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Assessing the genetic architecture of epithelial ovarian cancer histological subtypes

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Harvard

Cuellar-Partida, G, Lu, Y, Dixon, SC, Fasching, PA, Hein, A, Burghaus, S, Beckmann, MW, Lambrechts, D, Van Nieuwenhuysen, E, Vergote, I, Vanderstichele, A, Doherty, JA, Rossing, MA, Chang-Claude, J, Rudolph, A, Wang-Gohrke, S, Goodman, MT, Bogdanova, N, Dörk, T, Dürst, M, Hillemanns, P, Runnebaum, IB, Antonenkova, N, Butzow, R, Leminen, A, Nevanlinna, H, Pelttari, LM, Edwards, RP, Kelley, JL, Modugno, F, Moysich, KB, Ness, RB, Cannioto, R, Høgdall, EVS, Høgdall, C, Jensen, A, Giles, GG, Bruinsma, F, Kjaer, SK, Hildebrandt, MAT, Liang, D, Lu, KH, Wu, X, Bisogna, M, Dao, F, Levine, DA, Cramer, DW, Terry, KL, Tworoger, SS, Stampfer, M & Australian Ovarian Cancer Study 2016, 'Assessing the genetic architecture of epithelial ovarian cancer histological subtypes' Human Genetics, bind 135, nr. 7, s. 741-56. https://doi.org/10.1007/s00439-016-1663-9

APA

Cuellar-Partida, G., Lu, Y., Dixon, S. C., Fasching, P. A., Hein, A., Burghaus, S., ... Australian Ovarian Cancer Study (2016). Assessing the genetic architecture of epithelial ovarian cancer histological subtypes. Human Genetics, 135(7), 741-56. https://doi.org/10.1007/s00439-016-1663-9

CBE

Cuellar-Partida G, Lu Y, Dixon SC, Fasching PA, Hein A, Burghaus S, Beckmann MW, Lambrechts D, Van Nieuwenhuysen E, Vergote I, Vanderstichele A, Doherty JA, Rossing MA, Chang-Claude J, Rudolph A, Wang-Gohrke S, Goodman MT, Bogdanova N, Dörk T, Dürst M, Hillemanns P, Runnebaum IB, Antonenkova N, Butzow R, Leminen A, Nevanlinna H, Pelttari LM, Edwards RP, Kelley JL, Modugno F, Moysich KB, Ness RB, Cannioto R, Høgdall EVS, Høgdall C, Jensen A, Giles GG, Bruinsma F, Kjaer SK, Hildebrandt MAT, Liang D, Lu KH, Wu X, Bisogna M, Dao F, Levine DA, Cramer DW, Terry KL, Tworoger SS, Stampfer M, Australian Ovarian Cancer Study. 2016. Assessing the genetic architecture of epithelial ovarian cancer histological subtypes. Human Genetics. 135(7):741-56. https://doi.org/10.1007/s00439-016-1663-9

MLA

Vancouver

Cuellar-Partida G, Lu Y, Dixon SC, Fasching PA, Hein A, Burghaus S o.a. Assessing the genetic architecture of epithelial ovarian cancer histological subtypes. Human Genetics. 2016 jul;135(7):741-56. https://doi.org/10.1007/s00439-016-1663-9

Author

Cuellar-Partida, Gabriel ; Lu, Yi ; Dixon, Suzanne C ; Fasching, Peter A ; Hein, Alexander ; Burghaus, Stefanie ; Beckmann, Matthias W ; Lambrechts, Diether ; Van Nieuwenhuysen, Els ; Vergote, Ignace ; Vanderstichele, Adriaan ; Doherty, Jennifer Anne ; Rossing, Mary Anne ; Chang-Claude, Jenny ; Rudolph, Anja ; Wang-Gohrke, Shan ; Goodman, Marc T ; Bogdanova, Natalia ; Dörk, Thilo ; Dürst, Matthias ; Hillemanns, Peter ; Runnebaum, Ingo B ; Antonenkova, Natalia ; Butzow, Ralf ; Leminen, Arto ; Nevanlinna, Heli ; Pelttari, Liisa M ; Edwards, Robert P ; Kelley, Joseph L ; Modugno, Francesmary ; Moysich, Kirsten B ; Ness, Roberta B ; Cannioto, Rikki ; Høgdall, Estrid Vilma Solyom ; Høgdall, Claus ; Jensen, Allan ; Giles, Graham G ; Bruinsma, Fiona ; Kjaer, Susanne K ; Hildebrandt, Michelle A T ; Liang, Dong ; Lu, Karen H ; Wu, Xifeng ; Bisogna, Maria ; Dao, Fanny ; Levine, Douglas A ; Cramer, Daniel W ; Terry, Kathryn L ; Tworoger, Shelley S ; Stampfer, Meir ; Australian Ovarian Cancer Study. / Assessing the genetic architecture of epithelial ovarian cancer histological subtypes. I: Human Genetics. 2016 ; Bind 135, Nr. 7. s. 741-56.

