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Antithrombotic Therapy and Major Adverse Limb Events in Patients With Chronic Lower Extremity Arterial Disease: Systematic Review and Meta-analysis from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy in Collaboration with the European Society of Cardiology Working Group on Aorta & Peripheral Vascular Diseases

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  • Gianluigi Savarese
  • Martin F Reiner
  • Alicia Uijl
  • Domenico D Amario
  • Stefan Agewall
  • Dan Atar
  • Iris Baumgartner
  • Claudio Borghi
  • Marco De Carlo
  • Heinz Drexel
  • Juan Carlos Kaski
  • Keld P Kjeldsen
  • Nils Kucher
  • Lars H Lund
  • Alexander Niessner
  • Anne Grete Semb
  • Thomas A Schmidt
  • Patrick Sulzgruber
  • Juan Tamargo
  • Cristiana Vitale
  • Sven Wassmann
  • Victor Aboyans
  • Basil S Lewis
Vis graf over relationer

INTRODUCTION: The role and selection of antithrombotic therapy to improve limb outcomes in chronic lower extremity artery disease (LEAD) is still debated. We conducted a meta-analysis to examine the efficacy and safety of anti-thrombotic and more intense antithrombotic therapy on limb outcomes and limb salvage in patients with chronic LEAD.

METHODS: Study inclusion criteria were: enrollment of patients with LEAD, randomized allocation to more vs. less intense antithrombotic therapy [more vs. less intense single antiplatelet therapy (SAPT); dual antiplatelet therapy (DAPT) vs. SAPT; dual antithrombotic therapy vs. SAPT or oral anticoagulant]; enrolment of ≥ 200 patients; reporting of at least one of following outcomes: limb amputation or revascularization. Seven randomized studies enrolling 30'447 patients were included.

RESULTS: Over a median follow-up of 24 months, more vs. less intense antithrombotic therapy or placebo significantly reduced the risk of limb revascularization (relative risk [RR]: 0.89; 95% confidence interval [CI]: 0.83 - 0.94) and limb amputation (RR: 0.63, 95% confidence interval [CI]: 0.46-0.86), as well as stroke (RR: 0.82, 95% CI: 0.70-0.97). There was no statistically significant effect on the risk of myocardial infarction (RR: 0.98, 95% CI: 0.87-1.11), all-cause (RR: 0.93, 95% CI: 0.86-1.01) and cardiovascular death (RR: 0.97, 95% CI: 0.86-1.08). Risk of major bleeding increased (RR: 1.23, 95% CI: 1.04-1.44).

CONCLUSION: In patients with LEAD, more intense antithrombotic therapy reduces risk of limb amputation and revascularization as well as stroke, with an increase in the risk of bleeding events.

TidsskriftEuropean heart journal. Cardiovascular pharmacotherapy
StatusUdgivet - 2019

Bibliografisk note

© Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2019. For permissions, please email:

ID: 57737139