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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Anti-Pseudomonas aeruginosa IgY antibodies promote bacterial opsonization and augment the phagocytic activity of polymorphonuclear neutrophils

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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Moderation of polymorphonuclear neutrophils (PMNs) as part of a critical defense against invading pathogens may offer a promising therapeutic approach to supplement the antibiotic eradication of Pseudomonas aeruginosa infection in non-chronically infected cystic fibrosis (CF) patients. We have observed that egg yolk antibodies (IgY) harvested from White leghorn chickens that target P. aeruginosa opsonize the pathogen and enhance the PMN-mediated respiratory burst and subsequent bacterial killing in vitro. The effects on PMN phagocytic activity were observed in different Pseudomonas aeruginosa strains, including clinical isolates from non-chronically infected CF patients. Thus, oral prophylaxis with anti-Pseudomonas aeruginosa IgY may boost the innate immunity against Pseudomonas aeruginosa in the CF setting by facilitating a rapid and prompt bacterial clearance by PMNs.

OriginalsprogEngelsk
TidsskriftHuman vaccines & immunotherapeutics
Vol/bind12
Udgave nummer7
Sider (fra-til)1690-9
Antal sider10
ISSN2164-5515
DOI
StatusUdgivet - 2 jul. 2016

ID: 49782146