Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

A Kaas; Claudia Christina Pfleger; A V Kharagjitsingh; N C Schloot; Lars  Hansen; K Buschard; B P C Koeleman; B O Roep; H B Mortensen; B Z Alizadeh; on behalf of the Hvidoere Study Group on Childhood Diabetes

doi:10.1111/j.1464-5491.2011.03544.x

Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

A Kaas, Claudia Christina Pfleger, A V Kharagjitsingh, N C Schloot, Lars Hansen, K Buschard, B P C Koeleman, B O Roep, H B Mortensen, B Z Alizadeh, on behalf of the Hvidoere Study Group on Childhood Diabetes

22 Citationer (Scopus)

Abstract

Aims: The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFNγ) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods: Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFNγ gene were genotyped and serum levels of IL-10 and IFNγ were measured at 1, 6 and 12 months. Results: IL-10 decreased (P

Originalsprog	Engelsk
Tidsskrift	Diabetic Medicine
Vol/bind	29
Udgave nummer	6
Sider (fra-til)	734-741
Antal sider	8
ISSN	0742-3071
DOI	https://doi.org/10.1111/j.1464-5491.2011.03544.x
Status	Udgivet - 2012

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10.1111/j.1464-5491.2011.03544.x

Citationsformater

Kaas, A., Pfleger, C. C., Kharagjitsingh, A. V., Schloot, N. C., Hansen, L., Buschard, K., Koeleman, B. P. C., Roep, B. O., Mortensen, H. B., Alizadeh, B. Z., & on behalf of the Hvidoere Study Group on Childhood Diabetes (2012). Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes. Diabetic Medicine, 29(6), 734-741. https://doi.org/10.1111/j.1464-5491.2011.03544.x

Kaas, A, Pfleger, CC, Kharagjitsingh, AV, Schloot, NC, Hansen, L, Buschard, K, Koeleman, BPC, Roep, BO, Mortensen, HB, Alizadeh, BZ & on behalf of the Hvidoere Study Group on Childhood Diabetes 2012, 'Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes', Diabetic Medicine, bind 29, nr. 6, s. 734-741. https://doi.org/10.1111/j.1464-5491.2011.03544.x

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title = "Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes",

abstract = "Aims: The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFNγ) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods: Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFNγ gene were genotyped and serum levels of IL-10 and IFNγ were measured at 1, 6 and 12 months. Results: IL-10 decreased (P ",

author = "A Kaas and Pfleger, {Claudia Christina} and Kharagjitsingh, {A V} and Schloot, {N C} and Lars Hansen and K Buschard and Koeleman, {B P C} and Roep, {B O} and Mortensen, {H B} and Alizadeh, {B Z} and {on behalf of the Hvidoere Study Group on Childhood Diabetes}",

note = "{\textcopyright} 2011 The Authors. Diabetic Medicine {\textcopyright} 2011 Diabetes UK.",

year = "2012",

doi = "10.1111/j.1464-5491.2011.03544.x",

language = "English",

volume = "29",

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T1 - Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

AU - Kaas, A

AU - Pfleger, Claudia Christina

AU - Kharagjitsingh, A V

AU - Schloot, N C

AU - Hansen, Lars

AU - Buschard, K

AU - Koeleman, B P C

AU - Roep, B O

AU - Mortensen, H B

AU - Alizadeh, B Z

AU - on behalf of the Hvidoere Study Group on Childhood Diabetes

PY - 2012

Y1 - 2012

N2 - Aims: The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFNγ) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods: Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFNγ gene were genotyped and serum levels of IL-10 and IFNγ were measured at 1, 6 and 12 months. Results: IL-10 decreased (P

AB - Aims: The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFNγ) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes. Methods: Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFNγ gene were genotyped and serum levels of IL-10 and IFNγ were measured at 1, 6 and 12 months. Results: IL-10 decreased (P

U2 - 10.1111/j.1464-5491.2011.03544.x

DO - 10.1111/j.1464-5491.2011.03544.x

M3 - Journal article

C2 - 22150609

SN - 0742-3071

VL - 29

SP - 734

EP - 741

JO - Diabetic Medicine

JF - Diabetic Medicine

IS - 6

ER -

Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

Abstract

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