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Udgivet

Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex human exposures

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  1. Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Cumulative risk assessment of phthalate exposure of Danish children and adolescents using the hazard index approach

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Early breast development in girls after prenatal exposure to non-persistent pesticides

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  4. Goodbye International Journal of Andrology, welcome Andrology!

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  1. Endocrine Disrupting Chemicals and Risk of Testicular Cancer: A Systematic Review and Meta-analysis

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Brain tumours in children and adolescents may affect the circadian rhythm and quality of life

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Brain tumours result in sleep disorders in children and adolescents

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Paracetamol use during pregnancy - a call for precautionary action

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  • Konrad Krysiak-Baltyn
  • J Toppari
  • N E Skakkebaek
  • T S Jensen
  • H E Virtanen
  • K-W Schramm
  • Hao Shen
  • T Vartiainen
  • H Kiviranta
  • Olivier Taboureau
  • Karine Marie Laure Audouze
  • Søren Brunak
  • K M Main
Vis graf over relationer
During the past four decades, there has been an increase in the incidence rate of male reproductive disorders in some, but not all, Western countries. The observed increase in the prevalence of male reproductive disorders is suspected to be ascribable to environmental factors as the increase has been too rapid to be explained by genetics alone. To study the association between complex chemical exposures of humans and congenital cryptorchidism, the most common malformation of the male genitalia, we measured 121 environmental chemicals with suspected or known endocrine disrupting properties in 130 breast milk samples from Danish and Finnish mothers. Half the newborns were healthy controls, whereas the other half was boys with congenital cryptorchidism. The measured chemicals included polychlorinated biphenyls (PCBs), polybrominated diphenyl-ethers, dioxins (OCDD/PCDFs), phthalates, polybrominated biphenyls and organochlorine pesticides. Computational analysis of the data was performed using logistic regression and three multivariate machine learning classifiers. Furthermore, we performed systems biology analysis to explore the chemical influence on a molecular level. After correction for multiple testing, exposure to nine chemicals was significantly different between the cases and controls in the Danish cohort, but not in the Finnish cohort. The multivariate analysis indicated that Danish samples exhibited a stronger correlation between chemical exposure patterns in breast milk and cryptorchidism than Finnish samples. Moreover, PCBs were indicated as having a protective effect within the Danish cohort, which was supported by molecular data recovered through systems biology. Our results lend further support to the hypothesis that the mixture of environmental chemicals may contribute to observed adverse trends in male reproductive health.
OriginalsprogEngelsk
TidsskriftInternational Journal of Andrology
Vol/bind35
Udgave nummer3
Sider (fra-til)294-302
Antal sider9
ISSN0105-6263
DOI
StatusUdgivet - 2012

ID: 36808426