Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Apolipoprotein M mediates sphingosine-1-phosphate efflux from erythrocytes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Detection of biological signals from a live mammalian muscle using an early stage diamond quantum sensor

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Infants with congenital heart defects have reduced brain volumes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Interindividual variability of electric fields during transcranial temporal interference stimulation (tTIS)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Using machine learning for predicting intensive care unit resource use during the COVID-19 pandemic in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Apolipoprotein M and its impact on endothelial dysfunction and inflammation in the cardiovascular system

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Apolipoprotein M and Sphingosine-1-Phosphate Receptor 1 promote the transendothelial transport of High-Density Lipoprotein

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Increased plasma apoM levels impair triglyceride turnover in mice

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Oral pre‑treatment with thiocyanate (SCN−) protects against myocardial ischaemia–reperfusion injury in rats

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Sphingosine-1-phosphate (S1P) is a bioactive lipid implicated in e.g. angiogenesis, lymphocyte trafficking, and endothelial barrier function. Erythrocytes are a main source of plasma S1P together with platelets and endothelial cells. Apolipoprotein M (apoM) in HDL carries 70% of plasma S1P, whereas 30% is carried by albumin. The current aim was to investigate the role of apoM in export of S1P from human erythrocytes. Erythrocytes exported S1P more efficiently to HDL than to albumin, particularly when apoM was present in HDL. In contrast, export of sphingosine to HDL was unaffected by the presence of apoM. The specific ability of apoM to promote export of S1P was independent of apoM being bound in HDL particles. Treatment with MK-571, an inhibitor of the ABCC1 transporter, effectively reduced export of S1P from human erythrocytes to apoM, whereas the export was unaffected by inhibitors of ABCB1 or ATPase. Thus, ABCC1 could be involved in export of S1P from erythrocytes to apoM.

OriginalsprogEngelsk
TidsskriftScientific Reports
Vol/bind7
Udgave nummer1
Sider (fra-til)14983
ISSN2045-2322
DOI
StatusUdgivet - 8 nov. 2017

ID: 52077285