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Udgivet

Apolipoprotein M/sphingosine-1-phosphate: novel effects on lipids, inflammation and kidney biology

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Remnant lipoproteins

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  2. Relation between plasma and brain lipids

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  3. Using human genetics to predict the effects and side-effects of drugs

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  4. Novel genes in LDL metabolism--a comprehensive overview

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  5. Apolipoprotein M in lipid metabolism and cardiometabolic diseases

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  1. Vascular function in adults with cyanotic congenital heart disease

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  2. Apolipoprotein M and risk of type 2 diabetes

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  3. Effect of insulin on natriuretic peptide gene expression in porcine heart

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  4. Aging suppresses sphingosine-1-phosphate chaperone ApoM in circulation resulting in maladaptive organ repair

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  5. Reduced apolipoprotein M and adverse outcomes across the spectrum of human heart failure

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Vis graf over relationer

PURPOSE OF REVIEW: In 2011, the crystal structure of apolipoprotein M (apoM) and its capacity to bind sphingosine-1-phosphate (S1P) was characterized. Since then, a variety of studies has increased our knowledge on apoM biology and functionality. From being an unknown and hardly significant player in overall metabolism, apoM has gained significant interest.

RECENT FINDINGS: Key discoveries in the last 2 years have indicated that the apoM/S1P complex has important roles in lipid metabolism (affecting triglyceride turnover), inflammation (a marker of severe sepsis and potentially providing anti-inflammatory signaling) and kidney biology (potential to protect against immunoglobulin A nephropathy).

SUMMARY: Several studies suggest a potential for apoM/S1P as biomarkers for inflammation, sepsis and nephropathy. Also, a novel chaperone is characterized and could have potential as a drug for treatment in inflammation and nephropathy.

OriginalsprogEngelsk
TidsskriftCurrent Opinion in Lipidology
Vol/bind30
Udgave nummer3
Sider (fra-til)212-217
Antal sider6
ISSN0957-9672
DOI
StatusUdgivet - jun. 2019

ID: 58250424