Appreciable uncertainty regarding benefits and risks in the treatment of bacterial vaginosis to prevent preterm birth

As part of his speeches, the Roman senator Cato the Elder frequently uttered "Carthago delenda est" (Carthage must be destroyed). Similarly, Lamont and colleagues frequently utter that the "wrong patients with the wrong diagnosis were given wrong antibiotics at the wrong gestational age". We respect that Lamont and colleagues find it difficult to accept meta-analyses, which "cut a toe and a bit of a heel" to merge evidence from more publications, and we certainly cannot exclude the possibility that future research will change clinical practice. However, in contrast to Lamont and colleagues, we emphasize that not only statistical significance but also other aspects should be taken into consideration in the development of clinical recommendations (1). This article is protected by copyright. All rights reserved.