Association between DPP6 polymorphism and the risk of progressive multiple sclerosis in Northern and Southern Europeans

Paola Brambilla, Federica Esposito, Eva Lindstrom, Melissa Sorosina, Giacomo Giacalone, Ferdinando Clarelli, Mariaemma Rodegher, Bruno Colombo, Lucia Moiola, Angelo Ghezzi, Ruggero Capra, Laura Collimedaglia, Gabriella Coniglio, Elisabeth G Celius, Daniela Galimberti, Per Soelberg Sørensen, Vittorio Martinelli, Annette B Oturai, Hanne F Harbo, Jan HillertGiancarlo Comi, Filippo Martinelli-Boneschi

16 Citationer (Scopus)

Abstract

In this study, we investigated the role of the dipeptidyl-peptidase-6 (DPP6) gene in the etiopathogenesis of progressive forms of multiple sclerosis (PrMS). This gene emerged as a candidate gene in a genome-wide association study (GWAS) performed in an Italian sample of PrMS and controls in which two SNPs located in the gene (rs6956703 and rs11767658) showed evidence of association (nominal p-value
OriginalsprogEngelsk
TidsskriftNeuroscience Letters
Vol/bind530
Udgave nummer2
Sider (fra-til)155-60
Antal sider6
ISSN0304-3940
DOI
StatusUdgivet - 2012

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