Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Association between layer-specific global longitudinal strain and adverse outcomes following acute coronary syndrome

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Prognostic value of ratio of transmitral early filling velocity to early diastolic strain rate in patients with Type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Utility of left atrial strain for predicting atrial fibrillation following ischemic stroke

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Epicardial adipose tissue predicts incident cardiovascular disease and mortality in patients with type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Cardiac function assessed by myocardial deformation in adult polycystic kidney disease patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. An echocardiographic substrate for dyspnea identifies high risk patients with type 2 diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Aims: To investigate the prognostic value of layer-specific global longitudinal strain (GLS) in predicting heart failure (HF) and cardiovascular death (CD) following acute coronary syndrome (ACS).

Methods and results: In this retrospective study, 465 ACS patients underwent transthoracic echocardiography following percutaneous coronary intervention (PCI). The primary endpoint was the composite of HF and/or CD with a median follow-up time of 4.6 (0.2-6.3) years. During follow-up 199 patients (42.7%) suffered HF and/or CD (176 developed HF and 38 suffered CD). Absolute endomyocardial global longitudinal strain (GLSendo) (12% vs. 17%, P < 0.001), GLS (11% vs. 14%, P < 0.001), and epimyocardial global longitudinal strain (GLSepi) (9% vs. 13%, P < 0.001) were all reduced in patients with an adverse outcome. In multivariable Cox regressions, which included clinical baseline characteristics and conventional echocardiographic measurements, GLS obtained from all layers remained independently associated with the composite outcome; GLSendo [hazard ratio: 1.19 (1.10-1.28), P < 0.001, per 1% decrease], GLS [hazard ratio 1.24 (1.14-1.35), P < 0.001, per 1% decrease], and GLSepi [hazard ratio 1.26 (1.15-1.39), P < 0.001, per 1% decrease]. No other echocardiographic measures remained independently associated with the composite outcome in these models. Finally, GLS and GLSepi provided incremental prognostic information on the risk of developing the composite endpoint, when added to all other clinical and echocardiographic measures [adding GLS (c-statistics: 0.76 vs. 0.74, P = 0.048) or adding GLSepi (c-statistics: 0.76 vs. 0.74, P = 0.039)].

Conclusion: In ACS patients, layer-specific strain provides independent prognostic information regarding risk of developing HF and/or CD. Furthermore, only GLS and GLSepi provided incremental prognostic information when added to all other significant predictors.

OriginalsprogEngelsk
TidsskriftEuropean heart journal cardiovascular Imaging
Vol/bind19
Udgave nummer12
Sider (fra-til)1334-1342
Antal sider9
ISSN1525-2167
DOI
StatusUdgivet - 1 dec. 2018

ID: 56147143