Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies

Daniela Perani; Leonardo Iaccarino; Andreas H Jacobs; IMBI Brain Imaging Working Group; Matthias Manfred Herth; Gitte Moos Knudsen

doi:10.1016/j.dadm.2019.02.004

Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies

Daniela Perani, Leonardo Iaccarino, Andreas H Jacobs, IMBI Brain Imaging Working Group, Matthias Manfred Herth (Medlem af forfattergruppering), Gitte Moos Knudsen (Medlem af forfattergruppering)

12 Citationer (Scopus)

Abstract

Introduction: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 "Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration," aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia.

Methods: We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques.

Results: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias.

Discussion: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.

Originalsprog	Engelsk
Tidsskrift	Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Vol/bind	11
Sider (fra-til)	327-332
Antal sider	6
ISSN	2352-8729
DOI	https://doi.org/10.1016/j.dadm.2019.02.004
Status	Udgivet - dec. 2019

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10.1016/j.dadm.2019.02.004

Citationsformater

Perani, D., Iaccarino, L., Jacobs, A. H., IMBI Brain Imaging Working Group, Herth, M. M., & Knudsen, G. M. (2019). Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 11, 327-332. https://doi.org/10.1016/j.dadm.2019.02.004

Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies. / Perani, Daniela; Iaccarino, Leonardo; Jacobs, Andreas H et al.
I: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Bind 11, 12.2019, s. 327-332.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Perani, D, Iaccarino, L, Jacobs, AH, IMBI Brain Imaging Working Group, Herth, MM & Knudsen, GM 2019, 'Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies', Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, bind 11, s. 327-332. https://doi.org/10.1016/j.dadm.2019.02.004

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abstract = "Introduction: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 {"}Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration,{"} aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia.Methods: We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques.Results: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias.Discussion: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.",

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doi = "10.1016/j.dadm.2019.02.004",

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AU - Perani, Daniela

AU - Iaccarino, Leonardo

AU - Jacobs, Andreas H

AU - IMBI Brain Imaging Working Group

A2 - Herth, Matthias Manfred

A2 - Knudsen, Gitte Moos

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AB - Introduction: A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 "Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration," aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia.Methods: We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques.Results: This approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias.Discussion: The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.

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JO - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

JF - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

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Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies

Abstract

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