Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise

Sibel Z Aydin; Haner Direskeneli; Peter A Merkel; International Delphi on Disease Activity Assessment in Large-vessel Vasculitis (Bo Baslund, Mikkel Faurschou and others); Bo Baslund; Mikkel Faurschou

doi:10.3899/jrheum.161269

Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise

Sibel Z Aydin, Haner Direskeneli, Peter A Merkel, International Delphi on Disease Activity Assessment in Large-vessel Vasculitis (Bo Baslund, Mikkel Faurschou and others), Bo Baslund (Medlem af forfattergruppering), Mikkel Faurschou (Medlem af forfattergruppering)

Afdeling for Rygkirurgi, Led- og Bindevævssygdomme HOC

28 Citationer (Scopus)

Abstract

OBJECTIVE: To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials.

METHODS: A Delphi survey including 99 items was circulated among international experts for 3 rounds.

RESULTS: Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging.

CONCLUSION: This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.

Originalsprog	Engelsk
Tidsskrift	Journal of Rheumatology
Vol/bind	44
Udgave nummer	12
Sider (fra-til)	1928-1932
Antal sider	5
ISSN	0315-162X
DOI	https://doi.org/10.3899/jrheum.161269
Status	Udgivet - dec. 2017

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10.3899/jrheum.161269

Citationsformater

Aydin, S. Z., Direskeneli, H., Merkel, P. A., International Delphi on Disease Activity Assessment in Large-vessel Vasculitis (Bo Baslund, Mikkel Faurschou and others), Baslund, B., & Faurschou, M. (2017). Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise. Journal of Rheumatology, 44(12), 1928-1932. https://doi.org/10.3899/jrheum.161269

Aydin, SZ, Direskeneli, H, Merkel, PA, International Delphi on Disease Activity Assessment in Large-vessel Vasculitis (Bo Baslund, Mikkel Faurschou and others), Baslund, B & Faurschou, M 2017, 'Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise', Journal of Rheumatology, bind 44, nr. 12, s. 1928-1932. https://doi.org/10.3899/jrheum.161269

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N2 - OBJECTIVE: To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials.METHODS: A Delphi survey including 99 items was circulated among international experts for 3 rounds.RESULTS: Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging.CONCLUSION: This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.

AB - OBJECTIVE: To arrive at consensus for candidate outcomes for disease activity assessment in large-vessel vasculitis (LVV) in clinical trials.METHODS: A Delphi survey including 99 items was circulated among international experts for 3 rounds.RESULTS: Fifty-seven items were accepted for both giant cell arteritis and Takayasu arteritis. Sixty-seven percent of experts voted to have a common approach for both diseases with additional disease-specific items such as weight loss, scalp tenderness/necrosis, morning stiffness, dizziness, visual symptoms, and imaging.CONCLUSION: This study highlights similarities and differences in experts' perspectives for assessing clinical activity in LVV and may guide a consensus-driven core set of validated outcomes.

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Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise

Abstract

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