Aspergillus flavus Infections in Children With Leukemia Despite Liposomal Amphotericin-B Prophylaxis

2 Citationer (Scopus)

Abstract

Liposomal amphotericin-B (L-AmB) prophylaxis is used in children with leukemia when azoles are contraindicated, but its effect is debated. We reviewed cases of invasive aspergillosis despite L-AmB 2.5 mg/kg twice weekly in children with high-risk leukemia during 2012-2019. Ten (16%) of 62 children had proven or probable aspergillosis. Thus, L-AmB prophylaxis offered insufficient protection for Aspergillus, in particular for Aspergillus flavus.

OriginalsprogEngelsk
TidsskriftThe Pediatric infectious disease journal
Vol/bind40
Udgave nummer8
Sider (fra-til)749-752
Antal sider4
ISSN0891-3668
DOI
StatusUdgivet - 1 aug. 2021

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