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Association between Gestational Weight Gain, Gestational Diabetes Risk, and Obstetric Outcomes: A Randomized Controlled Trial Post Hoc Analysis

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Harvard

Simmons, D, Devlieger, R, van Assche, A, Galjaard, S, Corcoy, R, Adelantado, JM, Dunne, F, Desoye, G, Kautzky-Willer, A, Damm, P, Mathiesen, ER, Jensen, DM, Andersen, LLT, Lapolla, A, Dalfra, MG, Bertolotto, A, Wender-Ozegowska, E, Zawiejska, A, Hill, D, Snoek, FJ & van Poppel, MNM 2018, 'Association between Gestational Weight Gain, Gestational Diabetes Risk, and Obstetric Outcomes: A Randomized Controlled Trial Post Hoc Analysis' Nutrients, bind 10, nr. 11, s. 1568. https://doi.org/10.3390/nu10111568

APA

Simmons, D., Devlieger, R., van Assche, A., Galjaard, S., Corcoy, R., Adelantado, J. M., ... van Poppel, M. N. M. (2018). Association between Gestational Weight Gain, Gestational Diabetes Risk, and Obstetric Outcomes: A Randomized Controlled Trial Post Hoc Analysis. Nutrients, 10(11), 1568. https://doi.org/10.3390/nu10111568

CBE

Simmons D, Devlieger R, van Assche A, Galjaard S, Corcoy R, Adelantado JM, Dunne F, Desoye G, Kautzky-Willer A, Damm P, Mathiesen ER, Jensen DM, Andersen LLT, Lapolla A, Dalfra MG, Bertolotto A, Wender-Ozegowska E, Zawiejska A, Hill D, Snoek FJ, van Poppel MNM. 2018. Association between Gestational Weight Gain, Gestational Diabetes Risk, and Obstetric Outcomes: A Randomized Controlled Trial Post Hoc Analysis. Nutrients. 10(11):1568. https://doi.org/10.3390/nu10111568

MLA

Vancouver

Author

Simmons, David ; Devlieger, Roland ; van Assche, Andre ; Galjaard, Sander ; Corcoy, Rosa ; Adelantado, Juan M ; Dunne, Fidelma ; Desoye, Gernot ; Kautzky-Willer, Alexandra ; Damm, Peter ; Mathiesen, Elisabeth R ; Jensen, Dorte M ; Andersen, Lise Lotte T ; Lapolla, Annunziata ; Dalfra, Maria G ; Bertolotto, Alessandra ; Wender-Ozegowska, Ewa ; Zawiejska, Agnieszka ; Hill, David ; Snoek, Frank J ; van Poppel, Mireille N M. / Association between Gestational Weight Gain, Gestational Diabetes Risk, and Obstetric Outcomes : A Randomized Controlled Trial Post Hoc Analysis. I: Nutrients. 2018 ; Bind 10, Nr. 11. s. 1568.

Bibtex

@article{0aec70409dbd4a0db08f803b91cf1a60,
title = "Association between Gestational Weight Gain, Gestational Diabetes Risk, and Obstetric Outcomes: A Randomized Controlled Trial Post Hoc Analysis",
abstract = "Excess gestational weight gain (GWG) is associated with the development of gestational diabetes mellitus (GDM). Lifestyle trials have not achieved much GWG limitation, and have largely failed to prevent GDM. We compared the effect of substantial GWG limitation on maternal GDM risk. Pregnant women with a body mass index (BMI) ≥29 kg/m² <20 weeks gestation without GDM (n = 436) were randomized, in a multicenter trial, to usual care (UC), healthy eating (HE), physical activity (PA), or HE and PA lifestyle interventions. GWG over the median was associated with higher homeostasis model assessment insulin resistance (HOMA-IR) and insulin secretion (Stumvoll phases 1 and 2), a higher fasting plasma glucose (FPG) at 24⁻28 weeks (4.66 ± 0.43 vs. 4.61 ± 0.40 mmol/L, p < 0.01), and a higher rate of caesarean section (38{\%} vs. 27{\%} p < 0.05). The GWG over the median at 35⁻37 weeks was associated with a higher rate of macrosomia (25{\%} vs. 16{\%}, p < 0.05). A post hoc comparison among women from the five sites with a GWG difference >3 kg showed no significance difference in glycaemia or insulin resistance between HE and PA, and UC. We conclude that preventing even substantial increases in GWG after the first trimester has little effect on maternal glycaemia. We recommend randomized controlled trials of effective lifestyle interventions, starting in or before the first trimester.",
author = "David Simmons and Roland Devlieger and {van Assche}, Andre and Sander Galjaard and Rosa Corcoy and Adelantado, {Juan M} and Fidelma Dunne and Gernot Desoye and Alexandra Kautzky-Willer and Peter Damm and Mathiesen, {Elisabeth R} and Jensen, {Dorte M} and Andersen, {Lise Lotte T} and Annunziata Lapolla and Dalfra, {Maria G} and Alessandra Bertolotto and Ewa Wender-Ozegowska and Agnieszka Zawiejska and David Hill and Snoek, {Frank J} and {van Poppel}, {Mireille N M}",
year = "2018",
month = "10",
day = "23",
doi = "10.3390/nu10111568",
language = "English",
volume = "10",
pages = "1568",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "11",

