Antipsychotics and associated risk of out-of-hospital cardiac arrest

Peter Weeke; Aksel Jensen; Fredrik Folke; Gunnar Hilmar Gislason; Jonas Bjerring Olesen; Emil L Fosbøl; Mads Wissenberg; Freddy K Lippert; Erika Frischknecht Christensen; Søren Loumann Nielsen; Ellen Holm; Jørgen K Kanters; Henrik Enghusen Poulsen; Lars Køber; Christian Torp-Pedersen

doi:10.1038/clpt.2014.139

Antipsychotics and associated risk of out-of-hospital cardiac arrest

Peter Weeke, Aksel Jensen, Fredrik Folke, Gunnar Hilmar Gislason, Jonas Bjerring Olesen, Emil L Fosbøl, Mads Wissenberg, Freddy K Lippert, Erika Frischknecht Christensen, Søren Loumann Nielsen, Ellen Holm, Jørgen K Kanters, Henrik Enghusen Poulsen, Lars Køber, Christian Torp-Pedersen

31 Citationer (Scopus)

Abstract

Antipsychotic drugs have been associated with sudden cardiac death, but differences in the risk of out-of-hospital cardiac arrest (OHCA) associated with different antipsychotic drug classes are not clear. We identified all OHCA in Denmark (2001-2010). Risk of OHCA associated with antipsychotic drug use was evaluated by conditional logistic regression analysis in case-time-control models. In total, 2,205 (7.6%) of 28,947 OHCA patients received treatment with an antipsychotic drug at the time of event. Overall treatment with any antipsychotic was associated with OHCA (odds ratio [OR]= 1.53, 95% confidence interval [CI]:1.23-1.89) as was use with typical antipsychotics (OR= 1.66, CI: 1.27-2.17). By contrast, overall atypical antipsychotics drug use was not (OR= 1.29, CI: 0.90-1.85). Two individual typical antipsychotic drugs were associated with OHCA, haloperidol (OR= 2.43, CI: 1.20-4.93) and levomepromazine (OR= 2.05, CI: 1.18-3.56) as was one atypical antipsychotic, quetiapine (OR= 3.64, CI: 1.59-8.30).Clinical Pharmacology & Therapeutics (2014); Accepted article preview online 24 June 2014; doi:10.1038/clpt.2014.139.

Originalsprog	Engelsk
Tidsskrift	Clinical Pharmacology and Therapeutics
Vol/bind	96
Udgave nummer	4
Sider (fra-til)	490-497
ISSN	0009-9236
DOI	https://doi.org/10.1038/clpt.2014.139
Status	Udgivet - 2014

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10.1038/clpt.2014.139

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Weeke, P., Jensen, A., Folke, F., Gislason, G. H., Olesen, J. B., Fosbøl, E. L., Wissenberg, M., Lippert, F. K., Christensen, E. F., Nielsen, S. L., Holm, E., Kanters, J. K., Poulsen, H. E., Køber, L., & Torp-Pedersen, C. (2014). Antipsychotics and associated risk of out-of-hospital cardiac arrest. Clinical Pharmacology and Therapeutics, 96(4), 490-497. https://doi.org/10.1038/clpt.2014.139

Weeke, P, Jensen, A, Folke, F , Gislason, GH , Olesen, JB , Fosbøl, EL, Wissenberg, M, Lippert, FK, Christensen, EF, Nielsen, SL, Holm, E, Kanters, JK, Poulsen, HE , Køber, L & Torp-Pedersen, C 2014, 'Antipsychotics and associated risk of out-of-hospital cardiac arrest', Clinical Pharmacology and Therapeutics, bind 96, nr. 4, s. 490-497. https://doi.org/10.1038/clpt.2014.139

@article{d636e9255f7a4fdeb2d92b40159e2a12,

title = "Antipsychotics and associated risk of out-of-hospital cardiac arrest",

abstract = "Antipsychotic drugs have been associated with sudden cardiac death, but differences in the risk of out-of-hospital cardiac arrest (OHCA) associated with different antipsychotic drug classes are not clear. We identified all OHCA in Denmark (2001-2010). Risk of OHCA associated with antipsychotic drug use was evaluated by conditional logistic regression analysis in case-time-control models. In total, 2,205 (7.6%) of 28,947 OHCA patients received treatment with an antipsychotic drug at the time of event. Overall treatment with any antipsychotic was associated with OHCA (odds ratio [OR]= 1.53, 95% confidence interval [CI]:1.23-1.89) as was use with typical antipsychotics (OR= 1.66, CI: 1.27-2.17). By contrast, overall atypical antipsychotics drug use was not (OR= 1.29, CI: 0.90-1.85). Two individual typical antipsychotic drugs were associated with OHCA, haloperidol (OR= 2.43, CI: 1.20-4.93) and levomepromazine (OR= 2.05, CI: 1.18-3.56) as was one atypical antipsychotic, quetiapine (OR= 3.64, CI: 1.59-8.30).Clinical Pharmacology & Therapeutics (2014); Accepted article preview online 24 June 2014; doi:10.1038/clpt.2014.139.",