Bibtex

@article{6182f3736fcf4850b2a45f1834c1c75e,
title = "Assessing the genetic architecture of epithelial ovarian cancer histological subtypes",
abstract = "Epithelial ovarian cancer (EOC) is one of the deadliest common cancers. The five most common types of disease are high-grade and low-grade serous, endometrioid, mucinous and clear cell carcinoma. Each of these subtypes present distinct molecular pathogeneses and sensitivities to treatments. Recent studies show that certain genetic variants confer susceptibility to all subtypes while other variants are subtype-specific. Here, we perform an extensive analysis of the genetic architecture of EOC subtypes. To this end, we used data of 10,014 invasive EOC patients and 21,233 controls from the Ovarian Cancer Association Consortium genotyped in the iCOGS array (211,155 SNPs). We estimate the array heritability (attributable to variants tagged on arrays) of each subtype and their genetic correlations. We also look for genetic overlaps with factors such as obesity, smoking behaviors, diabetes, age at menarche and height. We estimated the array heritabilities of high-grade serous disease ([Formula: see text] = 8.8 ± 1.1 {\%}), endometrioid ([Formula: see text] = 3.2 ± 1.6 {\%}), clear cell ([Formula: see text] = 6.7 ± 3.3 {\%}) and all EOC ([Formula: see text] = 5.6 ± 0.6 {\%}). Known associated loci contributed approximately 40 {\%} of the total array heritability for each subtype. The contribution of each chromosome to the total heritability was not proportional to chromosome size. Through bivariate and cross-trait LD score regression, we found evidence of shared genetic backgrounds between the three high-grade subtypes: serous, endometrioid and undifferentiated. Finally, we found significant genetic correlations of all EOC with diabetes and obesity using a polygenic prediction approach.",
keywords = "Journal Article",
author = "Gabriel Cuellar-Partida and Yi Lu and Dixon, {Suzanne C} and Fasching, {Peter A} and Alexander Hein and Stefanie Burghaus and Beckmann, {Matthias W} and Diether Lambrechts and {Van Nieuwenhuysen}, Els and Ignace Vergote and Adriaan Vanderstichele and Doherty, {Jennifer Anne} and Rossing, {Mary Anne} and Jenny Chang-Claude and Anja Rudolph and Shan Wang-Gohrke and Goodman, {Marc T} and Natalia Bogdanova and Thilo D{\"o}rk and Matthias D{\"u}rst and Peter Hillemanns and Runnebaum, {Ingo B} and Natalia Antonenkova and Ralf Butzow and Arto Leminen and Heli Nevanlinna and Pelttari, {Liisa M} and Edwards, {Robert P} and Kelley, {Joseph L} and Francesmary Modugno and Moysich, {Kirsten B} and Ness, {Roberta B} and Rikki Cannioto and H{\o}gdall, {Estrid Vilma Solyom} and Claus H{\o}gdall and Allan Jensen and Giles, {Graham G} and Fiona Bruinsma and Kjaer, {Susanne K} and Hildebrandt, {Michelle A T} and Dong Liang and Lu, {Karen H} and Xifeng Wu and Maria Bisogna and Fanny Dao and Levine, {Douglas A} and Cramer, {Daniel W} and Terry, {Kathryn L} and Tworoger, {Shelley S} and Meir Stampfer and {Australian Ovarian Cancer Study}",
year = "2016",
month = "7",
doi = "10.1007/s00439-016-1663-9",
language = "English",
volume = "135",
pages = "741--56",
journal = "Human Genetics",
issn = "0340-6717",
publisher = "Springer",
number = "7",

}

RIS

TY - JOUR

T1 - Assessing the genetic architecture of epithelial ovarian cancer histological subtypes

