Are self-disorders in schizophrenia expressive of a unifying disturbance of subjectivity: A factor analytic approach

Julie Nordgaard*, Jonas Berge, Andreas Rosén Rasmussen, Karl Erik Sandsten, Maja Zandersen, Josef Stefan Stanislaw Parnas

*Corresponding author af dette arbejde
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Abstract

Background and Hypothesis
The idea that a disorder of the basic self is a central feature in schizophrenia has recently been corroborated in a meta-analysis and a systematic review. Manifestations of the self-disorder can be systematically explored with the Examination of Anomalous Self-Experience (EASE). In this study we examined the factorial structure of EASE, and diagnostic efficacy of EASE.
We hypothesized that EASE will have a monofactorial structure as an instability of the basic self will result in multiple deformations of self-experience which would be meaningfully interrelated as aspects of a unifying Gestalt.
Design
EASE data for 226 patients suffering from various mental disorders were analyzed under a confirmatory factor analysis framework (CFA). Area under the receiver operating characteristic curve (AUC) was calculated for the total EASE sums, and sensitivity and specificity values for prediction of schizophrenia spectrum disorders based on different cut-offs were obtained.
Results
Fit indices for the CFA model: RMSEA = 0.036, SRMR = 0.100, CFI = 0.983, TLI = 0.981. The AUC value was 0.946 (95% confidence interval: 0.919-0.974). Sensitivity as well as specificity for schizophrenia spectrum disorders were high.
Conclusion
Our results lend support for EASE exhibiting a monofactorial structure and the notion of self-disorders as a central phenotypic feature of schizophrenia spectrum disorders.
OriginalsprogEngelsk
TidsskriftSchizophrenia Bulletin
Vol/bind49
Udgave nummer1
Sider (fra-til)144-150
Antal sider7
ISSN0586-7614
StatusUdgivet - 2023

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