Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer

Kelly L Bolton; Georgia Chenevix-Trench; Cindy Goh; Siegal Sadetzki; Susan J Ramus; Beth Y Karlan; Diether Lambrechts; Evelyn Despierre; Daniel Barrowdale; Lesley McGuffog; Sue Healey; Douglas F Easton; Olga Sinilnikova; Javier Benítez; María J García; Susan Neuhausen; Mitchell H Gail; Patricia Hartge; Susan Peock; Debra Frost; D Gareth Evans; Rosalind Eeles; Andrew K Godwin; Mary B Daly; Ava Kwong; Edmond S K Ma; Conxi Lázaro; Ignacio Blanco; Marco Montagna; Emma D'Andrea; Maria Ornella Nicoletto; Sharon E Johnatty; Susanne Krüger Kjær; Allan Jensen; Estrid Høgdall; Ellen L Goode; Brooke L Fridley; Jennifer T Loud; Mark H Greene; Phuong L Mai; Angela Chetrit; Flora Lubin; Galit Hirsh-Yechezkel; Gord Glendon; Irene L Andrulis; Amanda E Toland; Leigha Senter; Martin E Gore; Charlie Gourley; Caroline O Michie; EMBRACE

doi:10.1001/jama.2012.20

Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer

Kelly L Bolton
, Georgia Chenevix-Trench
, Cindy Goh
, Siegal Sadetzki
, Susan J Ramus
, Beth Y Karlan
, Diether Lambrechts
, Evelyn Despierre
, Daniel Barrowdale
, Lesley McGuffog
, Sue Healey
, Douglas F Easton
, Olga Sinilnikova
, Javier Benítez
, María J García
, Susan Neuhausen
, Mitchell H Gail
, Patricia Hartge
, Susan Peock
, Debra Frost

D Gareth Evans, Rosalind Eeles, Andrew K Godwin, Mary B Daly, Ava Kwong, Edmond S K Ma, Conxi Lázaro, Ignacio Blanco, Marco Montagna, Emma D'Andrea, Maria Ornella Nicoletto, Sharon E Johnatty, Susanne Krüger Kjær, Allan Jensen, Estrid Høgdall, Ellen L Goode, Brooke L Fridley, Jennifer T Loud, Mark H Greene, Phuong L Mai, Angela Chetrit, Flora Lubin, Galit Hirsh-Yechezkel, Gord Glendon, Irene L Andrulis, Amanda E Toland, Leigha Senter, Martin E Gore, Charlie Gourley, Caroline O Michie, EMBRACE

Patologiafdeling

601 Citationer (Scopus)

Abstract

Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear.

Originalsprog	Engelsk
Tidsskrift	J A M A: The Journal of the American Medical Association
Vol/bind	307
Udgave nummer	4
Sider (fra-til)	382-90
Antal sider	9
ISSN	0098-7484
DOI	https://doi.org/10.1001/jama.2012.20
Status	Udgivet - 2012

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10.1001/jama.2012.20

Citationsformater

Bolton, K. L., Chenevix-Trench, G., Goh, C., Sadetzki, S., Ramus, S. J., Karlan, B. Y., Lambrechts, D., Despierre, E., Barrowdale, D., McGuffog, L., Healey, S., Easton, D. F., Sinilnikova, O., Benítez, J., García, M. J., Neuhausen, S., Gail, M. H., Hartge, P., Peock, S., ... EMBRACE (2012). Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. J A M A: The Journal of the American Medical Association, 307(4), 382-90. https://doi.org/10.1001/jama.2012.20

Bolton, KL, Chenevix-Trench, G, Goh, C, Sadetzki, S, Ramus, SJ, Karlan, BY, Lambrechts, D, Despierre, E, Barrowdale, D, McGuffog, L, Healey, S, Easton, DF, Sinilnikova, O, Benítez, J, García, MJ, Neuhausen, S, Gail, MH, Hartge, P, Peock, S, Frost, D, Evans, DG, Eeles, R, Godwin, AK, Daly, MB, Kwong, A, Ma, ESK, Lázaro, C, Blanco, I, Montagna, M, D'Andrea, E, Nicoletto, MO, Johnatty, SE, Kjær, SK, Jensen, A, Høgdall, E, Goode, EL, Fridley, BL, Loud, JT, Greene, MH, Mai, PL, Chetrit, A, Lubin, F, Hirsh-Yechezkel, G, Glendon, G, Andrulis, IL, Toland, AE, Senter, L, Gore, ME, Gourley, C, Michie, CO & EMBRACE 2012, 'Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer', J A M A: The Journal of the American Medical Association, bind 307, nr. 4, s. 382-90. https://doi.org/10.1001/jama.2012.20

