Array-based genomic screening at diagnosis and during follow-up in chronic lymphocytic leukemia

Rebeqa Gunnarsson, Larry Mansouri, Anders Isaksson, Hanna Göransson, Nicola Cahill, Mattias Jansson, Markus Rasmussen, Jeanette De Sparra Lundin, Stefan Norin, Anne Mette Buhl, Karin Ekström Smedby, Henrik Hjalgrim, Karin Karlsson, Jesper Jurlander, Christian Geisler, Gunnar Juliusson, Richard Rosenquist

    85 Citationer (Scopus)

    Abstract

    High-resolution genomic microarrays enable simultaneous detection of copy-number aberrations such as the known recurrent aberrations in chronic lymphocytic leukemia [del(11q), del(13q), del(17p) and trisomy 12], and copy-number neutral loss of heterozygosity. Moreover, comparison of genomic profiles from sequential patients' samples allows detection of clonal evolution.
    OriginalsprogEngelsk
    TidsskriftHaematologica
    Vol/bind96
    Udgave nummer8
    Sider (fra-til)1161-9
    Antal sider9
    ISSN0390-6078
    DOI
    StatusUdgivet - 2011

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