}

RIS

TY - JOUR

T1 - Association between Gestational Weight Gain, Gestational Diabetes Risk, and Obstetric Outcomes

T2 - A Randomized Controlled Trial Post Hoc Analysis

AU - Simmons, David

AU - Devlieger, Roland

AU - van Assche, Andre

AU - Galjaard, Sander

AU - Corcoy, Rosa

AU - Adelantado, Juan M

AU - Dunne, Fidelma

AU - Desoye, Gernot

AU - Kautzky-Willer, Alexandra

AU - Damm, Peter

AU - Mathiesen, Elisabeth R

AU - Jensen, Dorte M

AU - Andersen, Lise Lotte T

AU - Lapolla, Annunziata

AU - Dalfra, Maria G

AU - Bertolotto, Alessandra

AU - Wender-Ozegowska, Ewa

AU - Zawiejska, Agnieszka

AU - Hill, David

AU - Snoek, Frank J

AU - van Poppel, Mireille N M

PY - 2018/10/23

Y1 - 2018/10/23

N2 - Excess gestational weight gain (GWG) is associated with the development of gestational diabetes mellitus (GDM). Lifestyle trials have not achieved much GWG limitation, and have largely failed to prevent GDM. We compared the effect of substantial GWG limitation on maternal GDM risk. Pregnant women with a body mass index (BMI) ≥29 kg/m² <20 weeks gestation without GDM (n = 436) were randomized, in a multicenter trial, to usual care (UC), healthy eating (HE), physical activity (PA), or HE and PA lifestyle interventions. GWG over the median was associated with higher homeostasis model assessment insulin resistance (HOMA-IR) and insulin secretion (Stumvoll phases 1 and 2), a higher fasting plasma glucose (FPG) at 24⁻28 weeks (4.66 ± 0.43 vs. 4.61 ± 0.40 mmol/L, p < 0.01), and a higher rate of caesarean section (38% vs. 27% p < 0.05). The GWG over the median at 35⁻37 weeks was associated with a higher rate of macrosomia (25% vs. 16%, p < 0.05). A post hoc comparison among women from the five sites with a GWG difference >3 kg showed no significance difference in glycaemia or insulin resistance between HE and PA, and UC. We conclude that preventing even substantial increases in GWG after the first trimester has little effect on maternal glycaemia. We recommend randomized controlled trials of effective lifestyle interventions, starting in or before the first trimester.

AB - Excess gestational weight gain (GWG) is associated with the development of gestational diabetes mellitus (GDM). Lifestyle trials have not achieved much GWG limitation, and have largely failed to prevent GDM. We compared the effect of substantial GWG limitation on maternal GDM risk. Pregnant women with a body mass index (BMI) ≥29 kg/m² <20 weeks gestation without GDM (n = 436) were randomized, in a multicenter trial, to usual care (UC), healthy eating (HE), physical activity (PA), or HE and PA lifestyle interventions. GWG over the median was associated with higher homeostasis model assessment insulin resistance (HOMA-IR) and insulin secretion (Stumvoll phases 1 and 2), a higher fasting plasma glucose (FPG) at 24⁻28 weeks (4.66 ± 0.43 vs. 4.61 ± 0.40 mmol/L, p < 0.01), and a higher rate of caesarean section (38% vs. 27% p < 0.05). The GWG over the median at 35⁻37 weeks was associated with a higher rate of macrosomia (25% vs. 16%, p < 0.05). A post hoc comparison among women from the five sites with a GWG difference >3 kg showed no significance difference in glycaemia or insulin resistance between HE and PA, and UC. We conclude that preventing even substantial increases in GWG after the first trimester has little effect on maternal glycaemia. We recommend randomized controlled trials of effective lifestyle interventions, starting in or before the first trimester.

U2 - 10.3390/nu10111568

DO - 10.3390/nu10111568

M3 - Journal article

VL - 10

SP - 1568

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 11

ER -

ID: 56081446