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title = "Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer",

abstract = "Approximately 10\% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear.",

keywords = "Adult, Aged, Female, Genes, BRCA1, Genes, BRCA2, Germ-Line Mutation, Humans, Middle Aged, Ovarian Neoplasms, Prognosis, Survival Analysis",

author = "Bolton, \{Kelly L\} and Georgia Chenevix-Trench and Cindy Goh and Siegal Sadetzki and Ramus, \{Susan J\} and Karlan, \{Beth Y\} and Diether Lambrechts and Evelyn Despierre and Daniel Barrowdale and Lesley McGuffog and Sue Healey and Easton, \{Douglas F\} and Olga Sinilnikova and Javier Ben{\'i}tez and Garc{\'i}a, \{Mar{\'i}a J\} and Susan Neuhausen and Gail, \{Mitchell H\} and Patricia Hartge and Susan Peock and Debra Frost and Evans, \{D Gareth\} and Rosalind Eeles and Godwin, \{Andrew K\} and Daly, \{Mary B\} and Ava Kwong and Ma, \{Edmond S K\} and Conxi L{\'a}zaro and Ignacio Blanco and Marco Montagna and Emma D'Andrea and Nicoletto, \{Maria Ornella\} and Johnatty, \{Sharon E\} and Kj{\ae}r, \{Susanne Kr{\"u}ger\} and Allan Jensen and Estrid H{\o}gdall and Goode, \{Ellen L\} and Fridley, \{Brooke L\} and Loud, \{Jennifer T\} and Greene, \{Mark H\} and Mai, \{Phuong L\} and Angela Chetrit and Flora Lubin and Galit Hirsh-Yechezkel and Gord Glendon and Andrulis, \{Irene L\} and Toland, \{Amanda E\} and Leigha Senter and Gore, \{Martin E\} and Charlie Gourley and Michie, \{Caroline O\} and EMBRACE",

year = "2012",

doi = "10.1001/jama.2012.20",

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pages = "382--90",

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AU - Bolton, Kelly L

AU - Chenevix-Trench, Georgia

AU - Goh, Cindy

AU - Sadetzki, Siegal

AU - Ramus, Susan J

AU - Karlan, Beth Y

AU - Lambrechts, Diether

AU - Despierre, Evelyn

AU - Barrowdale, Daniel

AU - McGuffog, Lesley

AU - Healey, Sue

AU - Easton, Douglas F

AU - Sinilnikova, Olga

AU - Benítez, Javier

AU - García, María J

AU - Neuhausen, Susan

AU - Gail, Mitchell H

AU - Hartge, Patricia

AU - Peock, Susan

AU - Frost, Debra

AU - Evans, D Gareth

AU - Eeles, Rosalind

AU - Godwin, Andrew K

AU - Daly, Mary B

AU - Kwong, Ava

AU - Ma, Edmond S K

AU - Lázaro, Conxi

AU - Blanco, Ignacio

AU - Montagna, Marco

AU - D'Andrea, Emma

AU - Nicoletto, Maria Ornella

AU - Johnatty, Sharon E

AU - Kjær, Susanne Krüger

AU - Jensen, Allan

AU - Høgdall, Estrid

AU - Goode, Ellen L

AU - Fridley, Brooke L

AU - Loud, Jennifer T

AU - Greene, Mark H

AU - Mai, Phuong L

AU - Chetrit, Angela

AU - Lubin, Flora

AU - Hirsh-Yechezkel, Galit

AU - Glendon, Gord

AU - Andrulis, Irene L

AU - Toland, Amanda E

AU - Senter, Leigha

AU - Gore, Martin E

AU - Gourley, Charlie

AU - Michie, Caroline O

AU - EMBRACE

PY - 2012

Y1 - 2012

N2 - Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear.

AB - Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was associated with an improved prognosis, but the effect of BRCA1 remains unclear.

KW - Adult

KW - Aged

KW - Female

KW - Genes, BRCA1

KW - Genes, BRCA2

KW - Germ-Line Mutation

KW - Humans

KW - Middle Aged

KW - Ovarian Neoplasms

KW - Prognosis

KW - Survival Analysis

U2 - 10.1001/jama.2012.20

DO - 10.1001/jama.2012.20

M3 - Journal article

C2 - 22274685

SN - 0098-7484

VL - 307

SP - 382

EP - 390

JO - J A M A: The Journal of the American Medical Association

JF - J A M A: The Journal of the American Medical Association

IS - 4

ER -

Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer

Abstract

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