Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

ASD and schizophrenia show distinct developmental profiles in common genetic overlap with population-based social communication difficulties

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. A major role for common genetic variation in anxiety disorders

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The Duffy-null genotype and risk of infection

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • B St Pourcain
  • E B Robinson
  • V Anttila
  • B B Sullivan
  • J Maller
  • J Golding
  • D Skuse
  • S Ring
  • D M Evans
  • S Zammit
  • S E Fisher
  • B M Neale
  • R J L Anney
  • S Ripke
  • M V Hollegaard
  • T Werge
  • A Ronald
  • J Grove
  • D M Hougaard
  • A D Børglum
  • P B Mortensen
  • M J Daly
  • G Davey Smith
  • iPSYCH-SSI-Broad Autism Group
Vis graf over relationer

Difficulties in social communication are part of the phenotypic overlap between autism spectrum disorders (ASD) and schizophrenia. Both conditions follow, however, distinct developmental patterns. Symptoms of ASD typically occur during early childhood, whereas most symptoms characteristic of schizophrenia do not appear before early adulthood. We investigated whether overlap in common genetic influences between these clinical conditions and impairments in social communication depends on the developmental stage of the assessed trait. Social communication difficulties were measured in typically-developing youth (Avon Longitudinal Study of Parents and Children, N⩽5553, longitudinal assessments at 8, 11, 14 and 17 years) using the Social Communication Disorder Checklist. Data on clinical ASD (PGC-ASD: 5305 cases, 5305 pseudo-controls; iPSYCH-ASD: 7783 cases, 11 359 controls) and schizophrenia (PGC-SCZ2: 34 241 cases, 45 604 controls, 1235 trios) were either obtained through the Psychiatric Genomics Consortium (PGC) or the Danish iPSYCH project. Overlap in genetic influences between ASD and social communication difficulties during development decreased with age, both in the PGC-ASD and the iPSYCH-ASD sample. Genetic overlap between schizophrenia and social communication difficulties, by contrast, persisted across age, as observed within two independent PGC-SCZ2 subsamples, and showed an increase in magnitude for traits assessed during later adolescence. ASD- and schizophrenia-related polygenic effects were unrelated to each other and changes in trait-disorder links reflect the heterogeneity of genetic factors influencing social communication difficulties during childhood versus later adolescence. Thus, both clinical ASD and schizophrenia share some genetic influences with impairments in social communication, but reveal distinct developmental profiles in their genetic links, consistent with the onset of clinical symptoms.Molecular Psychiatry advance online publication, 3 January 2017; doi:10.1038/mp.2016.198.

OriginalsprogEngelsk
TidsskriftMolecular Psychiatry
ISSN1359-4184
DOI
StatusUdgivet - 3 jan. 2017

ID: 49758741