Assessment of a new model of glucagon action with glucagon receptor dynamics

Clara Furió-Novejarque; Ricardo Sanz; Asbjørn Thode Reenberg; Tobias K.S. Ritschel; Ajenthen G. Ranjan; Kirsten Nørgaard; Jose Luis Díez; John Bagterp Jørgensen; Jorge Bondia

doi:10.1016/j.ifacol.2022.09.169

Assessment of a new model of glucagon action with glucagon receptor dynamics

Clara Furió-Novejarque, Ricardo Sanz, Asbjørn Thode Reenberg, Tobias K.S. Ritschel, Ajenthen G. Ranjan, Kirsten Nørgaard, Jose Luis Díez, John Bagterp Jørgensen, Jorge Bondia^*

^*Corresponding author af dette arbejde

3 Citationer (Scopus)

Abstract

In this work, a novel insulin-glucagon-glucose model is proposed, where the glucagon effect on the endogenous glucose production (EGP) is described by the dynamics of the glucagon receptors. In order to assess the quality of the model, its parameters are fitted in such a way that the influence of glucagon on EGP is isolated. Experimental data is used to validate the model structure and show that the receptor dynamics allow to explain some of the glucagon-related phenomena observed in the clinical data. This physiology-focused model will be useful in the development of artificial pancreas algorithms both for more realistic in silico validations and in the development of model-based control strategies.

Originalsprog	Engelsk
Tidsskrift	IFAC-PapersOnLine
Vol/bind	55
Udgave nummer	20
Sider (fra-til)	647-652
Antal sider	6
ISSN	2405-8963
DOI	https://doi.org/10.1016/j.ifacol.2022.09.169
Status	Udgivet - 1 jul. 2022
Begivenhed	10th Vienna International Conference on Mathematical Modelling, MATHMOD 2022 - Vienna, Østrig Varighed: 27 jul. 2022 → 29 jul. 2022

Konference

Konference	10th Vienna International Conference on Mathematical Modelling, MATHMOD 2022
Land/Område	Østrig
By	Vienna
Periode	27/07/2022 → 29/07/2022
Sponsor	ARGESIM Arbeitsgemeinschaft Simulation, et al., International Federation of Automatic Control, Osterreichische Gesellschaft fur Mess-, Automatisierung- und Robotertechnik (GMAR), Technische Universitat Wien, VDI/VDE Society Measurement and Automatic Control

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10.1016/j.ifacol.2022.09.169

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title = "Assessment of a new model of glucagon action with glucagon receptor dynamics",

abstract = "In this work, a novel insulin-glucagon-glucose model is proposed, where the glucagon effect on the endogenous glucose production (EGP) is described by the dynamics of the glucagon receptors. In order to assess the quality of the model, its parameters are fitted in such a way that the influence of glucagon on EGP is isolated. Experimental data is used to validate the model structure and show that the receptor dynamics allow to explain some of the glucagon-related phenomena observed in the clinical data. This physiology-focused model will be useful in the development of artificial pancreas algorithms both for more realistic in silico validations and in the development of model-based control strategies.",

keywords = "clinical data, Diabetes, glucagon receptors, parameter estimation, PK-PD model",

author = "Clara Furi{\'o}-Novejarque and Ricardo Sanz and Reenberg, {Asbj{\o}rn Thode} and Ritschel, {Tobias K.S.} and Ranjan, {Ajenthen G.} and Kirsten N{\o}rgaard and D{\'i}ez, {Jose Luis} and J{\o}rgensen, {John Bagterp} and Jorge Bondia",

note = "Funding Information: This work was partially supported by: grant DPI2016-78831-C2-1-R funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”; grants PID2019-107722RB-C21, FPU17/03404 and EST19/00740, funded by MCIN/AEI/10.13039/501100011033; the IFD Grand solution project ADAPT-T2D (9068-00056B). Publisher Copyright: {\textcopyright} 2022 The Authors.; 10th Vienna International Conference on Mathematical Modelling, MATHMOD 2022 ; Conference date: 27-07-2022 Through 29-07-2022",

year = "2022",

month = jul,

day = "1",

doi = "10.1016/j.ifacol.2022.09.169",

language = "English",

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T1 - Assessment of a new model of glucagon action with glucagon receptor dynamics

AU - Furió-Novejarque, Clara

AU - Sanz, Ricardo

AU - Reenberg, Asbjørn Thode

AU - Ritschel, Tobias K.S.

AU - Ranjan, Ajenthen G.

AU - Nørgaard, Kirsten

AU - Díez, Jose Luis

AU - Jørgensen, John Bagterp

AU - Bondia, Jorge

N1 - Funding Information: This work was partially supported by: grant DPI2016-78831-C2-1-R funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”; grants PID2019-107722RB-C21, FPU17/03404 and EST19/00740, funded by MCIN/AEI/10.13039/501100011033; the IFD Grand solution project ADAPT-T2D (9068-00056B). Publisher Copyright: © 2022 The Authors.

PY - 2022/7/1

Y1 - 2022/7/1

N2 - In this work, a novel insulin-glucagon-glucose model is proposed, where the glucagon effect on the endogenous glucose production (EGP) is described by the dynamics of the glucagon receptors. In order to assess the quality of the model, its parameters are fitted in such a way that the influence of glucagon on EGP is isolated. Experimental data is used to validate the model structure and show that the receptor dynamics allow to explain some of the glucagon-related phenomena observed in the clinical data. This physiology-focused model will be useful in the development of artificial pancreas algorithms both for more realistic in silico validations and in the development of model-based control strategies.

AB - In this work, a novel insulin-glucagon-glucose model is proposed, where the glucagon effect on the endogenous glucose production (EGP) is described by the dynamics of the glucagon receptors. In order to assess the quality of the model, its parameters are fitted in such a way that the influence of glucagon on EGP is isolated. Experimental data is used to validate the model structure and show that the receptor dynamics allow to explain some of the glucagon-related phenomena observed in the clinical data. This physiology-focused model will be useful in the development of artificial pancreas algorithms both for more realistic in silico validations and in the development of model-based control strategies.

KW - clinical data

KW - Diabetes

KW - glucagon receptors

KW - parameter estimation

KW - PK-PD model

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U2 - 10.1016/j.ifacol.2022.09.169

DO - 10.1016/j.ifacol.2022.09.169

M3 - Conference article

AN - SCOPUS:85142216875

SN - 2405-8963

VL - 55

SP - 647

EP - 652

JO - IFAC-PapersOnLine

JF - IFAC-PapersOnLine

IS - 20

T2 - 10th Vienna International Conference on Mathematical Modelling, MATHMOD 2022

Y2 - 27 July 2022 through 29 July 2022

ER -

Assessment of a new model of glucagon action with glucagon receptor dynamics

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