TY - JOUR
T1 - Are we closer to achieving precision medicine for migraine treatment?
T2 - A narrative review
AU - Ihara, Keiko
AU - Casillo, Francesco
AU - Dahshan, Ahmed
AU - Genç, Hamit
AU - Jusupova, Asel
AU - Karbozova, Kunduz
AU - Lee, Wonwoo
AU - Liaw, Yi Chia
AU - Mavridis, Theodoros
AU - Park, Hong-Kyun
AU - Polat, Burcu
AU - Unt, Triin Helin
AU - Vashchenko, Nina
AU - Zhantleuova, Aisha
AU - Pozo-Rosich, Patricia
AU - Schwedt, Todd J
PY - 2024/9
Y1 - 2024/9
N2 - BACKGROUND: The term 'precision medicine' encompasses strategies to optimize diagnosis and outcome prediction and to tailor treatment for individual patients, in consideration of their unique characteristics. The greater availability of multifaceted datasets and strategies to model such data have made precision medicine increasingly possible in recent years. Precision medicine is especially needed in the migraine field since the response to migraine treatments is not universal amongst all individuals with migraine.OBJECTIVE: To provide a narrative review describing contributions to achieving precision medicine for migraine treatment.METHODS: A search of PubMed for English language articles of human participants published from 2005 to January 2024 was conducted to identify articles that reported research contributing to precision medicine for migraine treatment. The published literature was categorized and summarized according to the type of data that were included: clinical phenotypes, genomics, proteomics, physiologic measures, and brain imaging.RESULTS: Published studies have investigated characteristics associated with acute and preventive treatment responses, such as nonsteroidal anti-inflammatory drugs, triptans, onabotulinumtoxinA, and anti-calcitonin gene-related peptide monoclonal antibodies, in patients with episodic or chronic migraine. There is evidence that clinical, genetic, epigenetic, proteomic, physiologic, and brain imaging features might associate with migraine treatment outcomes, although inconsistencies for such findings clearly exist.CONCLUSIONS: The published literature suggests that there are clinical and biological features which associate with, and might be useful for predicting, migraine treatment responses. To achieve precision medicine for migraine treatment, further research is needed that validates and expands on existing findings and tests the accuracy and value of migraine treatment prediction models in clinical settings.
AB - BACKGROUND: The term 'precision medicine' encompasses strategies to optimize diagnosis and outcome prediction and to tailor treatment for individual patients, in consideration of their unique characteristics. The greater availability of multifaceted datasets and strategies to model such data have made precision medicine increasingly possible in recent years. Precision medicine is especially needed in the migraine field since the response to migraine treatments is not universal amongst all individuals with migraine.OBJECTIVE: To provide a narrative review describing contributions to achieving precision medicine for migraine treatment.METHODS: A search of PubMed for English language articles of human participants published from 2005 to January 2024 was conducted to identify articles that reported research contributing to precision medicine for migraine treatment. The published literature was categorized and summarized according to the type of data that were included: clinical phenotypes, genomics, proteomics, physiologic measures, and brain imaging.RESULTS: Published studies have investigated characteristics associated with acute and preventive treatment responses, such as nonsteroidal anti-inflammatory drugs, triptans, onabotulinumtoxinA, and anti-calcitonin gene-related peptide monoclonal antibodies, in patients with episodic or chronic migraine. There is evidence that clinical, genetic, epigenetic, proteomic, physiologic, and brain imaging features might associate with migraine treatment outcomes, although inconsistencies for such findings clearly exist.CONCLUSIONS: The published literature suggests that there are clinical and biological features which associate with, and might be useful for predicting, migraine treatment responses. To achieve precision medicine for migraine treatment, further research is needed that validates and expands on existing findings and tests the accuracy and value of migraine treatment prediction models in clinical settings.
KW - Humans
KW - Migraine Disorders/drug therapy
KW - Precision Medicine/methods
UR - http://www.scopus.com/inward/record.url?scp=85204035734&partnerID=8YFLogxK
U2 - 10.1177/03331024241281518
DO - 10.1177/03331024241281518
M3 - Review
C2 - 39256924
SN - 0333-1024
VL - 44
SP - 3331024241281518
JO - Cephalalgia : an international journal of headache
JF - Cephalalgia : an international journal of headache
IS - 9
ER -