Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

A Kaas; Claudia Christina Pfleger; A V Kharagjitsingh; N C Schloot; Lars  Hansen; K Buschard; B P C Koeleman; B O Roep; H B Mortensen; B Z Alizadeh; on behalf of the Hvidoere Study Group on Childhood Diabetes

doi:10.1111/j.1464-5491.2011.03544.x

Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

A Kaas, Claudia Christina Pfleger, A V Kharagjitsingh, N C Schloot, Lars Hansen, K Buschard, B P C Koeleman, B O Roep, H B Mortensen, B Z Alizadeh, on behalf of the Hvidoere Study Group on Childhood Diabetes

23 Citationer (Scopus)

Abstract

Aims: The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFNγ) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods: Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFNγ gene were genotyped and serum levels of IL-10 and IFNγ were measured at 1, 6 and 12 months. Results: IL-10 decreased (P

Originalsprog	Engelsk
Tidsskrift	Diabetic Medicine
Vol/bind	29
Udgave nummer	6
Sider (fra-til)	734-741
Antal sider	8
ISSN	0742-3071
DOI	https://doi.org/10.1111/j.1464-5491.2011.03544.x
Status	Udgivet - 2012

Adgang til dokumentet

10.1111/j.1464-5491.2011.03544.x

Andre filer og links

Link to publication in Scopus

Citationsformater

Kaas, A., Pfleger, C. C., Kharagjitsingh, A. V., Schloot, N. C., Hansen, L., Buschard, K., Koeleman, B. P. C., Roep, B. O., Mortensen, H. B., Alizadeh, B. Z., & on behalf of the Hvidoere Study Group on Childhood Diabetes (2012). Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes. Diabetic Medicine, 29(6), 734-741. https://doi.org/10.1111/j.1464-5491.2011.03544.x

Kaas, A, Pfleger, CC, Kharagjitsingh, AV, Schloot, NC, Hansen, L, Buschard, K, Koeleman, BPC, Roep, BO, Mortensen, HB, Alizadeh, BZ & on behalf of the Hvidoere Study Group on Childhood Diabetes 2012, 'Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes', Diabetic Medicine, bind 29, nr. 6, s. 734-741. https://doi.org/10.1111/j.1464-5491.2011.03544.x

@article{2358b25b9e3c4cbbb05f1cbd4793fe02,

title = "Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes",

abstract = "Aims: The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFNγ) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods: Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFNγ gene were genotyped and serum levels of IL-10 and IFNγ were measured at 1, 6 and 12 months. Results: IL-10 decreased (P ",

author = "A Kaas and Pfleger, \{Claudia Christina\} and Kharagjitsingh, \{A V\} and Schloot, \{N C\} and Lars Hansen and K Buschard and Koeleman, \{B P C\} and Roep, \{B O\} and Mortensen, \{H B\} and Alizadeh, \{B Z\} and \{on behalf of the Hvidoere Study Group on Childhood Diabetes\}",

note = "{\textcopyright} 2011 The Authors. Diabetic Medicine {\textcopyright} 2011 Diabetes UK.",

year = "2012",

doi = "10.1111/j.1464-5491.2011.03544.x",

language = "English",

volume = "29",

pages = "734--741",

journal = "Diabetic Medicine",

issn = "0742-3071",

publisher = "Wiley",

number = "6",

}

TY - JOUR

T1 - Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

AU - Kaas, A

AU - Pfleger, Claudia Christina

AU - Kharagjitsingh, A V

AU - Schloot, N C

AU - Hansen, Lars

AU - Buschard, K

AU - Koeleman, B P C

AU - Roep, B O

AU - Mortensen, H B

AU - Alizadeh, B Z

AU - on behalf of the Hvidoere Study Group on Childhood Diabetes

PY - 2012

Y1 - 2012

N2 - Aims: The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFNγ) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods: Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFNγ gene were genotyped and serum levels of IL-10 and IFNγ were measured at 1, 6 and 12 months. Results: IL-10 decreased (P

AB - Aims: The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFNγ) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods: Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFNγ gene were genotyped and serum levels of IL-10 and IFNγ were measured at 1, 6 and 12 months. Results: IL-10 decreased (P

UR - https://www.scopus.com/pages/publications/84861112640

U2 - 10.1111/j.1464-5491.2011.03544.x

DO - 10.1111/j.1464-5491.2011.03544.x

M3 - Journal article

C2 - 22150609

SN - 0742-3071

VL - 29

SP - 734

EP - 741

JO - Diabetic Medicine

JF - Diabetic Medicine

IS - 6

ER -

Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

Abstract

Adgang til dokumentet

Andre filer og links

Fingeraftryk

Citationsformater