AU - Cuellar-Partida, Gabriel

AU - Lu, Yi

AU - Dixon, Suzanne C

AU - Fasching, Peter A

AU - Hein, Alexander

AU - Burghaus, Stefanie

AU - Beckmann, Matthias W

AU - Lambrechts, Diether

AU - Van Nieuwenhuysen, Els

AU - Vergote, Ignace

AU - Vanderstichele, Adriaan

AU - Doherty, Jennifer Anne

AU - Rossing, Mary Anne

AU - Chang-Claude, Jenny

AU - Rudolph, Anja

AU - Wang-Gohrke, Shan

AU - Goodman, Marc T

AU - Bogdanova, Natalia

AU - Dörk, Thilo

AU - Dürst, Matthias

AU - Hillemanns, Peter

AU - Runnebaum, Ingo B

AU - Antonenkova, Natalia

AU - Butzow, Ralf

AU - Leminen, Arto

AU - Nevanlinna, Heli

AU - Pelttari, Liisa M

AU - Edwards, Robert P

AU - Kelley, Joseph L

AU - Modugno, Francesmary

AU - Moysich, Kirsten B

AU - Ness, Roberta B

AU - Cannioto, Rikki

AU - Høgdall, Estrid Vilma Solyom

AU - Høgdall, Claus

AU - Jensen, Allan

AU - Giles, Graham G

AU - Bruinsma, Fiona

AU - Kjaer, Susanne K

AU - Hildebrandt, Michelle A T

AU - Liang, Dong

AU - Lu, Karen H

AU - Wu, Xifeng

AU - Bisogna, Maria

AU - Dao, Fanny

AU - Levine, Douglas A

AU - Cramer, Daniel W

AU - Terry, Kathryn L

AU - Tworoger, Shelley S

AU - Stampfer, Meir

AU - Australian Ovarian Cancer Study

PY - 2016/7

Y1 - 2016/7

N2 - Epithelial ovarian cancer (EOC) is one of the deadliest common cancers. The five most common types of disease are high-grade and low-grade serous, endometrioid, mucinous and clear cell carcinoma. Each of these subtypes present distinct molecular pathogeneses and sensitivities to treatments. Recent studies show that certain genetic variants confer susceptibility to all subtypes while other variants are subtype-specific. Here, we perform an extensive analysis of the genetic architecture of EOC subtypes. To this end, we used data of 10,014 invasive EOC patients and 21,233 controls from the Ovarian Cancer Association Consortium genotyped in the iCOGS array (211,155 SNPs). We estimate the array heritability (attributable to variants tagged on arrays) of each subtype and their genetic correlations. We also look for genetic overlaps with factors such as obesity, smoking behaviors, diabetes, age at menarche and height. We estimated the array heritabilities of high-grade serous disease ([Formula: see text] = 8.8 ± 1.1 %), endometrioid ([Formula: see text] = 3.2 ± 1.6 %), clear cell ([Formula: see text] = 6.7 ± 3.3 %) and all EOC ([Formula: see text] = 5.6 ± 0.6 %). Known associated loci contributed approximately 40 % of the total array heritability for each subtype. The contribution of each chromosome to the total heritability was not proportional to chromosome size. Through bivariate and cross-trait LD score regression, we found evidence of shared genetic backgrounds between the three high-grade subtypes: serous, endometrioid and undifferentiated. Finally, we found significant genetic correlations of all EOC with diabetes and obesity using a polygenic prediction approach.

AB - Epithelial ovarian cancer (EOC) is one of the deadliest common cancers. The five most common types of disease are high-grade and low-grade serous, endometrioid, mucinous and clear cell carcinoma. Each of these subtypes present distinct molecular pathogeneses and sensitivities to treatments. Recent studies show that certain genetic variants confer susceptibility to all subtypes while other variants are subtype-specific. Here, we perform an extensive analysis of the genetic architecture of EOC subtypes. To this end, we used data of 10,014 invasive EOC patients and 21,233 controls from the Ovarian Cancer Association Consortium genotyped in the iCOGS array (211,155 SNPs). We estimate the array heritability (attributable to variants tagged on arrays) of each subtype and their genetic correlations. We also look for genetic overlaps with factors such as obesity, smoking behaviors, diabetes, age at menarche and height. We estimated the array heritabilities of high-grade serous disease ([Formula: see text] = 8.8 ± 1.1 %), endometrioid ([Formula: see text] = 3.2 ± 1.6 %), clear cell ([Formula: see text] = 6.7 ± 3.3 %) and all EOC ([Formula: see text] = 5.6 ± 0.6 %). Known associated loci contributed approximately 40 % of the total array heritability for each subtype. The contribution of each chromosome to the total heritability was not proportional to chromosome size. Through bivariate and cross-trait LD score regression, we found evidence of shared genetic backgrounds between the three high-grade subtypes: serous, endometrioid and undifferentiated. Finally, we found significant genetic correlations of all EOC with diabetes and obesity using a polygenic prediction approach.

KW - Journal Article

U2 - 10.1007/s00439-016-1663-9

DO - 10.1007/s00439-016-1663-9

M3 - Journal article

VL - 135

SP - 741

EP - 756

JO - Human Genetics

JF - Human Genetics

SN - 0340-6717

IS - 7

ER -

ID: 49501139