Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Applying insights from biofilm biology to drug development - can a new approach be developed?

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. The discovery of bacterial biofilm in patients with muscle invasive bladder cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Autologous fibrin sealant co-delivered with antibiotics is a robust method for topical antibiotic treatment after sinus surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Azithromycin potentiates avian IgY effect against Pseudomonas aeruginosa in a murine pulmonary infection model

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Adjunctive S100A8/A9 Immunomodulation Hinders Ciprofloxacin Resistance in Pseudomonas aeruginosa in a Murine Biofilm Wound Model

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Antibiotic susceptibility of cystic fibrosis lung microbiome members in a multispecies biofilm

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Most of the research on bacterial pathogenesis has focused on acute infections, but much less is known about the pathogenesis of infections caused by bacteria that grow as aggregates in biofilms. These infections tend to be chronic as they resist innate and adaptive immune defence mechanisms as well as antibiotics, and the treatment of biofilm infections presents a considerable unmet clinical need. To date, there are no drugs that specifically target bacteria in biofilms; however, several approaches are in early-stage development. Here, we review current insights into biofilm physiology and pathology, and discuss how a deep insight into the physical and biological characteristics of biofilms can inform therapeutic strategies and molecular targets for the development of anti-biofilm drugs.
OriginalsprogEngelsk
TidsskriftNature Reviews. Drug Discovery
Vol/bind12
Udgave nummer10
Sider (fra-til)791-808
Antal sider18
ISSN1474-1776
DOI
StatusUdgivet - okt. 2013

ID: 42454022