Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury

Zhen Guo; Carla Valenzuela Ripoll; Antonino Picataggi; David R Rawnsley; Mualla Ozcan; Julio A Chirinos; Ezhilarasi Chendamarai; Amanda Girardi; Terrence Riehl; Hosannah Evie; Ahmed Diab; Attila Kovacs; Krzysztof Hyrc; Xiucui Ma; Aarti Asnani; Swapnil V Shewale; Marielle Scherrer-Crosbie; Lauren Ashley Cowart; John S Parks; Lei Zhao; David Gordon; Francisco Ramirez-Valle; Kenneth B Margulies; Thomas P Cappola; Ankit A Desai; Lauren N Pedersen; Carmen Bergom; Nathan O Stitziel; Michael P Rettig; John F DiPersio; Stefan Hajny; Christina Christoffersen; Abhinav Diwan; Ali Javaheri

doi:10.1016/j.jacbts.2022.09.010

Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury

Zhen Guo, Carla Valenzuela Ripoll, Antonino Picataggi, David R Rawnsley, Mualla Ozcan, Julio A Chirinos, Ezhilarasi Chendamarai, Amanda Girardi, Terrence Riehl, Hosannah Evie, Ahmed Diab, Attila Kovacs, Krzysztof Hyrc, Xiucui Ma, Aarti Asnani, Swapnil V Shewale, Marielle Scherrer-Crosbie, Lauren Ashley Cowart, John S Parks, Lei ZhaoDavid Gordon, Francisco Ramirez-Valle, Kenneth B Margulies, Thomas P Cappola, Ankit A Desai, Lauren N Pedersen, Carmen Bergom, Nathan O Stitziel, Michael P Rettig, John F DiPersio, Stefan Hajny, Christina Christoffersen, Abhinav Diwan, Ali Javaheri^*

^*Corresponding author af dette arbejde

Afdeling for Klinisk Biokemi

16 Citationer (Scopus)

Abstract

Apolipoprotein M (ApoM) binds sphingosine-1-phosphate (S1P) and is inversely associated with mortality in human heart failure (HF). Here, we show that anthracyclines such as doxorubicin (Dox) reduce circulating ApoM in mice and humans, that ApoM is inversely associated with mortality in patients with anthracycline-induced heart failure, and ApoM heterozygosity in mice increases Dox-induced mortality. In the setting of Dox stress, our studies suggest ApoM can help sustain myocardial autophagic flux in a post-transcriptional manner, attenuate Dox cardiotoxicity, and prevent lysosomal injury.

Originalsprog	Engelsk
Tidsskrift	JACC. Basic to translational science
Vol/bind	8
Udgave nummer	3
Sider (fra-til)	340-355
Antal sider	16
ISSN	2452-302X
DOI	https://doi.org/10.1016/j.jacbts.2022.09.010
Status	Udgivet - mar. 2023

Adgang til dokumentet

10.1016/j.jacbts.2022.09.010

Andre filer og links

Link to publication in Scopus

Citationsformater

Guo, Z., Valenzuela Ripoll, C., Picataggi, A., Rawnsley, D. R., Ozcan, M., Chirinos, J. A., Chendamarai, E., Girardi, A., Riehl, T., Evie, H., Diab, A., Kovacs, A., Hyrc, K., Ma, X., Asnani, A., Shewale, S. V., Scherrer-Crosbie, M., Cowart, L. A., Parks, J. S., ... Javaheri, A. (2023). Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury. JACC. Basic to translational science, 8(3), 340-355. https://doi.org/10.1016/j.jacbts.2022.09.010

Guo, Z, Valenzuela Ripoll, C, Picataggi, A, Rawnsley, DR, Ozcan, M, Chirinos, JA, Chendamarai, E, Girardi, A, Riehl, T, Evie, H, Diab, A, Kovacs, A, Hyrc, K, Ma, X, Asnani, A, Shewale, SV, Scherrer-Crosbie, M, Cowart, LA, Parks, JS, Zhao, L, Gordon, D, Ramirez-Valle, F, Margulies, KB, Cappola, TP, Desai, AA, Pedersen, LN, Bergom, C, Stitziel, NO, Rettig, MP, DiPersio, JF, Hajny, S, Christoffersen, C, Diwan, A & Javaheri, A 2023, 'Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury', JACC. Basic to translational science, bind 8, nr. 3, s. 340-355. https://doi.org/10.1016/j.jacbts.2022.09.010

