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Apixaban in patients at risk of stroke undergoing atrial fibrillation ablation

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  • Paulus Kirchhof
  • Karl Georg Haeusler
  • Benjamin Blank
  • Joseph De Bono
  • David Callans
  • Arif Elvan
  • Thomas Fetsch
  • Isabelle C Van Gelder
  • Philip Gentlesk
  • Massimo Grimaldi
  • Jim Hansen
  • Gerhard Hindricks
  • Hussein R Al-Khalidi
  • Tyler Massaro
  • Lluis Mont
  • Jens Cosedis Nielsen
  • Georg Nölker
  • Jonathan P Piccini
  • Tom De Potter
  • Daniel Scherr
  • Ulrich Schotten
  • Sakis Themistoclakis
  • Derick Todd
  • Johan Vijgen
  • Luigi Di Biase
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Aims: It is recommended to perform atrial fibrillation ablation with continuous anticoagulation. Continuous apixaban has not been tested.

Methods and results: We compared continuous apixaban (5 mg b.i.d.) to vitamin K antagonists (VKA, international normalized ratio 2-3) in atrial fibrillation patients at risk of stroke a prospective, open, multi-centre study with blinded outcome assessment. Primary outcome was a composite of death, stroke, or bleeding (Bleeding Academic Research Consortium 2-5). A high-resolution brain magnetic resonance imaging (MRI) sub-study quantified acute brain lesions. Cognitive function was assessed by Montreal Cognitive Assessment (MoCA) at baseline and at end of follow-up. Overall, 674 patients (median age 64 years, 33% female, 42% non-paroxysmal atrial fibrillation, 49 sites) were randomized; 633 received study drug and underwent ablation; 335 undertook MRI (25 sites, 323 analysable scans). The primary outcome was observed in 22/318 patients randomized to apixaban, and in 23/315 randomized to VKA {difference -0.38% [90% confidence interval (CI) -4.0%, 3.3%], non-inferiority P = 0.0002 at the pre-specified absolute margin of 0.075}, including 2 (0.3%) deaths, 2 (0.3%) strokes, and 24 (3.8%) ISTH major bleeds. Acute small brain lesions were found in a similar number of patients in each arm [apixaban 44/162 (27.2%); VKA 40/161 (24.8%); P = 0.64]. Cognitive function increased at the end of follow-up (median 1 MoCA unit; P = 0.005) without differences between study groups.

Conclusions: Continuous apixaban is safe and effective in patients undergoing atrial fibrillation ablation at risk of stroke with respect to bleeding, stroke, and cognitive function. Further research is needed to reduce ablation-related acute brain lesions.

OriginalsprogEngelsk
TidsskriftEuropean Heart Journal
Vol/bind39
Udgave nummer32
Sider (fra-til)2942-2955
Antal sider14
ISSN0195-668X
DOI
StatusUdgivet - 21 aug. 2018

ID: 56234046