Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Association between genes on chromosome 19p13.2 and panic disorder

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Are TMEM genes potential candidate genes for panic disorder?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. An association study between the norepinephrine transporter gene and depression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Neuropeptide Y genes and suicidal behaviour among schizophrenic patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Sequence analysis of SLITRK1 for var321 in Danish patients with Tourette syndrome and review of the literature

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. A pilot study on high amplitude low frequency-music impulse stimulation as an add-on treatment for depression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Selvmordsforebyggelse – hvordan kommer vi videre?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Whole-exome sequencing of individuals from an isolated population implicates rare risk variants in bipolar disorder

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Noomi O Gregersen
  • Henriette N Buttenschøn
  • Anne Hedemand
  • Marit N Nielsen
  • Hans A Dahl
  • Ann S Kristensen
  • Oddbjørg Johansen
  • David P D Woldbye
  • Angelika Erhardt
  • Torben A Kruse
  • August G Wang
  • Anders D Børglum
  • Ole Mors
Vis graf over relationer

Panic disorder (PD) is a severe and disabling mental disorder, which is moderately heritable. In a previous study, we carried out a genome-wide association study using patients with PD and control individuals from the isolated population of the Faroe Islands and identified chromosome 19p13.2 as a candidate region. To further investigate this chromosomal region for association with PD, we analysed eight single nucleotide polymorphisms (SNPs) in three candidate genes - small-nuclear RNA activating complex, polypeptide 2 (SNAPC2), mitogen-activated protein kinase kinase 7 (MAP2K7) and leucine-rich repeat containing 8 family, member E (LRRC8E) - these genes have previously been directly or indirectly implicated in other mental disorders. A total of 511 patients with PD and 1029 healthy control individuals from the Faroe Islands, Denmark and Germany were included in the current study. SNPs covering the gene region of SNAPC2, MAP2K7 and LRRC8E were genotyped and tested for association with PD. In the Faroese cohort, rs7788 within SNAPC2 was significantly associated with PD, whereas rs3745383 within LRRC8E was nominally associated. No association was observed between the analysed SNPs and PD in the Danish cohorts. In the German women, we observed a nominal association between rs4804833 within MAP2K7 and PD. We present further evidence that chromosome 19p13.2 may harbour candidate genes that contribute towards the risk of developing PD. Moreover, the implication of the associated genes in other mental disorders may indicate shared genetic susceptibility between mental disorders. We show that associated variants may be sex specific, indicating the importance of carrying out a sex-specific association analysis of PD.

OriginalsprogEngelsk
TidsskriftPsychiatric Genetics
Vol/bind26
Udgave nummer6
Sider (fra-til)287-292
ISSN0955-8829
DOI
StatusUdgivet - dec. 2016

ID: 49262218