Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Apolipoprotein D and transthyretin are reduced in female adolescent offspring of women with type 1 diabetes: The EPICOM study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. International comparison of glycaemic control in people with type 1 diabetes: an update and extension

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Differences in insulin sensitivity in the partial remission phase of childhood type 1 diabetes; a longitudinal cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Association of type 1 diabetes and educational achievement in 16-20-year-olds: A Danish nationwide register study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Early Coronary Atherosclerosis in Women With Previous Preeclampsia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Pregnancy outcomes in women with type 1 diabetes using insulin degludec

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. School performance in Danish children exposed to maternal type 1 diabetes in utero: A nationwide retrospective cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

AIMS: Adolescent offspring exposed to maternal diabetes during intrauterine life show a less favourable metabolic profile than the background population. Here, we hypothesize that offspring of women with type 1 diabetes (T1D), possess sex-specific alterations in the serum profile of proteins involved in lipid, metabolic and transport processes and that these alterations are associated with lipid profile and indices of insulin sensitivity and secretion.

METHODS: A prospective nationwide follow-up study (EPICOM) in a Danish population. Blood samples were assessed from offspring of women with T1D (index offspring, n = 267, 13-20 years), and matched control offspring (n = 290). Serum proteins were analysed using a 25-plex cardio-metabolic targeted proteomics assay, which includes 12 apolipoproteins and 13 transport and inflammatory proteins.

RESULTS: Apolipoprotein D (ApoD) and transthyretin (TTR) were reduced in index females as compared to female controls (-8.1%, p < 0.001 and -6.1%, p = 0.006 respectively), but not in index males (2.2%, p = 0.476 and -2.4%, p = 0.731 respectively). Sex-dependent inverse associations between exposure to maternal T1D in utero and ApoD and TTR were significant after adjusting for age, BMI-SDS and Tanner stage (OR = 0.252 [95% CI 0.085, 0.745], p = 0.013 and OR = 0.149 [95% CI 0.040, 0.553], p = 0.004). ApoD correlated to indices of insulin sensitivity and secretion in a similar sex-specific pattern in crude and adjusted analyses.

CONCLUSIONS: Low ApoD may be regarded as an early risk marker of metabolic syndrome. A possible link between ApoD and cardiovascular disease needs further investigation.

OriginalsprogEngelsk
Artikelnummere14776
TidsskriftDiabetic medicine : a journal of the British Diabetic Association
Vol/bind39
Udgave nummer7
Sider (fra-til)e14776
ISSN0742-3071
DOI
StatusUdgivet - jul. 2022

Bibliografisk note

© 2021 Diabetes UK.

ID: 70143049