TY - JOUR
T1 - Association Between Common Cardiovascular Risk Factors and Clinical Phenotype in Patients with Hypertrophic Cardiomyopathy From the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis Registry
AU - Lopes, Luis R
AU - Losi, Maria-Angela
AU - Sheikh, Nabeel
AU - Laroche, Cécile
AU - Charron, Philippe
AU - Gimeno, Juan
AU - Kaski, Juan P
AU - Maggioni, Aldo P
AU - Tavazzi, Luigi
AU - Arbustini, Eloisa
AU - Brito, Dulce
AU - Celutkiene, Jelena
AU - Hagege, Albert
AU - Linhart, Ales
AU - Mogensen, Jens
AU - Garcia-Pinilla, José Manuel
AU - Ripoll-Vera, Tomas
AU - Seggewiss, Hubert
AU - Villacorta, Eduardo
AU - Caforio, Alida
AU - Elliott, Perry M
AU - Cardiomyopathy Registry Investigators Group
A2 - Tfelt-Hansen, Jacob
A2 - Bundgaard, Henning
A2 - Thune, Jens Jakob
A2 - Axelsson, Anna
N1 - © The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.
PY - 2022/12/13
Y1 - 2022/12/13
N2 - AIMS: The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry.METHODS AND RESULTS: 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI), and clinical traits was analysed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene. The prevalence of HT, DM, and obesity (Ob) was 37, 10, and 21%, respectively. HT, DM, and Ob were associated with older age (P<0.001), less family history of HCM (HT and DM P<0.001), higher New York Heart Association (NYHA) class (P<0.001), atrial fibrillation (HT and DM P<0.001; Ob p = 0.03) and LV (left ventricular) diastolic dysfunction (HT and Ob P<0.001; DM P = 0.003). Stroke was more frequent in HT (P<0.001) and mutation-positive patients with DM (P = 0.02). HT and Ob were associated with higher provocable LV outflow tract gradients (HT P<0.001, Ob P = 0.036). LV hypertrophy was more severe in Ob (P = 0.018). HT and Ob were independently associated with NYHA class (OR 1.419, P = 0.017 and OR 1.584, P = 0.004, respectively). Other associations, including a higher proportion of females in HT and of systolic dysfunction in HT and Ob, were observed only in mutation-positive patients.CONCLUSION: Common CVRF are associated with a more severe HCM phenotype, suggesting a proactive management of CVRF should be promoted. An interaction between genotype and CVRF was observed for some traits.
AB - AIMS: The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry.METHODS AND RESULTS: 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI), and clinical traits was analysed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene. The prevalence of HT, DM, and obesity (Ob) was 37, 10, and 21%, respectively. HT, DM, and Ob were associated with older age (P<0.001), less family history of HCM (HT and DM P<0.001), higher New York Heart Association (NYHA) class (P<0.001), atrial fibrillation (HT and DM P<0.001; Ob p = 0.03) and LV (left ventricular) diastolic dysfunction (HT and Ob P<0.001; DM P = 0.003). Stroke was more frequent in HT (P<0.001) and mutation-positive patients with DM (P = 0.02). HT and Ob were associated with higher provocable LV outflow tract gradients (HT P<0.001, Ob P = 0.036). LV hypertrophy was more severe in Ob (P = 0.018). HT and Ob were independently associated with NYHA class (OR 1.419, P = 0.017 and OR 1.584, P = 0.004, respectively). Other associations, including a higher proportion of females in HT and of systolic dysfunction in HT and Ob, were observed only in mutation-positive patients.CONCLUSION: Common CVRF are associated with a more severe HCM phenotype, suggesting a proactive management of CVRF should be promoted. An interaction between genotype and CVRF was observed for some traits.
KW - Cardiomyopathies/complications
KW - Cardiomyopathy, Hypertrophic/complications
KW - Cardiovascular Diseases/epidemiology
KW - Female
KW - Heart Disease Risk Factors
KW - Humans
KW - Hypertension/complications
KW - Obesity/complications
KW - Risk Factors
KW - Ventricular Dysfunction, Left/complications
KW - Hypertension
KW - Obesity
KW - Genotype
KW - Cardiovascular risk factors
KW - Hypertrophic cardiomyopathy
KW - Diabetes
UR - http://www.scopus.com/inward/record.url?scp=85136423278&partnerID=8YFLogxK
U2 - 10.1093/ehjqcco/qcac006
DO - 10.1093/ehjqcco/qcac006
M3 - Journal article
C2 - 35138368
VL - 9
SP - 42
EP - 53
JO - European heart journal. Quality of care & clinical outcomes
JF - European heart journal. Quality of care & clinical outcomes
SN - 2058-5225
IS - 1
ER -