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Region Hovedstaden - en del af Københavns Universitetshospital
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Applying insights from biofilm biology to drug development - can a new approach be developed?

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. The efficacy of topical agents used in wounds for managing chronic biofilm infections: A systematic review

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The environmental occurrence of Pseudomonas aeruginosa

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Biofilms of Mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Minimum information guideline for spectrofotometric and fluorometric methods to assess biofilm formation in microplates

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Most of the research on bacterial pathogenesis has focused on acute infections, but much less is known about the pathogenesis of infections caused by bacteria that grow as aggregates in biofilms. These infections tend to be chronic as they resist innate and adaptive immune defence mechanisms as well as antibiotics, and the treatment of biofilm infections presents a considerable unmet clinical need. To date, there are no drugs that specifically target bacteria in biofilms; however, several approaches are in early-stage development. Here, we review current insights into biofilm physiology and pathology, and discuss how a deep insight into the physical and biological characteristics of biofilms can inform therapeutic strategies and molecular targets for the development of anti-biofilm drugs.
OriginalsprogEngelsk
TidsskriftNature Reviews. Drug Discovery
Vol/bind12
Udgave nummer10
Sider (fra-til)791-808
Antal sider18
ISSN1474-1776
DOI
StatusUdgivet - okt. 2013

ID: 42454022