7 at 12 months in the placebo group (adjusted between-group difference, -0.1 [95% CI, -4.5 to 4.3]; P = .96). At least 1 adverse event occurred in 33 participants (29.5%) in the levothyroxine group (the most common adverse event was cerebrovascular accident, which occurred in 3 participants [2.2%]) and 40 participants (28.8%) in the placebo group (the most common adverse event was pneumonia, which occurred in 4 [3.6%] participants).

Conclusions and Relevance: In this prospectively planned analysis of data from 2 clinical trials involving adults aged 80 years and older with subclinical hypothyroidism, treatment with levothyroxine, compared with placebo, was not significantly associated with improvement in hypothyroid symptoms or fatigue. These findings do not support routine use of levothyroxine for treatment of subclinical hypothyroidism in adults aged 80 years and older.

Trial Registration: ClinicalTrials.gov Identifier: NCT01660126; Netherlands Trial Register: NTR3851.

OriginalsprogEngelsk
TidsskriftJAMA - Journal of the American Medical Association
ISSN0002-9955
DOI
StatusE-pub ahead of print - 2020

ID: 59233562