Apixaban versus enoxaparin for thromboprophylaxis in medically ill patients

Samuel Z Goldhaber; Alain Leizorovicz; Ajay K Kakkar; Sylvia K Haas; Geno Merli; Robert M Knabb; Jeffrey I Weitz; ADOPT Trial Investigators (Christian Tobias Torp-Pedersen, members)

doi:10.1056/NEJMoa1110899

Apixaban versus enoxaparin for thromboprophylaxis in medically ill patients

Samuel Z Goldhaber
, Alain Leizorovicz
, Ajay K Kakkar
, Sylvia K Haas
, Geno Merli
, Robert M Knabb
, Jeffrey I Weitz
, ADOPT Trial Investigators (Christian Tobias Torp-Pedersen, members)

535 Citationer (Scopus)

Abstract

The efficacy and safety of prolonging prophylaxis for venous thromboembolism in medically ill patients beyond hospital discharge remain uncertain. We hypothesized that extended prophylaxis with apixaban would be safe and more effective than short-term prophylaxis with enoxaparin.

Originalsprog	Engelsk
Tidsskrift	New England Journal of Medicine
Vol/bind	365
Udgave nummer	23
Sider (fra-til)	2167-77
Antal sider	11
ISSN	0028-4793
DOI	https://doi.org/10.1056/NEJMoa1110899
Status	Udgivet - 8 dec. 2011

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10.1056/NEJMoa1110899

Citationsformater

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title = "Apixaban versus enoxaparin for thromboprophylaxis in medically ill patients",

abstract = "The efficacy and safety of prolonging prophylaxis for venous thromboembolism in medically ill patients beyond hospital discharge remain uncertain. We hypothesized that extended prophylaxis with apixaban would be safe and more effective than short-term prophylaxis with enoxaparin.",

keywords = "Acute Disease, Adult, Aged, Aged, 80 and over, Anticoagulants, Double-Blind Method, Drug Administration Schedule, Enoxaparin, Female, Heart Failure, Hemorrhage, Hospitalization, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Pulmonary Embolism, Pyrazoles, Pyridones, Respiratory Insufficiency, Risk Factors, Treatment Outcome, Venous Thromboembolism",

author = "Goldhaber, \{Samuel Z\} and Alain Leizorovicz and Kakkar, \{Ajay K\} and Haas, \{Sylvia K\} and Geno Merli and Knabb, \{Robert M\} and Weitz, \{Jeffrey I\} and \{ADOPT Trial Investigators (Christian Tobias Torp-Pedersen, members)\} and Torp-Pedersen, \{Christian Tobias\}",

year = "2011",

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doi = "10.1056/NEJMoa1110899",

language = "English",

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TY - JOUR

T1 - Apixaban versus enoxaparin for thromboprophylaxis in medically ill patients

AU - Goldhaber, Samuel Z

AU - Leizorovicz, Alain

AU - Kakkar, Ajay K

AU - Haas, Sylvia K

AU - Merli, Geno

AU - Knabb, Robert M

AU - Weitz, Jeffrey I

AU - ADOPT Trial Investigators (Christian Tobias Torp-Pedersen, members)

A2 - Torp-Pedersen, Christian Tobias

PY - 2011/12/8

Y1 - 2011/12/8

N2 - The efficacy and safety of prolonging prophylaxis for venous thromboembolism in medically ill patients beyond hospital discharge remain uncertain. We hypothesized that extended prophylaxis with apixaban would be safe and more effective than short-term prophylaxis with enoxaparin.

AB - The efficacy and safety of prolonging prophylaxis for venous thromboembolism in medically ill patients beyond hospital discharge remain uncertain. We hypothesized that extended prophylaxis with apixaban would be safe and more effective than short-term prophylaxis with enoxaparin.

KW - Acute Disease

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Anticoagulants

KW - Double-Blind Method

KW - Drug Administration Schedule

KW - Enoxaparin

KW - Female

KW - Heart Failure

KW - Hemorrhage

KW - Hospitalization

KW - Humans

KW - Kaplan-Meier Estimate

KW - Male

KW - Middle Aged

KW - Pulmonary Embolism

KW - Pyrazoles

KW - Pyridones

KW - Respiratory Insufficiency

KW - Risk Factors

KW - Treatment Outcome

KW - Venous Thromboembolism

U2 - 10.1056/NEJMoa1110899

DO - 10.1056/NEJMoa1110899

M3 - Journal article

C2 - 22077144

SN - 0028-4793

VL - 365

SP - 2167

EP - 2177

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 23

ER -

Apixaban versus enoxaparin for thromboprophylaxis in medically ill patients

Abstract

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