TY - JOUR
T1 - Apolipoprotein M/sphingosine-1-phosphate:
T2 - novel effects on lipids, inflammation and kidney biology
AU - Bisgaard, Line S
AU - Christoffersen, Christina
PY - 2019/6
Y1 - 2019/6
N2 - PURPOSE OF REVIEW: In 2011, the crystal structure of apolipoprotein M (apoM) and its capacity to bind sphingosine-1-phosphate (S1P) was characterized. Since then, a variety of studies has increased our knowledge on apoM biology and functionality. From being an unknown and hardly significant player in overall metabolism, apoM has gained significant interest.RECENT FINDINGS: Key discoveries in the last 2 years have indicated that the apoM/S1P complex has important roles in lipid metabolism (affecting triglyceride turnover), inflammation (a marker of severe sepsis and potentially providing anti-inflammatory signaling) and kidney biology (potential to protect against immunoglobulin A nephropathy).SUMMARY: Several studies suggest a potential for apoM/S1P as biomarkers for inflammation, sepsis and nephropathy. Also, a novel chaperone is characterized and could have potential as a drug for treatment in inflammation and nephropathy.
AB - PURPOSE OF REVIEW: In 2011, the crystal structure of apolipoprotein M (apoM) and its capacity to bind sphingosine-1-phosphate (S1P) was characterized. Since then, a variety of studies has increased our knowledge on apoM biology and functionality. From being an unknown and hardly significant player in overall metabolism, apoM has gained significant interest.RECENT FINDINGS: Key discoveries in the last 2 years have indicated that the apoM/S1P complex has important roles in lipid metabolism (affecting triglyceride turnover), inflammation (a marker of severe sepsis and potentially providing anti-inflammatory signaling) and kidney biology (potential to protect against immunoglobulin A nephropathy).SUMMARY: Several studies suggest a potential for apoM/S1P as biomarkers for inflammation, sepsis and nephropathy. Also, a novel chaperone is characterized and could have potential as a drug for treatment in inflammation and nephropathy.
KW - apolipoprotein M
KW - inflammation
KW - nephropathy
KW - sphingosine-1-phosphate
KW - triglyceride
UR - http://www.scopus.com/inward/record.url?scp=85065510469&partnerID=8YFLogxK
U2 - 10.1097/MOL.0000000000000606
DO - 10.1097/MOL.0000000000000606
M3 - Journal article
C2 - 31008738
SN - 0957-9672
VL - 30
SP - 212
EP - 217
JO - Current Opinion in Lipidology
JF - Current Opinion in Lipidology
IS - 3
ER -