TY - JOUR
T1 - Aortic root distensibility and cross sectional areas in stented and subcoronary stentless bioprostheses in pigs
AU - Funder, Jonas Amstrup
AU - Ringgaard, Steffen
AU - Frost, Markus Winther
AU - Wierup, Per
AU - Klaaborg, Kaj Erik
AU - Hjortdal, Vibeke
AU - Nygaard, Hans
AU - Hasenkam, John Michael
PY - 2010
Y1 - 2010
N2 - A flexible aortic root is essential for natural leaflet stress distribution. It is suggested that stentless bioprosthetic valves retain the flexibility of native valves. We investigated aortic root distensibility and cross-sectional area (CSA) in stentless (Solo(R), n=4; Toronto SPV(R), n=7), stented (Mitroflow(R), n=8) and in native valves (n=8) in pigs. Magnetic resonance imaging was performed to assess aortic root areas. At the annular level the Solo(R) valve had a larger CSA (2.83+/-0.26 cm(2)) than both the Mitroflow(R)(2.24+/-0.23 cm(2)) and Toronto SPV(R) (1.87+/-0.59 cm(2)) ) (P=0.003; P=0.01). At the sino-tubular junction the Mitroflow(R) valve had a significantly larger CSA (2.96+/-0.80 cm(2)) than the Toronto SPV(R) (2.05+/-0.47 cm(2)); P=0.02). At the annular level the percentage change in area between end-diastole and end-systole was lower for the Mitroflow(R) than for all the other valves (P=0.006). No difference was found between native and stentless valves. In conclusion, the Solo(R) valve had a larger CSA at the annulus than both the Mitroflow(R) and the Toronto SPV(R). However, the stentless valves had a smaller CSA at the sino-tubular junction than the Mitroflow(R). We, furthermore, found that implantation of stentless heart valves preserves aortic root distensibility at the annular level in pigs. Keywords: Aortic valve replacement; Heart valve stentless; Heart valve bioprostheses; Magnetic resonance imaging.
AB - A flexible aortic root is essential for natural leaflet stress distribution. It is suggested that stentless bioprosthetic valves retain the flexibility of native valves. We investigated aortic root distensibility and cross-sectional area (CSA) in stentless (Solo(R), n=4; Toronto SPV(R), n=7), stented (Mitroflow(R), n=8) and in native valves (n=8) in pigs. Magnetic resonance imaging was performed to assess aortic root areas. At the annular level the Solo(R) valve had a larger CSA (2.83+/-0.26 cm(2)) than both the Mitroflow(R)(2.24+/-0.23 cm(2)) and Toronto SPV(R) (1.87+/-0.59 cm(2)) ) (P=0.003; P=0.01). At the sino-tubular junction the Mitroflow(R) valve had a significantly larger CSA (2.96+/-0.80 cm(2)) than the Toronto SPV(R) (2.05+/-0.47 cm(2)); P=0.02). At the annular level the percentage change in area between end-diastole and end-systole was lower for the Mitroflow(R) than for all the other valves (P=0.006). No difference was found between native and stentless valves. In conclusion, the Solo(R) valve had a larger CSA at the annulus than both the Mitroflow(R) and the Toronto SPV(R). However, the stentless valves had a smaller CSA at the sino-tubular junction than the Mitroflow(R). We, furthermore, found that implantation of stentless heart valves preserves aortic root distensibility at the annular level in pigs. Keywords: Aortic valve replacement; Heart valve stentless; Heart valve bioprostheses; Magnetic resonance imaging.
U2 - 10.1510/icvts.2009.230771
DO - 10.1510/icvts.2009.230771
M3 - Journal article
C2 - 20357011
SN - 1569-9293
VL - 10
SP - 976
EP - 980
JO - Interactive Cardiovascular and Thoracic Surgery
JF - Interactive Cardiovascular and Thoracic Surgery
IS - 6
ER -