@article{dd1c128ccc294391bb2d28c9a09e5d9c,

title = "Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury",

abstract = "Apolipoprotein M (ApoM) binds sphingosine-1-phosphate (S1P) and is inversely associated with mortality in human heart failure (HF). Here, we show that anthracyclines such as doxorubicin (Dox) reduce circulating ApoM in mice and humans, that ApoM is inversely associated with mortality in patients with anthracycline-induced heart failure, and ApoM heterozygosity in mice increases Dox-induced mortality. In the setting of Dox stress, our studies suggest ApoM can help sustain myocardial autophagic flux in a post-transcriptional manner, attenuate Dox cardiotoxicity, and prevent lysosomal injury.",

author = "Zhen Guo and {Valenzuela Ripoll}, Carla and Antonino Picataggi and Rawnsley, {David R} and Mualla Ozcan and Chirinos, {Julio A} and Ezhilarasi Chendamarai and Amanda Girardi and Terrence Riehl and Hosannah Evie and Ahmed Diab and Attila Kovacs and Krzysztof Hyrc and Xiucui Ma and Aarti Asnani and Shewale, {Swapnil V} and Marielle Scherrer-Crosbie and Cowart, {Lauren Ashley} and Parks, {John S} and Lei Zhao and David Gordon and Francisco Ramirez-Valle and Margulies, {Kenneth B} and Cappola, {Thomas P} and Desai, {Ankit A} and Pedersen, {Lauren N} and Carmen Bergom and Stitziel, {Nathan O} and Rettig, {Michael P} and DiPersio, {John F} and Stefan Hajny and Christina Christoffersen and Abhinav Diwan and Ali Javaheri",

note = "{\textcopyright} 2023 The Authors.",

year = "2023",

month = mar,

doi = "10.1016/j.jacbts.2022.09.010",

language = "English",

volume = "8",

pages = "340--355",

journal = "JACC. Basic to translational science",

issn = "2452-302X",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury

AU - Guo, Zhen

AU - Valenzuela Ripoll, Carla

AU - Picataggi, Antonino

AU - Rawnsley, David R

AU - Ozcan, Mualla

AU - Chirinos, Julio A

AU - Chendamarai, Ezhilarasi

AU - Girardi, Amanda

AU - Riehl, Terrence

AU - Evie, Hosannah

AU - Diab, Ahmed

AU - Kovacs, Attila

AU - Hyrc, Krzysztof

AU - Ma, Xiucui

AU - Asnani, Aarti

AU - Shewale, Swapnil V

AU - Scherrer-Crosbie, Marielle

AU - Cowart, Lauren Ashley

AU - Parks, John S

AU - Zhao, Lei

AU - Gordon, David

AU - Ramirez-Valle, Francisco

AU - Margulies, Kenneth B

AU - Cappola, Thomas P

AU - Desai, Ankit A

AU - Pedersen, Lauren N

AU - Bergom, Carmen

AU - Stitziel, Nathan O

AU - Rettig, Michael P

AU - DiPersio, John F

AU - Hajny, Stefan

AU - Christoffersen, Christina

AU - Diwan, Abhinav

AU - Javaheri, Ali

PY - 2023/3

Y1 - 2023/3

N2 - Apolipoprotein M (ApoM) binds sphingosine-1-phosphate (S1P) and is inversely associated with mortality in human heart failure (HF). Here, we show that anthracyclines such as doxorubicin (Dox) reduce circulating ApoM in mice and humans, that ApoM is inversely associated with mortality in patients with anthracycline-induced heart failure, and ApoM heterozygosity in mice increases Dox-induced mortality. In the setting of Dox stress, our studies suggest ApoM can help sustain myocardial autophagic flux in a post-transcriptional manner, attenuate Dox cardiotoxicity, and prevent lysosomal injury.

AB - Apolipoprotein M (ApoM) binds sphingosine-1-phosphate (S1P) and is inversely associated with mortality in human heart failure (HF). Here, we show that anthracyclines such as doxorubicin (Dox) reduce circulating ApoM in mice and humans, that ApoM is inversely associated with mortality in patients with anthracycline-induced heart failure, and ApoM heterozygosity in mice increases Dox-induced mortality. In the setting of Dox stress, our studies suggest ApoM can help sustain myocardial autophagic flux in a post-transcriptional manner, attenuate Dox cardiotoxicity, and prevent lysosomal injury.

UR - http://www.scopus.com/inward/record.url?scp=85150029297&partnerID=8YFLogxK

U2 - 10.1016/j.jacbts.2022.09.010

DO - 10.1016/j.jacbts.2022.09.010

M3 - Journal article

C2 - 37034289

SN - 2452-302X

VL - 8

SP - 340

EP - 355

JO - JACC. Basic to translational science

JF - JACC. Basic to translational science

IS - 3

ER -

Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury

Abstract

Adgang til dokumentet

Andre filer og links

Fingeraftryk

Citationsformater