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Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Antioxidant biomarkers and cardio-metabolic risk markers in an Aboriginal community in remote Australia: a cross-sectional study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  4. Antioxidants, vitamins and cardiometabolic risk markers in a very remote aboriginal population in Australia

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  • Lenette Knudsen
  • Jasmine G Lyons
  • Kerin O'Dea
  • Dirk L Christensen
  • Julie K Brimblecombe
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OBJECTIVE: High-quality diets, characterised by nutrient-rich foods, are one of the foundations for health and well-being. Indicators of diet quality, antioxidants, are associated with protection against cardiometabolic diseases. The current study explores relationships between plasma antioxidants and cardiometabolic risk among Aboriginal people in Australia.

DESIGN: As part of a community-driven health promotion programme, we conducted a cross-sectional study including a health-behaviour questionnaire, plasma antioxidants and cardiometabolic risk markers (anthropometric, blood pressure measurements, fasting glucose, glycated Hb (HbA1c), lipids, C-reactive protein and albumin-creatinine-ratio) continuous and categorised into population-specific cut-offs. Antioxidants (β-carotene, β-cryptoxanthin, lycopene, lutein-zeaxanthin, retinol and α-tocopherol measured using HPLC) were applied to a principal component analysis, which aggregated these into a single component. Linear regression models were applied to investigate associations between the antioxidant component and cardiometabolic risk markers.

SETTING: Community in a remote area in Northern Territory, Australia.

PARTICIPANTS: A total of 324 Aboriginal people, mean age 35·5 (range 15-75) years.

RESULTS: Antioxidant component levels were higher among individuals with higher self-reported vegetable intake (P < 0·01), higher among individuals with higher self-reported fruit intake (P = 0·05) and lower among current smokers (P = 0·06). Linear regression revealed an inverse association between the antioxidant component and C-reactive protein (β = -0·01, P < 0·01) after adjusting for confounders.

CONCLUSION: Higher plasma antioxidant levels, indicators of diet quality, were associated with lower levels of high-sensitivity C-reactive protein in this Aboriginal population in remote Australia. This association suggests plasma antioxidants may be protective against inflammation; however, longitudinal studies are needed to examine this potentially protective relationship.

OriginalsprogEngelsk
TidsskriftPublic Health Nutrition
Sider (fra-til)1-12
Antal sider12
ISSN1368-9800
DOI
StatusE-pub ahead of print - 2 dec. 2020

ID: 61374351