Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Assessment of acute bone loading in humans using [18F]NaF PET/MRI

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. EANM position paper on the role of radiobiology in nuclear medicine

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Impact of the COVID-19 pandemic on nuclear medicine departments in Europe

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Finding our way through the labyrinth of dementia biomarkers

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  4. EANM/SNMMI practice guideline for [18F]FDG PET/CT external beam radiotherapy treatment planning in uterine cervical cancer v1.0

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The Arg82Cys polymorphism of the protein Nepmucin implies a role in HDL metabolism

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Administration of whey protein complexed vitamin D3 to vitamin D3-deficient growing Sprague-Dawley rats

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Bone involvement in patients with spondyloarthropathies

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Effects of calcium source, inulin, and lactose on gut-bone associations in an ovarierectomized rat model

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Patients with cirrhosis have elevated bone turnover but normal hepatic production of osteoprotegerin

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Purpose: The acute effect of loading on bone tissue and physiology can offer important information with regard to joint function in diseases such as osteoarthritis. Imaging studies using [ 18F]-sodium fluoride ([ 18F]NaF) have found changes in tracer kinetics in animals after subjecting bones to strain, indicating an acute physiological response. The aim of this study is to measure acute changes in NaF uptake in human bone due to exercise-induced loading. Methods: Twelve healthy subjects underwent two consecutive 50-min [ 18F]NaF PET/MRI examinations of the knees, one baseline followed by one post-exercise scan. Quantification of tracer kinetics was performed using an image-derived input function from the popliteal artery. For both scans, kinetic parameters of K i NLR, K 1, k 2, k 3, and blood volume were mapped parametrically using nonlinear regression with the Hawkins model. The kinetic parameters along with mean SUV and SUV max were compared between the pre- and post-exercise examinations. Differences in response to exercise were analysed between bone tissue types (subchondral, cortical, and trabecular bone) and between regional subsections of knee subchondral bone. Results: Exercise induced a significant (p < <0.001) increase in [ 18F]NaF uptake in all bone tissues in both knees, with mean SUV increases ranging from 47% in trabecular bone tissue to 131% in subchondral bone tissue. Kinetic parameters involving vascularization (K 1 and blood volume) increased, whereas the NaF extraction fraction [k 3/(k 2 + k 3)] was reduced. Conclusions: Bone loading induces an acute response in bone physiology as quantified by [ 18F]NaF PET kinetics. Dynamic imaging after bone loading using [ 18F]NaF PET is a promising diagnostic tool in bone physiology and imaging of biomechanics.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Nuclear Medicine and Molecular Imaging
Vol/bind46
Udgave nummer12
Sider (fra-til)2452-2463
Antal sider12
ISSN1619-7070
DOI
StatusUdgivet - nov. 2019

ID: 58367543