Aspergillus flavus Infections in Children With Leukemia Despite Liposomal Amphotericin-B Prophylaxis

Nadja Hawwa Vissing; Birgitte Lausen; Marianne Hutchings Hoffmann; Bodil Als-Nielsen; Kjeld Schmiegelow; Jannik Helweg-Larsen; Maiken Cavling Arendrup; Ulrikka Nygaard

doi:10.1097/INF.0000000000003189

Aspergillus flavus Infections in Children With Leukemia Despite Liposomal Amphotericin-B Prophylaxis

Nadja Hawwa Vissing, Birgitte Lausen, Marianne Hutchings Hoffmann, Bodil Als-Nielsen, Kjeld Schmiegelow, Jannik Helweg-Larsen, Maiken Cavling Arendrup, Ulrikka Nygaard

4 Citationer (Scopus)

Abstract

Liposomal amphotericin-B (L-AmB) prophylaxis is used in children with leukemia when azoles are contraindicated, but its effect is debated. We reviewed cases of invasive aspergillosis despite L-AmB 2.5 mg/kg twice weekly in children with high-risk leukemia during 2012-2019. Ten (16%) of 62 children had proven or probable aspergillosis. Thus, L-AmB prophylaxis offered insufficient protection for Aspergillus, in particular for Aspergillus flavus.

Originalsprog	Engelsk
Tidsskrift	The Pediatric infectious disease journal
Vol/bind	40
Udgave nummer	8
Sider (fra-til)	749-752
Antal sider	4
ISSN	0891-3668
DOI	https://doi.org/10.1097/INF.0000000000003189
Status	Udgivet - 1 aug. 2021

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title = "Aspergillus flavus Infections in Children With Leukemia Despite Liposomal Amphotericin-B Prophylaxis",

abstract = "Liposomal amphotericin-B (L-AmB) prophylaxis is used in children with leukemia when azoles are contraindicated, but its effect is debated. We reviewed cases of invasive aspergillosis despite L-AmB 2.5 mg/kg twice weekly in children with high-risk leukemia during 2012-2019. Ten (16%) of 62 children had proven or probable aspergillosis. Thus, L-AmB prophylaxis offered insufficient protection for Aspergillus, in particular for Aspergillus flavus.",

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AU - Vissing, Nadja Hawwa

AU - Lausen, Birgitte

AU - Hutchings Hoffmann, Marianne

AU - Als-Nielsen, Bodil

AU - Schmiegelow, Kjeld

AU - Helweg-Larsen, Jannik

AU - Arendrup, Maiken Cavling

AU - Nygaard, Ulrikka

PY - 2021/8/1

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N2 - Liposomal amphotericin-B (L-AmB) prophylaxis is used in children with leukemia when azoles are contraindicated, but its effect is debated. We reviewed cases of invasive aspergillosis despite L-AmB 2.5 mg/kg twice weekly in children with high-risk leukemia during 2012-2019. Ten (16%) of 62 children had proven or probable aspergillosis. Thus, L-AmB prophylaxis offered insufficient protection for Aspergillus, in particular for Aspergillus flavus.

AB - Liposomal amphotericin-B (L-AmB) prophylaxis is used in children with leukemia when azoles are contraindicated, but its effect is debated. We reviewed cases of invasive aspergillosis despite L-AmB 2.5 mg/kg twice weekly in children with high-risk leukemia during 2012-2019. Ten (16%) of 62 children had proven or probable aspergillosis. Thus, L-AmB prophylaxis offered insufficient protection for Aspergillus, in particular for Aspergillus flavus.

KW - Adolescent

KW - Amphotericin B/therapeutic use

KW - Antifungal Agents/therapeutic use

KW - Aspergillosis/prevention & control

KW - Aspergillus flavus/drug effects

KW - Child

KW - Child, Preschool

KW - Denmark/epidemiology

KW - Hospitals, Pediatric

KW - Humans

KW - Infant

KW - Leukemia/complications

KW - Retrospective Studies

KW - invasive fungal disease

KW - Aspergillus flavus

KW - prophylaxis

KW - pediatric leukemia

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U2 - 10.1097/INF.0000000000003189

DO - 10.1097/INF.0000000000003189

M3 - Journal article

C2 - 34250973

SN - 0891-3668

VL - 40

SP - 749

EP - 752

JO - The Pediatric infectious disease journal

JF - The Pediatric infectious disease journal

IS - 8

ER -

Aspergillus flavus Infections in Children With Leukemia Despite Liposomal Amphotericin-B Prophylaxis

Abstract

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