author = "Peter Weeke and Aksel Jensen and Fredrik Folke and Gislason, {Gunnar Hilmar} and Olesen, {Jonas Bjerring} and Fosb{\o}l, {Emil L} and Mads Wissenberg and Lippert, {Freddy K} and Christensen, {Erika Frischknecht} and Nielsen, {S{\o}ren Loumann} and Ellen Holm and Kanters, {J{\o}rgen K} and Poulsen, {Henrik Enghusen} and Lars K{\o}ber and Christian Torp-Pedersen",

year = "2014",

doi = "10.1038/clpt.2014.139",

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AU - Weeke, Peter

AU - Jensen, Aksel

AU - Folke, Fredrik

AU - Gislason, Gunnar Hilmar

AU - Olesen, Jonas Bjerring

AU - Fosbøl, Emil L

AU - Wissenberg, Mads

AU - Lippert, Freddy K

AU - Christensen, Erika Frischknecht

AU - Nielsen, Søren Loumann

AU - Holm, Ellen

AU - Kanters, Jørgen K

AU - Poulsen, Henrik Enghusen

AU - Køber, Lars

AU - Torp-Pedersen, Christian

PY - 2014

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N2 - Antipsychotic drugs have been associated with sudden cardiac death, but differences in the risk of out-of-hospital cardiac arrest (OHCA) associated with different antipsychotic drug classes are not clear. We identified all OHCA in Denmark (2001-2010). Risk of OHCA associated with antipsychotic drug use was evaluated by conditional logistic regression analysis in case-time-control models. In total, 2,205 (7.6%) of 28,947 OHCA patients received treatment with an antipsychotic drug at the time of event. Overall treatment with any antipsychotic was associated with OHCA (odds ratio [OR]= 1.53, 95% confidence interval [CI]:1.23-1.89) as was use with typical antipsychotics (OR= 1.66, CI: 1.27-2.17). By contrast, overall atypical antipsychotics drug use was not (OR= 1.29, CI: 0.90-1.85). Two individual typical antipsychotic drugs were associated with OHCA, haloperidol (OR= 2.43, CI: 1.20-4.93) and levomepromazine (OR= 2.05, CI: 1.18-3.56) as was one atypical antipsychotic, quetiapine (OR= 3.64, CI: 1.59-8.30).Clinical Pharmacology & Therapeutics (2014); Accepted article preview online 24 June 2014; doi:10.1038/clpt.2014.139.

AB - Antipsychotic drugs have been associated with sudden cardiac death, but differences in the risk of out-of-hospital cardiac arrest (OHCA) associated with different antipsychotic drug classes are not clear. We identified all OHCA in Denmark (2001-2010). Risk of OHCA associated with antipsychotic drug use was evaluated by conditional logistic regression analysis in case-time-control models. In total, 2,205 (7.6%) of 28,947 OHCA patients received treatment with an antipsychotic drug at the time of event. Overall treatment with any antipsychotic was associated with OHCA (odds ratio [OR]= 1.53, 95% confidence interval [CI]:1.23-1.89) as was use with typical antipsychotics (OR= 1.66, CI: 1.27-2.17). By contrast, overall atypical antipsychotics drug use was not (OR= 1.29, CI: 0.90-1.85). Two individual typical antipsychotic drugs were associated with OHCA, haloperidol (OR= 2.43, CI: 1.20-4.93) and levomepromazine (OR= 2.05, CI: 1.18-3.56) as was one atypical antipsychotic, quetiapine (OR= 3.64, CI: 1.59-8.30).Clinical Pharmacology & Therapeutics (2014); Accepted article preview online 24 June 2014; doi:10.1038/clpt.2014.139.

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DO - 10.1038/clpt.2014.139

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ER -

Antipsychotics and associated risk of out-of-hospital cardiac arrest

Abstract

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