Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals

Tauseef A Khan; Tina Shah; David Prieto; Weili Zhang; Jackie Price; Gerald R Fowkes; Jackie Cooper; Philippa J Talmud; Steve E Humphries; Johan Sundstrom; Jaroslav A Hubacek; Shah Ebrahim; Debbie A Lawlor; Yoav Ben-Shlomo; Mohammad R Abdollahi; Arjen J C Slooter; Zoltan Szolnoki; Manjinder Sandhu; Nicholas Wareham; Ruth Frikke-Schmidt; Anne Tybjærg-Hansen; Gerda Fillenbaum; Bastiaan T Heijmans; Tomohiro Katsuya; Grazyna Gromadzka; Andrew Singleton; Luigi Ferrucci; John Hardy; Bradford Worrall; Stephen S Rich; Mar Matarin; John Whittaker; Tom R Gaunt; Peter Whincup; Richard Morris; John Deanfield; Ann Donald; George Davey Smith; Mika Kivimaki; Meena Kumari; Liam Smeeth; Kay-Tee Khaw; Michael Nalls; James Meschia; Kai Sun; Rutai Hui; Ian Day; Aroon D Hingorani; Juan P Casas

doi:10.1093/ije/dyt034

Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals

Tauseef A Khan, Tina Shah, David Prieto, Weili Zhang, Jackie Price, Gerald R Fowkes, Jackie Cooper, Philippa J Talmud, Steve E Humphries, Johan Sundstrom, Jaroslav A Hubacek, Shah Ebrahim, Debbie A Lawlor, Yoav Ben-Shlomo, Mohammad R Abdollahi, Arjen J C Slooter, Zoltan Szolnoki, Manjinder Sandhu, Nicholas Wareham, Ruth Frikke-SchmidtAnne Tybjærg-Hansen, Gerda Fillenbaum, Bastiaan T Heijmans, Tomohiro Katsuya, Grazyna Gromadzka, Andrew Singleton, Luigi Ferrucci, John Hardy, Bradford Worrall, Stephen S Rich, Mar Matarin, John Whittaker, Tom R Gaunt, Peter Whincup, Richard Morris, John Deanfield, Ann Donald, George Davey Smith, Mika Kivimaki, Meena Kumari, Liam Smeeth, Kay-Tee Khaw, Michael Nalls, James Meschia, Kai Sun, Rutai Hui, Ian Day, Aroon D Hingorani, Juan P Casas

Afdeling for Klinisk Biokemi

132 Citationer (Scopus)

Abstract

At the APOE gene, encoding apolipoprotein E, genotypes of the ε2/ε3/ε4 alleles associated with higher LDL-cholesterol (LDL-C) levels are also associated with higher coronary risk. However, the association of APOE genotype with other cardiovascular biomarkers and risk of ischaemic stroke is less clear. We evaluated the association of APOE genotype with risk of ischaemic stroke and assessed whether the observed effect was consistent with the effects of APOE genotype on LDL-C or other lipids and biomarkers of cardiovascular risk.

Originalsprog	Engelsk
Tidsskrift	International Journal of Epidemiology
Vol/bind	42
Udgave nummer	2
Sider (fra-til)	475-92
Antal sider	18
ISSN	0300-5771
DOI	https://doi.org/10.1093/ije/dyt034
Status	Udgivet - apr. 2013

Adgang til dokumentet

10.1093/ije/dyt034

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Citationsformater

Khan, T. A., Shah, T., Prieto, D., Zhang, W., Price, J., Fowkes, G. R., Cooper, J., Talmud, P. J., Humphries, S. E., Sundstrom, J., Hubacek, J. A., Ebrahim, S., Lawlor, D. A., Ben-Shlomo, Y., Abdollahi, M. R., Slooter, A. J. C., Szolnoki, Z., Sandhu, M., Wareham, N., ... Casas, J. P. (2013). Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals. International Journal of Epidemiology, 42(2), 475-92. https://doi.org/10.1093/ije/dyt034

Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals. / Khan, Tauseef A; Shah, Tina; Prieto, David et al.
I: International Journal of Epidemiology, Bind 42, Nr. 2, 04.2013, s. 475-92.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Khan, TA, Shah, T, Prieto, D, Zhang, W, Price, J, Fowkes, GR, Cooper, J, Talmud, PJ, Humphries, SE, Sundstrom, J, Hubacek, JA, Ebrahim, S, Lawlor, DA, Ben-Shlomo, Y, Abdollahi, MR, Slooter, AJC, Szolnoki, Z, Sandhu, M, Wareham, N, Frikke-Schmidt, R , Tybjærg-Hansen, A, Fillenbaum, G, Heijmans, BT, Katsuya, T, Gromadzka, G, Singleton, A, Ferrucci, L, Hardy, J, Worrall, B, Rich, SS, Matarin, M, Whittaker, J, Gaunt, TR, Whincup, P, Morris, R, Deanfield, J, Donald, A, Davey Smith, G, Kivimaki, M, Kumari, M, Smeeth, L, Khaw, K-T, Nalls, M, Meschia, J, Sun, K, Hui, R, Day, I, Hingorani, AD & Casas, JP 2013, 'Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: systematic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals', International Journal of Epidemiology, bind 42, nr. 2, s. 475-92. https://doi.org/10.1093/ije/dyt034

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abstract = "At the APOE gene, encoding apolipoprotein E, genotypes of the ε2/ε3/ε4 alleles associated with higher LDL-cholesterol (LDL-C) levels are also associated with higher coronary risk. However, the association of APOE genotype with other cardiovascular biomarkers and risk of ischaemic stroke is less clear. We evaluated the association of APOE genotype with risk of ischaemic stroke and assessed whether the observed effect was consistent with the effects of APOE genotype on LDL-C or other lipids and biomarkers of cardiovascular risk.",

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AU - Khan, Tauseef A

AU - Shah, Tina

AU - Prieto, David

AU - Zhang, Weili

AU - Price, Jackie

AU - Fowkes, Gerald R

AU - Cooper, Jackie

AU - Talmud, Philippa J

AU - Humphries, Steve E

AU - Sundstrom, Johan

AU - Hubacek, Jaroslav A

AU - Ebrahim, Shah

AU - Lawlor, Debbie A

AU - Ben-Shlomo, Yoav

AU - Abdollahi, Mohammad R

AU - Slooter, Arjen J C

AU - Szolnoki, Zoltan

AU - Sandhu, Manjinder

AU - Wareham, Nicholas

AU - Frikke-Schmidt, Ruth

AU - Tybjærg-Hansen, Anne

AU - Fillenbaum, Gerda

AU - Heijmans, Bastiaan T

AU - Katsuya, Tomohiro

AU - Gromadzka, Grazyna

AU - Singleton, Andrew

AU - Ferrucci, Luigi

AU - Hardy, John

AU - Worrall, Bradford

AU - Rich, Stephen S

AU - Matarin, Mar

AU - Whittaker, John

AU - Gaunt, Tom R

AU - Whincup, Peter

AU - Morris, Richard

AU - Deanfield, John

AU - Donald, Ann

AU - Davey Smith, George

AU - Kivimaki, Mika

AU - Kumari, Meena

AU - Smeeth, Liam

AU - Khaw, Kay-Tee

AU - Nalls, Michael

AU - Meschia, James

AU - Sun, Kai

AU - Hui, Rutai

AU - Day, Ian

AU - Hingorani, Aroon D

AU - Casas, Juan P

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AB - At the APOE gene, encoding apolipoprotein E, genotypes of the ε2/ε3/ε4 alleles associated with higher LDL-cholesterol (LDL-C) levels are also associated with higher coronary risk. However, the association of APOE genotype with other cardiovascular biomarkers and risk of ischaemic stroke is less clear. We evaluated the association of APOE genotype with risk of ischaemic stroke and assessed whether the observed effect was consistent with the effects of APOE genotype on LDL-C or other lipids and biomarkers of cardiovascular risk.

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